Primary gynecologic melanoma: A report of two unusual cases
Background: Primary ovarian and cervical melanomas are extremely rare tumors with a poor prognosis. Diagnosis requires a high index of suspicion as presentation can mimic benign conditions clinically and other neoplasms histologically. Cases: A 41 year-old with an adnexal mass underwent surgical sta...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Gynecologic Oncology Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578915000041 |
| _version_ | 1828155047665467392 |
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| author | Jessica L. Berger Daman Samrao Marilyn Huang Alexander B. Olawaiye |
| author_facet | Jessica L. Berger Daman Samrao Marilyn Huang Alexander B. Olawaiye |
| author_sort | Jessica L. Berger |
| collection | DOAJ |
| description | Background: Primary ovarian and cervical melanomas are extremely rare tumors with a poor prognosis. Diagnosis requires a high index of suspicion as presentation can mimic benign conditions clinically and other neoplasms histologically.
Cases: A 41 year-old with an adnexal mass underwent surgical staging for a stage IA ovarian melanoma. Imaging revealed a brain metastasis treated with radiation. Subsequent nodal recurrence was treated with immune and targeted therapies. She is alive with disease at 61 months follow-up. A 54 year-old presented after endocervical melanoma was diagnosed with polypectomy. She underwent radical hysterectomy, lymphadenectomy, and adjuvant brachytherapy. Immediate post-treatment imaging revealed widespread liver and pulmonary metastasis, currently being treated with ipilimumab.
Conclusion: Immunohistochemistry can facilitate the diagnosis of gynecologic melanoma, and multidisciplinary treatment is recommended. |
| first_indexed | 2024-04-11T22:47:43Z |
| format | Article |
| id | doaj.art-117b66b869b4474bb4c783d41ac60bf9 |
| institution | Directory Open Access Journal |
| issn | 2352-5789 |
| language | English |
| last_indexed | 2024-04-11T22:47:43Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj.art-117b66b869b4474bb4c783d41ac60bf92022-12-22T03:58:41ZengElsevierGynecologic Oncology Reports2352-57892015-01-0111C313310.1016/j.gore.2015.01.003Primary gynecologic melanoma: A report of two unusual casesJessica L. Berger0Daman Samrao1Marilyn Huang2Alexander B. Olawaiye3Division of Gynecologic Oncology at Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesDepartment of Pathology at Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesDivision of Gynecologic Oncology at Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesDivision of Gynecologic Oncology at Magee-Women's Hospital of the University of Pittsburgh Medical Center, Pittsburgh, PA, United StatesBackground: Primary ovarian and cervical melanomas are extremely rare tumors with a poor prognosis. Diagnosis requires a high index of suspicion as presentation can mimic benign conditions clinically and other neoplasms histologically. Cases: A 41 year-old with an adnexal mass underwent surgical staging for a stage IA ovarian melanoma. Imaging revealed a brain metastasis treated with radiation. Subsequent nodal recurrence was treated with immune and targeted therapies. She is alive with disease at 61 months follow-up. A 54 year-old presented after endocervical melanoma was diagnosed with polypectomy. She underwent radical hysterectomy, lymphadenectomy, and adjuvant brachytherapy. Immediate post-treatment imaging revealed widespread liver and pulmonary metastasis, currently being treated with ipilimumab. Conclusion: Immunohistochemistry can facilitate the diagnosis of gynecologic melanoma, and multidisciplinary treatment is recommended.http://www.sciencedirect.com/science/article/pii/S2352578915000041Cervical melanomaOvarian melanomaImmunotherapyMultidisciplinary treatment |
| spellingShingle | Jessica L. Berger Daman Samrao Marilyn Huang Alexander B. Olawaiye Primary gynecologic melanoma: A report of two unusual cases Gynecologic Oncology Reports Cervical melanoma Ovarian melanoma Immunotherapy Multidisciplinary treatment |
| title | Primary gynecologic melanoma: A report of two unusual cases |
| title_full | Primary gynecologic melanoma: A report of two unusual cases |
| title_fullStr | Primary gynecologic melanoma: A report of two unusual cases |
| title_full_unstemmed | Primary gynecologic melanoma: A report of two unusual cases |
| title_short | Primary gynecologic melanoma: A report of two unusual cases |
| title_sort | primary gynecologic melanoma a report of two unusual cases |
| topic | Cervical melanoma Ovarian melanoma Immunotherapy Multidisciplinary treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2352578915000041 |
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