Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7T MRI
Hippocampal atrophy, amyloid plaques, and neurofibrillary tangles are established pathologic markers of Alzheimer's disease. We analyzed the temporal lobes of 9 Alzheimer's dementia (AD) and 7 cognitively normal (NC) subjects. Brains were scanned post-mortem at 7Tesla. We extracted hippoca...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158217300979 |
| _version_ | 1811283721269018624 |
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| author | Anna E. Blanken Sona Hurtz Chris Zarow Kristina Biado Hedieh Honarpisheh Johanne Somme Jenny Brook Spencer Tung Emily Kraft Darrick Lo Denise W. Ng Harry V. Vinters Liana G. Apostolova |
| author_facet | Anna E. Blanken Sona Hurtz Chris Zarow Kristina Biado Hedieh Honarpisheh Johanne Somme Jenny Brook Spencer Tung Emily Kraft Darrick Lo Denise W. Ng Harry V. Vinters Liana G. Apostolova |
| author_sort | Anna E. Blanken |
| collection | DOAJ |
| description | Hippocampal atrophy, amyloid plaques, and neurofibrillary tangles are established pathologic markers of Alzheimer's disease. We analyzed the temporal lobes of 9 Alzheimer's dementia (AD) and 7 cognitively normal (NC) subjects. Brains were scanned post-mortem at 7Tesla. We extracted hippocampal volumes and radial distances using automated segmentation techniques. Hippocampal slices were stained for amyloid beta (Aβ), tau, and cresyl violet to evaluate neuronal counts. The hippocampal subfields, CA1, CA2, CA3, CA4, and subiculum were manually traced so that the neuronal counts, Aβ, and tau burden could be obtained for each region. We used linear regression to detect associations between hippocampal atrophy in 3D, clinical diagnosis and total as well as subfield pathology burden measures. As expected, we found significant correlations between hippocampal radial distance and mean neuronal count, as well as diagnosis. There were subfield specific associations between hippocampal radial distance and tau in CA2, and cresyl violet neuronal counts in CA1 and subiculum. These results provide further validation for the European Alzheimer's Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP). Keywords: Alzheimer's disease, Imaging, MRI, Neuropathology, Brain atrophy, Hippocampus |
| first_indexed | 2024-04-13T02:16:39Z |
| format | Article |
| id | doaj.art-117a945c54b44e578c567f7c2b11485d |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-13T02:16:39Z |
| publishDate | 2017-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-117a945c54b44e578c567f7c2b11485d2022-12-22T03:07:07ZengElsevierNeuroImage: Clinical2213-15822017-01-01155661Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7T MRIAnna E. Blanken0Sona Hurtz1Chris Zarow2Kristina Biado3Hedieh Honarpisheh4Johanne Somme5Jenny Brook6Spencer Tung7Emily Kraft8Darrick Lo9Denise W. Ng10Harry V. Vinters11Liana G. Apostolova12Department of Psychology, University of Southern California, Los Angeles, CA, USADrexel University College of Medicine, Philadelphia, PA, USADepartment of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USADepartment of Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, USADepartment of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USADepartment of Neurology, Barakaldo, Basque Country, SpainDepartment of Medicine - Statistics Core, UCLA, Los Angeles, CA, USADepartment of Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, USAUniversity of Rochester, Rochester, N.Y, USADepartment of Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, USADepartment of Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, USADepartment of Pathology & Laboratory Medicine, UCLA, Los Angeles, CA, USADepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA; Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA; Corresponding author at: 355 W. 16th Street, Suite 4100, Indianapolis, IN 46202, USA.Hippocampal atrophy, amyloid plaques, and neurofibrillary tangles are established pathologic markers of Alzheimer's disease. We analyzed the temporal lobes of 9 Alzheimer's dementia (AD) and 7 cognitively normal (NC) subjects. Brains were scanned post-mortem at 7Tesla. We extracted hippocampal volumes and radial distances using automated segmentation techniques. Hippocampal slices were stained for amyloid beta (Aβ), tau, and cresyl violet to evaluate neuronal counts. The hippocampal subfields, CA1, CA2, CA3, CA4, and subiculum were manually traced so that the neuronal counts, Aβ, and tau burden could be obtained for each region. We used linear regression to detect associations between hippocampal atrophy in 3D, clinical diagnosis and total as well as subfield pathology burden measures. As expected, we found significant correlations between hippocampal radial distance and mean neuronal count, as well as diagnosis. There were subfield specific associations between hippocampal radial distance and tau in CA2, and cresyl violet neuronal counts in CA1 and subiculum. These results provide further validation for the European Alzheimer's Disease Consortium Alzheimer's Disease Neuroimaging Initiative Center Harmonized Hippocampal Segmentation Protocol (HarP). Keywords: Alzheimer's disease, Imaging, MRI, Neuropathology, Brain atrophy, Hippocampushttp://www.sciencedirect.com/science/article/pii/S2213158217300979 |
| spellingShingle | Anna E. Blanken Sona Hurtz Chris Zarow Kristina Biado Hedieh Honarpisheh Johanne Somme Jenny Brook Spencer Tung Emily Kraft Darrick Lo Denise W. Ng Harry V. Vinters Liana G. Apostolova Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7T MRI NeuroImage: Clinical |
| title | Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7T MRI |
| title_full | Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7T MRI |
| title_fullStr | Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7T MRI |
| title_full_unstemmed | Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7T MRI |
| title_short | Associations between hippocampal morphometry and neuropathologic markers of Alzheimer's disease using 7T MRI |
| title_sort | associations between hippocampal morphometry and neuropathologic markers of alzheimer s disease using 7t mri |
| url | http://www.sciencedirect.com/science/article/pii/S2213158217300979 |
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