Application of the Extracts of <i>Uncaria tomentosa</i> in Endodontics and Oral Medicine: Scoping Review
Background: The main purpose of endodontic treatment is to eliminate the bacteria that are responsible for the contamination and infection of the internal surfaces in order to resolve any pulp or periapical pathology. In fact, some bacteria, such as <i>Enterococcus faecalis</i>, can esca...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/17/5024 |
| _version_ | 1797494764277334016 |
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| author | Mario Dioguardi Francesca Spirito Diego Sovereto Andrea Ballini Mario Alovisi Lorenzo Lo Muzio |
| author_facet | Mario Dioguardi Francesca Spirito Diego Sovereto Andrea Ballini Mario Alovisi Lorenzo Lo Muzio |
| author_sort | Mario Dioguardi |
| collection | DOAJ |
| description | Background: The main purpose of endodontic treatment is to eliminate the bacteria that are responsible for the contamination and infection of the internal surfaces in order to resolve any pulp or periapical pathology. In fact, some bacteria, such as <i>Enterococcus faecalis</i>, can escape the action of root canal irrigants by aggregating into a biofilm and penetrating deeply into the dentinal tubules. <i>Uncaria tomentosa</i> is a plant belonging to the Rubiaceae family and also commonly known as cat’s claw due to the shape and position of the spines; it is a traditional Peruvian medicinal plant of Amazonian origin. Applications in the dental field have been described both in the prevention and treatment of stomatitis and as an antibacterial and anti-inflammatory agent; it has also been investigated as an additive in irrigants and specifically as gels in endodontic cements. The aim of this scoping review is to summarize all the scientific evidence on the possible applications of <i>Uncaria</i> tomentosa extracts in endodontics and, more generally, in oral medicine, in order to understand whether the active ingredients extracted from <i>Uncaria tomentosa</i> can bring a real advantage in endodontics, in the reduction of endodontic failures and in the onset of recurrent endodontic lesions. Methods: The scoping review was carried out strictly following the PRISMA-ScR checklist; the search was carried out on five databases (PubMed, Scopus, Science Direct, EBSCO and Web of Science) and a register (Cochrane library). Results: The research produced a number of bibliographic sources totaling 2104. With the removal of duplicates, 670 were obtained; potentially eligible articles amounted to 23, of which only seven in vitro studies (four microbiological studies), five clinical studies (three randomized trials) and a case report were included. Conclusions: From the data in the literature, it can be stated that the active ingredients present in <i>Uncaria tomentosa</i> could represent an interesting product to be used in the endodontic field, both in endocanalary cements and as a gel. |
| first_indexed | 2024-03-10T01:39:04Z |
| format | Article |
| id | doaj.art-1174c497b57741348baa5771eacdd311 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:39:04Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-1174c497b57741348baa5771eacdd3112023-11-23T13:26:20ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011117502410.3390/jcm11175024Application of the Extracts of <i>Uncaria tomentosa</i> in Endodontics and Oral Medicine: Scoping ReviewMario Dioguardi0Francesca Spirito1Diego Sovereto2Andrea Ballini3Mario Alovisi4Lorenzo Lo Muzio5Department of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, 80138 Naples, ItalyDepartment of Surgical Sciences, Dental School, University of Turin, 10127 Turin, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, Via Rovelli 50, 71122 Foggia, ItalyBackground: The main purpose of endodontic treatment is to eliminate the bacteria that are responsible for the contamination and infection of the internal surfaces in order to resolve any pulp or periapical pathology. In fact, some bacteria, such as <i>Enterococcus faecalis</i>, can escape the action of root canal irrigants by aggregating into a biofilm and penetrating deeply into the dentinal tubules. <i>Uncaria tomentosa</i> is a plant belonging to the Rubiaceae family and also commonly known as cat’s claw due to the shape and position of the spines; it is a traditional Peruvian medicinal plant of Amazonian origin. Applications in the dental field have been described both in the prevention and treatment of stomatitis and as an antibacterial and anti-inflammatory agent; it has also been investigated as an additive in irrigants and specifically as gels in endodontic cements. The aim of this scoping review is to summarize all the scientific evidence on the possible applications of <i>Uncaria</i> tomentosa extracts in endodontics and, more generally, in oral medicine, in order to understand whether the active ingredients extracted from <i>Uncaria tomentosa</i> can bring a real advantage in endodontics, in the reduction of endodontic failures and in the onset of recurrent endodontic lesions. Methods: The scoping review was carried out strictly following the PRISMA-ScR checklist; the search was carried out on five databases (PubMed, Scopus, Science Direct, EBSCO and Web of Science) and a register (Cochrane library). Results: The research produced a number of bibliographic sources totaling 2104. With the removal of duplicates, 670 were obtained; potentially eligible articles amounted to 23, of which only seven in vitro studies (four microbiological studies), five clinical studies (three randomized trials) and a case report were included. Conclusions: From the data in the literature, it can be stated that the active ingredients present in <i>Uncaria tomentosa</i> could represent an interesting product to be used in the endodontic field, both in endocanalary cements and as a gel.https://www.mdpi.com/2077-0383/11/17/5024<i>Uncaria tomentosa</i>endodonticsoral medicinestomatitiscat’s claw<i>Enterococcus faecalis</i> |
| spellingShingle | Mario Dioguardi Francesca Spirito Diego Sovereto Andrea Ballini Mario Alovisi Lorenzo Lo Muzio Application of the Extracts of <i>Uncaria tomentosa</i> in Endodontics and Oral Medicine: Scoping Review Journal of Clinical Medicine <i>Uncaria tomentosa</i> endodontics oral medicine stomatitis cat’s claw <i>Enterococcus faecalis</i> |
| title | Application of the Extracts of <i>Uncaria tomentosa</i> in Endodontics and Oral Medicine: Scoping Review |
| title_full | Application of the Extracts of <i>Uncaria tomentosa</i> in Endodontics and Oral Medicine: Scoping Review |
| title_fullStr | Application of the Extracts of <i>Uncaria tomentosa</i> in Endodontics and Oral Medicine: Scoping Review |
| title_full_unstemmed | Application of the Extracts of <i>Uncaria tomentosa</i> in Endodontics and Oral Medicine: Scoping Review |
| title_short | Application of the Extracts of <i>Uncaria tomentosa</i> in Endodontics and Oral Medicine: Scoping Review |
| title_sort | application of the extracts of i uncaria tomentosa i in endodontics and oral medicine scoping review |
| topic | <i>Uncaria tomentosa</i> endodontics oral medicine stomatitis cat’s claw <i>Enterococcus faecalis</i> |
| url | https://www.mdpi.com/2077-0383/11/17/5024 |
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