Phenolic constituents from twigs of Aleurites fordii and their biological activities

Three new neolignan glycosides (1–3), a new phenolic glycoside (15), and a new cyanoglycoside (16) were isolated and characterized from the twigs of Aleurites fordii together with 14 known analogues (4–14 and 17–19). The structural elucidation of the new compounds was performed through the analysis...

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Main Authors: Kyoung Jin Park, Won Se Suh, Da Hye Yoon, Chung Sub Kim, Sun Yeou Kim, Kang Ro Lee
Format: Article
Language:English
Published: Beilstein-Institut 2021-09-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.17.151
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author Kyoung Jin Park
Won Se Suh
Da Hye Yoon
Chung Sub Kim
Sun Yeou Kim
Kang Ro Lee
author_facet Kyoung Jin Park
Won Se Suh
Da Hye Yoon
Chung Sub Kim
Sun Yeou Kim
Kang Ro Lee
author_sort Kyoung Jin Park
collection DOAJ
description Three new neolignan glycosides (1–3), a new phenolic glycoside (15), and a new cyanoglycoside (16) were isolated and characterized from the twigs of Aleurites fordii together with 14 known analogues (4–14 and 17–19). The structural elucidation of the new compounds was performed through the analysis of their NMR, HRMS, and ECD spectra and by chemical methods. All isolated compounds were tested for their antineuroinflammatory and neuroprotective activities.
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spelling doaj.art-117b747928d84cd8bd348405c8700a432022-12-21T23:30:45ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972021-09-011712329233910.3762/bjoc.17.1511860-5397-17-151Phenolic constituents from twigs of Aleurites fordii and their biological activitiesKyoung Jin Park0Won Se Suh1Da Hye Yoon2Chung Sub Kim3Sun Yeou Kim4Kang Ro Lee5Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of KoreaNatural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of KoreaLaboratory of Pharmacognosy, College of Pharmacy, Gachon University, Incheon, 21936, Republic of KoreaNatural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of KoreaLaboratory of Pharmacognosy, College of Pharmacy, Gachon University, Incheon, 21936, Republic of KoreaNatural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of KoreaThree new neolignan glycosides (1–3), a new phenolic glycoside (15), and a new cyanoglycoside (16) were isolated and characterized from the twigs of Aleurites fordii together with 14 known analogues (4–14 and 17–19). The structural elucidation of the new compounds was performed through the analysis of their NMR, HRMS, and ECD spectra and by chemical methods. All isolated compounds were tested for their antineuroinflammatory and neuroprotective activities.https://doi.org/10.3762/bjoc.17.151aleurites fordiiantineuroinflammationeuphorbiaceaeneolignan glycosideneuroprotective activityphenolic compound
spellingShingle Kyoung Jin Park
Won Se Suh
Da Hye Yoon
Chung Sub Kim
Sun Yeou Kim
Kang Ro Lee
Phenolic constituents from twigs of Aleurites fordii and their biological activities
Beilstein Journal of Organic Chemistry
aleurites fordii
antineuroinflammation
euphorbiaceae
neolignan glycoside
neuroprotective activity
phenolic compound
title Phenolic constituents from twigs of Aleurites fordii and their biological activities
title_full Phenolic constituents from twigs of Aleurites fordii and their biological activities
title_fullStr Phenolic constituents from twigs of Aleurites fordii and their biological activities
title_full_unstemmed Phenolic constituents from twigs of Aleurites fordii and their biological activities
title_short Phenolic constituents from twigs of Aleurites fordii and their biological activities
title_sort phenolic constituents from twigs of aleurites fordii and their biological activities
topic aleurites fordii
antineuroinflammation
euphorbiaceae
neolignan glycoside
neuroprotective activity
phenolic compound
url https://doi.org/10.3762/bjoc.17.151
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