RAGE plays key role in diabetic retinopathy: a review
Abstract RAGE is a multiligand receptor for the immunoglobulin superfamily of cell surface molecules and is expressed in Müller cells, vascular endothelial cells, nerve cells and RPE cells of the retina. Diabetic retinopathy (DR) is a multifactorial disease associated with retinal inflammation and v...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BioMedical Engineering OnLine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12938-023-01194-9 |
| _version_ | 1797376818318147584 |
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| author | ZhiWen Lu Bin Fan YunZhi Li YiXin Zhang |
| author_facet | ZhiWen Lu Bin Fan YunZhi Li YiXin Zhang |
| author_sort | ZhiWen Lu |
| collection | DOAJ |
| description | Abstract RAGE is a multiligand receptor for the immunoglobulin superfamily of cell surface molecules and is expressed in Müller cells, vascular endothelial cells, nerve cells and RPE cells of the retina. Diabetic retinopathy (DR) is a multifactorial disease associated with retinal inflammation and vascular abnormalities and is the leading cause of vision loss or impairment in older or working-age adults worldwide. Therapies aimed at reducing the inflammatory response and unnecessary angiogenesis can help slow the progression of DR, which in turn can save patients’ vision. To maximize the efficacy and minimize the side effects, treatments that target key players in the pathophysiological process of DR need to be developed. The interaction between RAGE and its ligands is involved in a variety of cytopathological alterations in the retina, including secretion of inflammatory factors, regulation of angiogenesis, oxidative stress, structural and functional changes, and neurodegeneration. In this review, we will summarize the pathologic pathways mediated by RAGE and its ligand interactions and discuss its role in the progression of diabetic retinopathy to explore potential therapeutic targets that are effective and safe for DR. |
| first_indexed | 2024-03-08T19:45:06Z |
| format | Article |
| id | doaj.art-117ebd54fc4e4efda8047c74a800b1e2 |
| institution | Directory Open Access Journal |
| issn | 1475-925X |
| language | English |
| last_indexed | 2024-03-08T19:45:06Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj.art-117ebd54fc4e4efda8047c74a800b1e22023-12-24T12:24:51ZengBMCBioMedical Engineering OnLine1475-925X2023-12-0122111210.1186/s12938-023-01194-9RAGE plays key role in diabetic retinopathy: a reviewZhiWen Lu0Bin Fan1YunZhi Li2YiXin Zhang3Department of Ophthalmology, The Second Hospital of Jilin University, Nanguan DistrictDepartment of Ophthalmology, The Second Hospital of Jilin University, Nanguan DistrictDepartment of Ophthalmology, The Second Hospital of Jilin University, Nanguan DistrictDepartment of Ophthalmology, The Second Hospital of Jilin University, Nanguan DistrictAbstract RAGE is a multiligand receptor for the immunoglobulin superfamily of cell surface molecules and is expressed in Müller cells, vascular endothelial cells, nerve cells and RPE cells of the retina. Diabetic retinopathy (DR) is a multifactorial disease associated with retinal inflammation and vascular abnormalities and is the leading cause of vision loss or impairment in older or working-age adults worldwide. Therapies aimed at reducing the inflammatory response and unnecessary angiogenesis can help slow the progression of DR, which in turn can save patients’ vision. To maximize the efficacy and minimize the side effects, treatments that target key players in the pathophysiological process of DR need to be developed. The interaction between RAGE and its ligands is involved in a variety of cytopathological alterations in the retina, including secretion of inflammatory factors, regulation of angiogenesis, oxidative stress, structural and functional changes, and neurodegeneration. In this review, we will summarize the pathologic pathways mediated by RAGE and its ligand interactions and discuss its role in the progression of diabetic retinopathy to explore potential therapeutic targets that are effective and safe for DR.https://doi.org/10.1186/s12938-023-01194-9RAGEAGENF-κBHMGB1Diabetic retinopathyInflammation |
| spellingShingle | ZhiWen Lu Bin Fan YunZhi Li YiXin Zhang RAGE plays key role in diabetic retinopathy: a review BioMedical Engineering OnLine RAGE AGE NF-κB HMGB1 Diabetic retinopathy Inflammation |
| title | RAGE plays key role in diabetic retinopathy: a review |
| title_full | RAGE plays key role in diabetic retinopathy: a review |
| title_fullStr | RAGE plays key role in diabetic retinopathy: a review |
| title_full_unstemmed | RAGE plays key role in diabetic retinopathy: a review |
| title_short | RAGE plays key role in diabetic retinopathy: a review |
| title_sort | rage plays key role in diabetic retinopathy a review |
| topic | RAGE AGE NF-κB HMGB1 Diabetic retinopathy Inflammation |
| url | https://doi.org/10.1186/s12938-023-01194-9 |
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