Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells
The ability of cancer cells to detach from the primary site and metastasize is the main cause of cancer- related death among all cancer types. Epithelial-to-mesenchymal transition (EMT) is the first event of the metastatic cascade, resulting in the loss of cell–cell adhesion and the acquisition of m...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/11/1604 |
| _version_ | 1797459954343346176 |
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| author | Huda I. Atiya Grace Gorecki Geyon L. Garcia Leonard G. Frisbie Roja Baruwal Lan Coffman |
| author_facet | Huda I. Atiya Grace Gorecki Geyon L. Garcia Leonard G. Frisbie Roja Baruwal Lan Coffman |
| author_sort | Huda I. Atiya |
| collection | DOAJ |
| description | The ability of cancer cells to detach from the primary site and metastasize is the main cause of cancer- related death among all cancer types. Epithelial-to-mesenchymal transition (EMT) is the first event of the metastatic cascade, resulting in the loss of cell–cell adhesion and the acquisition of motile and stem-like phenotypes. A critical modulator of EMT in cancer cells is the stromal tumor microenvironment (TME), which can promote the acquisition of a mesenchymal phenotype through direct interaction with cancer cells or changes to the broader microenvironment. In this review, we will explore the role of stromal cells in modulating cancer cell EMT, with particular emphasis on the function of mesenchymal stromal/stem cells (MSCs) through the activation of EMT-inducing pathways, extra cellular matrix (ECM) remodeling, immune cell alteration, and metabolic rewiring. |
| first_indexed | 2024-03-09T16:59:14Z |
| format | Article |
| id | doaj.art-1175cc983bdf46fdbc2ac098b882bf94 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T16:59:14Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-1175cc983bdf46fdbc2ac098b882bf942023-11-24T14:31:55ZengMDPI AGBiomolecules2218-273X2023-11-011311160410.3390/biom13111604Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer CellsHuda I. Atiya0Grace Gorecki1Geyon L. Garcia2Leonard G. Frisbie3Roja Baruwal4Lan Coffman5Division of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15261, USADivision of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15261, USAMedical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Integrative Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USAMolecular Pharmacology Graduate Program, University of Pittsburgh, Pittsburgh, PA 15261, USADivision of Hematology/Oncology, Department of Medicine, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15261, USAThe ability of cancer cells to detach from the primary site and metastasize is the main cause of cancer- related death among all cancer types. Epithelial-to-mesenchymal transition (EMT) is the first event of the metastatic cascade, resulting in the loss of cell–cell adhesion and the acquisition of motile and stem-like phenotypes. A critical modulator of EMT in cancer cells is the stromal tumor microenvironment (TME), which can promote the acquisition of a mesenchymal phenotype through direct interaction with cancer cells or changes to the broader microenvironment. In this review, we will explore the role of stromal cells in modulating cancer cell EMT, with particular emphasis on the function of mesenchymal stromal/stem cells (MSCs) through the activation of EMT-inducing pathways, extra cellular matrix (ECM) remodeling, immune cell alteration, and metabolic rewiring.https://www.mdpi.com/2218-273X/13/11/1604mesenchymal stem cellsdirect and indirect interactionECM remodelingreprograming |
| spellingShingle | Huda I. Atiya Grace Gorecki Geyon L. Garcia Leonard G. Frisbie Roja Baruwal Lan Coffman Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells Biomolecules mesenchymal stem cells direct and indirect interaction ECM remodeling reprograming |
| title | Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells |
| title_full | Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells |
| title_fullStr | Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells |
| title_full_unstemmed | Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells |
| title_short | Stromal-Modulated Epithelial-to-Mesenchymal Transition in Cancer Cells |
| title_sort | stromal modulated epithelial to mesenchymal transition in cancer cells |
| topic | mesenchymal stem cells direct and indirect interaction ECM remodeling reprograming |
| url | https://www.mdpi.com/2218-273X/13/11/1604 |
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