Biomimicking Atherosclerotic Vessels: A Relevant and (Yet) Sub-Explored Topic
Atherosclerosis represents the etiologic source of several cardiovascular events, including myocardial infarction, cerebrovascular accidents, and peripheral artery disease, which remain the leading cause of mortality in the world. Numerous strategies are being delineated to revert the non-optimal pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biomimetics |
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| Online Access: | https://www.mdpi.com/2313-7673/9/3/135 |
| _version_ | 1797241910623993856 |
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| author | Joana Henriques Ana M. Amaro Ana P. Piedade |
| author_facet | Joana Henriques Ana M. Amaro Ana P. Piedade |
| author_sort | Joana Henriques |
| collection | DOAJ |
| description | Atherosclerosis represents the etiologic source of several cardiovascular events, including myocardial infarction, cerebrovascular accidents, and peripheral artery disease, which remain the leading cause of mortality in the world. Numerous strategies are being delineated to revert the non-optimal projections of the World Health Organization, by both designing new diagnostic and therapeutic approaches or improving the interventional procedures performed by physicians. Deeply understanding the pathological process of atherosclerosis is, therefore, mandatory to accomplish improved results in these trials. Due to their availability, reproducibility, low expensiveness, and rapid production, biomimicking physical models are preferred over animal experimentation because they can overcome some limitations, mainly related to replicability and ethical issues. Their capability to represent any atherosclerotic stage and/or plaque type makes them valuable tools to investigate hemodynamical, pharmacodynamical, and biomechanical behaviors, as well as to optimize imaging systems and, thus, obtain meaningful prospects to improve the efficacy and effectiveness of treatment on a patient-specific basis. However, the broadness of possible applications in which these biomodels can be used is associated with a wide range of tissue-mimicking materials that are selected depending on the final purpose of the model and, consequently, prioritizing some materials’ properties over others. This review aims to summarize the progress in fabricating biomimicking atherosclerotic models, mainly focusing on using materials according to the intended application. |
| first_indexed | 2024-04-24T18:30:50Z |
| format | Article |
| id | doaj.art-117729ae5ae54be6ae90ebea1cdb6200 |
| institution | Directory Open Access Journal |
| issn | 2313-7673 |
| language | English |
| last_indexed | 2024-04-24T18:30:50Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj.art-117729ae5ae54be6ae90ebea1cdb62002024-03-27T13:27:36ZengMDPI AGBiomimetics2313-76732024-02-019313510.3390/biomimetics9030135Biomimicking Atherosclerotic Vessels: A Relevant and (Yet) Sub-Explored TopicJoana Henriques0Ana M. Amaro1Ana P. Piedade2University of Coimbra, CEMMPRE, ARISE, Department of Mechanical Engineering, 3030-788 Coimbra, PortugalUniversity of Coimbra, CEMMPRE, ARISE, Department of Mechanical Engineering, 3030-788 Coimbra, PortugalUniversity of Coimbra, CEMMPRE, ARISE, Department of Mechanical Engineering, 3030-788 Coimbra, PortugalAtherosclerosis represents the etiologic source of several cardiovascular events, including myocardial infarction, cerebrovascular accidents, and peripheral artery disease, which remain the leading cause of mortality in the world. Numerous strategies are being delineated to revert the non-optimal projections of the World Health Organization, by both designing new diagnostic and therapeutic approaches or improving the interventional procedures performed by physicians. Deeply understanding the pathological process of atherosclerosis is, therefore, mandatory to accomplish improved results in these trials. Due to their availability, reproducibility, low expensiveness, and rapid production, biomimicking physical models are preferred over animal experimentation because they can overcome some limitations, mainly related to replicability and ethical issues. Their capability to represent any atherosclerotic stage and/or plaque type makes them valuable tools to investigate hemodynamical, pharmacodynamical, and biomechanical behaviors, as well as to optimize imaging systems and, thus, obtain meaningful prospects to improve the efficacy and effectiveness of treatment on a patient-specific basis. However, the broadness of possible applications in which these biomodels can be used is associated with a wide range of tissue-mimicking materials that are selected depending on the final purpose of the model and, consequently, prioritizing some materials’ properties over others. This review aims to summarize the progress in fabricating biomimicking atherosclerotic models, mainly focusing on using materials according to the intended application.https://www.mdpi.com/2313-7673/9/3/135atherosclerosisplaque typesmulticomponentsbiomimicking modelsvascular modelsbiomechanics |
| spellingShingle | Joana Henriques Ana M. Amaro Ana P. Piedade Biomimicking Atherosclerotic Vessels: A Relevant and (Yet) Sub-Explored Topic Biomimetics atherosclerosis plaque types multicomponents biomimicking models vascular models biomechanics |
| title | Biomimicking Atherosclerotic Vessels: A Relevant and (Yet) Sub-Explored Topic |
| title_full | Biomimicking Atherosclerotic Vessels: A Relevant and (Yet) Sub-Explored Topic |
| title_fullStr | Biomimicking Atherosclerotic Vessels: A Relevant and (Yet) Sub-Explored Topic |
| title_full_unstemmed | Biomimicking Atherosclerotic Vessels: A Relevant and (Yet) Sub-Explored Topic |
| title_short | Biomimicking Atherosclerotic Vessels: A Relevant and (Yet) Sub-Explored Topic |
| title_sort | biomimicking atherosclerotic vessels a relevant and yet sub explored topic |
| topic | atherosclerosis plaque types multicomponents biomimicking models vascular models biomechanics |
| url | https://www.mdpi.com/2313-7673/9/3/135 |
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