Elevated CD39+T-Regulatory Cells and Reduced Levels of Adenosine Indicate a Role for Tolerogenic Signals in the Progression from Moderate to Severe COVID-19

Elevated CD39+T-Regulatory Cells and Reduced Levels of Adenosine Indicate a Role for Tolerogenic Signals in the Progression from Moderate to Severe COVID-19

Viral infections trigger inflammation by controlling ATP release. CD39 ectoenzymes hydrolyze ATP/ADP to AMP, which is converted by CD73 into anti-inflammatory adenosine (ADO). ADO is an anti-inflammatory and immunosuppressant molecule which can enhance viral persistence and severity. The CD39-CD73-a...

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Bibliographic Details
Main Authors: Alaa Elsaghir, Ehsan M. W. El-Sabaa, Asmaa M. Zahran, Sahar A. Mandour, Eman H. Salama, Sahar Aboulfotuh, Reham M. El-Morshedy, Stefania Tocci, Ahmed Mohamed Mandour, Wael Esmat Ali, Lobna Abdel-Wahid, Ibrahim M. Sayed, Mohamed A. El-Mokhtar
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
COVID-19
T-regulatory cells
ATP
CD39
CD73
adenosine
Online Access:https://www.mdpi.com/1422-0067/24/24/17614

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