COVID-19: Ivermectin; Molecular Mechanisms, Limitations, Suggestions
To date, no effective treatment has been found against coronaviruses (CoVs), which have re-emerged with severe acute respiratory syndrome CoV-2 (SARS-CoV-2) and have a high potential for disease in humans as well as domestic and wild animal species. The investigation of treatment options to combat t...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2020-12-01
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| Series: | Bezmiâlem Science |
| Subjects: | |
| Online Access: |
http://bezmialemscience.org/archives/archive-detail/article-preview/covd-19-vermectin-molecular-mechanisms-limitations/42779
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| _version_ | 1797915074147385344 |
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| author | Mustafa KESMEN Ceren ANLAŞ Tülay BAKIREL Eray Metin GÜLER |
| author_facet | Mustafa KESMEN Ceren ANLAŞ Tülay BAKIREL Eray Metin GÜLER |
| author_sort | Mustafa KESMEN |
| collection | DOAJ |
| description | To date, no effective treatment has been found against coronaviruses (CoVs), which have re-emerged with severe acute respiratory syndrome CoV-2 (SARS-CoV-2) and have a high potential for disease in humans as well as domestic and wild animal species. The investigation of treatment options to combat this virus, which has a pandemic character with its high morbidity and mortality rate, is a multidisciplinary research subject. In this context, the drug repositioning has come to the agenda in the fight against SARS-CoV- 2, which is the current subject. However, despite the superior characteristics of drug options other than rational usage purposes such as easy accessibility and rapid transfer to the field, the lack of evaluations for their efficacy and safety may lead to misleading. In this review, the applicability, risks, and possible molecular mechanisms of ivermectin, which is suggested to be an effective treatment option, are discussed within the framework of the pharmacokinetic and toxicokinetic properties of the drug. |
| first_indexed | 2024-04-10T12:35:55Z |
| format | Article |
| id | doaj.art-117a39331ccb4b6384afc5987914216d |
| institution | Directory Open Access Journal |
| issn | 2148-2373 2148-2373 |
| language | English |
| last_indexed | 2024-04-10T12:35:55Z |
| publishDate | 2020-12-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Bezmiâlem Science |
| spelling | doaj.art-117a39331ccb4b6384afc5987914216d2023-02-15T16:14:34ZengGalenos Publishing HouseBezmiâlem Science2148-23732148-23732020-12-0183949810.14235/bas.galenos.2020.465513049054COVID-19: Ivermectin; Molecular Mechanisms, Limitations, SuggestionsMustafa KESMEN0Ceren ANLAŞ1Tülay BAKIREL2Eray Metin GÜLER3 İstanbul Pendik Veterinary Control Institute, Drug Quality Control Laboratory, İstanbul, Turkey İstanbul University Cerrahpaşa Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, İstanbul, Turkey İstanbul University Cerrahpaşa Faculty of Veterinary Medicine, Department of Pharmacology and Toxicology, İstanbul, Turkey Bezmialem Vakıf University Faculty of Medicine, Department of Medical Biochemistry, İstanbul, Turkey To date, no effective treatment has been found against coronaviruses (CoVs), which have re-emerged with severe acute respiratory syndrome CoV-2 (SARS-CoV-2) and have a high potential for disease in humans as well as domestic and wild animal species. The investigation of treatment options to combat this virus, which has a pandemic character with its high morbidity and mortality rate, is a multidisciplinary research subject. In this context, the drug repositioning has come to the agenda in the fight against SARS-CoV- 2, which is the current subject. However, despite the superior characteristics of drug options other than rational usage purposes such as easy accessibility and rapid transfer to the field, the lack of evaluations for their efficacy and safety may lead to misleading. In this review, the applicability, risks, and possible molecular mechanisms of ivermectin, which is suggested to be an effective treatment option, are discussed within the framework of the pharmacokinetic and toxicokinetic properties of the drug. http://bezmialemscience.org/archives/archive-detail/article-preview/covd-19-vermectin-molecular-mechanisms-limitations/42779 antiviral efficacycovid-19drug repurposingivermectinsars-cov-2 |
| spellingShingle | Mustafa KESMEN Ceren ANLAŞ Tülay BAKIREL Eray Metin GÜLER COVID-19: Ivermectin; Molecular Mechanisms, Limitations, Suggestions Bezmiâlem Science antiviral efficacy covid-19 drug repurposing ivermectin sars-cov-2 |
| title | COVID-19: Ivermectin; Molecular Mechanisms, Limitations, Suggestions |
| title_full | COVID-19: Ivermectin; Molecular Mechanisms, Limitations, Suggestions |
| title_fullStr | COVID-19: Ivermectin; Molecular Mechanisms, Limitations, Suggestions |
| title_full_unstemmed | COVID-19: Ivermectin; Molecular Mechanisms, Limitations, Suggestions |
| title_short | COVID-19: Ivermectin; Molecular Mechanisms, Limitations, Suggestions |
| title_sort | covid 19 ivermectin molecular mechanisms limitations suggestions |
| topic | antiviral efficacy covid-19 drug repurposing ivermectin sars-cov-2 |
| url |
http://bezmialemscience.org/archives/archive-detail/article-preview/covd-19-vermectin-molecular-mechanisms-limitations/42779
|
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