Large A-fiber activity is required for microglial proliferation and p38 MAPK activation in the spinal cord: different effects of resiniferatoxin and bupivacaine on spinal microglial changes after spared nerve injury

<p>Abstract</p> <p>Background</p> <p>After peripheral nerve injury, spontaneous ectopic activity arising from the peripheral axons plays an important role in inducing central sensitization and neuropathic pain. Recent evidence indicates that activation of spinal cord mi...

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Bibliographic Details
Main Authors: Decosterd Isabelle, Gao Yong-Jing, Berta Temugin, Suter Marc R, Ji Ru-Rong
Format: Article
Language:English
Published: SAGE Publishing 2009-09-01
Series:Molecular Pain
Online Access:http://www.molecularpain.com/content/5/1/53