Mangiferin inhibits chronic stress-induced tumor growth in colorectal liver metastases via WAVE2 signaling pathway
Background: Evidence indicates that chronic stress promotes progression of colorectal liver metastases (CLM). Mangiferin is the active chemical constituent of the rhizomes of Anemarrhena asphodeloides Bunge. Mangiferin (MGF) exerts anti-inflammatory, anti-proliferative, anti-angiogenic, anti-fibroti...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402300960X |
| _version_ | 1797851893926461440 |
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| author | Yiming Tao Xuefei Tian Jia Luo Hongyi Zhu Yi Chu Lei Pei |
| author_facet | Yiming Tao Xuefei Tian Jia Luo Hongyi Zhu Yi Chu Lei Pei |
| author_sort | Yiming Tao |
| collection | DOAJ |
| description | Background: Evidence indicates that chronic stress promotes progression of colorectal liver metastases (CLM). Mangiferin is the active chemical constituent of the rhizomes of Anemarrhena asphodeloides Bunge. Mangiferin (MGF) exerts anti-inflammatory, anti-proliferative, anti-angiogenic, anti-fibrotic and antioxidant effects in a variety of cancers. Its mechanism in chronic stress and tumor growth is still poorly understood. Methods: To investigate the effects of MGF on the CLM and tumor-associated depression, activated hepatic stellate cells (a-HSCs), HT-29 CRC cells, were used in chronic unpredictable mild stress (CUMS) of tumor-bearing models. Potential antidepressant activity was determined by FST, TST, SIT and serum cytokine (IL-6, IL-18 and TNF-α) examination. Downstream signaling molecules were detected by Western blot, immunohistochemistry and fluorescence microscopy. Results: CUMS induced depression behavior and depression-related cytokines and promoted tumor growth in CLM. MGF-treated mice significantly improved chronic stress behaviors by reducing depression-related cytokines. In addition, MGF treatment inhibits WAVE2 signaling pathway, leading to TGF-β1 induced HSC inhibition, thereby reducing depressive behavior and tumor growth in CLM. Conclusion: MGF can alleviate CUMS induced tumor growth and the treatment of CLM patients with MGF may be beneficial. |
| first_indexed | 2024-04-09T19:25:12Z |
| format | Article |
| id | doaj.art-11777aa72f5f44e59ea0cdf6e2d0db9c |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:25:12Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-11777aa72f5f44e59ea0cdf6e2d0db9c2023-04-05T08:16:02ZengElsevierHeliyon2405-84402023-03-0193e13753Mangiferin inhibits chronic stress-induced tumor growth in colorectal liver metastases via WAVE2 signaling pathwayYiming Tao0Xuefei Tian1Jia Luo2Hongyi Zhu3Yi Chu4Lei Pei5Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, ChinaDepartment of Internal Medicine, College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, 410208, ChinaDepartment of Surgery, Hunan Cancer Hospital, Affiliated Tumor Hospital of Central South University, Changsha, Hunan, 410013, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, 410011, China; Research Center of Digestive Disease, Central South University, Changsha, Hunan, 410011, ChinaDepartment of Gastroenterology, The Second Xiangya Hospital, Central South University, 410011, China; Research Center of Digestive Disease, Central South University, Changsha, Hunan, 410011, ChinaDepartment of General Surgery, The Second Xiangya Hospital, Central South University, 410011, China; Corresponding author. Department of General Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, 410011, Changsha, China.Background: Evidence indicates that chronic stress promotes progression of colorectal liver metastases (CLM). Mangiferin is the active chemical constituent of the rhizomes of Anemarrhena asphodeloides Bunge. Mangiferin (MGF) exerts anti-inflammatory, anti-proliferative, anti-angiogenic, anti-fibrotic and antioxidant effects in a variety of cancers. Its mechanism in chronic stress and tumor growth is still poorly understood. Methods: To investigate the effects of MGF on the CLM and tumor-associated depression, activated hepatic stellate cells (a-HSCs), HT-29 CRC cells, were used in chronic unpredictable mild stress (CUMS) of tumor-bearing models. Potential antidepressant activity was determined by FST, TST, SIT and serum cytokine (IL-6, IL-18 and TNF-α) examination. Downstream signaling molecules were detected by Western blot, immunohistochemistry and fluorescence microscopy. Results: CUMS induced depression behavior and depression-related cytokines and promoted tumor growth in CLM. MGF-treated mice significantly improved chronic stress behaviors by reducing depression-related cytokines. In addition, MGF treatment inhibits WAVE2 signaling pathway, leading to TGF-β1 induced HSC inhibition, thereby reducing depressive behavior and tumor growth in CLM. Conclusion: MGF can alleviate CUMS induced tumor growth and the treatment of CLM patients with MGF may be beneficial.http://www.sciencedirect.com/science/article/pii/S240584402300960XChronic stressColorectal liver metastasesMangiferin |
| spellingShingle | Yiming Tao Xuefei Tian Jia Luo Hongyi Zhu Yi Chu Lei Pei Mangiferin inhibits chronic stress-induced tumor growth in colorectal liver metastases via WAVE2 signaling pathway Heliyon Chronic stress Colorectal liver metastases Mangiferin |
| title | Mangiferin inhibits chronic stress-induced tumor growth in colorectal liver metastases via WAVE2 signaling pathway |
| title_full | Mangiferin inhibits chronic stress-induced tumor growth in colorectal liver metastases via WAVE2 signaling pathway |
| title_fullStr | Mangiferin inhibits chronic stress-induced tumor growth in colorectal liver metastases via WAVE2 signaling pathway |
| title_full_unstemmed | Mangiferin inhibits chronic stress-induced tumor growth in colorectal liver metastases via WAVE2 signaling pathway |
| title_short | Mangiferin inhibits chronic stress-induced tumor growth in colorectal liver metastases via WAVE2 signaling pathway |
| title_sort | mangiferin inhibits chronic stress induced tumor growth in colorectal liver metastases via wave2 signaling pathway |
| topic | Chronic stress Colorectal liver metastases Mangiferin |
| url | http://www.sciencedirect.com/science/article/pii/S240584402300960X |
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