Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development
The authors identify Nuclear receptor subfamily 6 group A member 1 (Nr6a1) as a master regulator of elongation, segmentation, patterning and lineage allocation specifically within the trunk region of the mouse, acting downstream of the major signals known to control vertebral column formation.
| Main Authors: | , , , , , , , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
Nature Portfolio
2022-12-01
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| 叢編: | Nature Communications |
| 在線閱讀: | https://doi.org/10.1038/s41467-022-35303-4 |
| _version_ | 1828265120711573504 |
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| author | Yi-Cheng Chang Jan Manent Jan Schroeder Siew Fen Lisa Wong Gabriel M. Hauswirth Natalia A. Shylo Emma L. Moore Annita Achilleos Victoria Garside Jose M. Polo Paul Trainor Edwina McGlinn |
| author_facet | Yi-Cheng Chang Jan Manent Jan Schroeder Siew Fen Lisa Wong Gabriel M. Hauswirth Natalia A. Shylo Emma L. Moore Annita Achilleos Victoria Garside Jose M. Polo Paul Trainor Edwina McGlinn |
| author_sort | Yi-Cheng Chang |
| collection | DOAJ |
| description | The authors identify Nuclear receptor subfamily 6 group A member 1 (Nr6a1) as a master regulator of elongation, segmentation, patterning and lineage allocation specifically within the trunk region of the mouse, acting downstream of the major signals known to control vertebral column formation. |
| first_indexed | 2024-04-13T04:34:44Z |
| format | Article |
| id | doaj.art-117f96f9c40b48e6a5318dfb51a9856a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T04:34:44Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-117f96f9c40b48e6a5318dfb51a9856a2022-12-22T03:02:13ZengNature PortfolioNature Communications2041-17232022-12-0113111910.1038/s41467-022-35303-4Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk developmentYi-Cheng Chang0Jan Manent1Jan Schroeder2Siew Fen Lisa Wong3Gabriel M. Hauswirth4Natalia A. Shylo5Emma L. Moore6Annita Achilleos7Victoria Garside8Jose M. Polo9Paul Trainor10Edwina McGlinn11EMBL Australia, Monash UniversityEMBL Australia, Monash UniversityAustralian Regenerative Medicine Institute, Monash UniversityEMBL Australia, Monash UniversityEMBL Australia, Monash UniversityStowers Institute for Medical ResearchStowers Institute for Medical ResearchStowers Institute for Medical ResearchEMBL Australia, Monash UniversityAustralian Regenerative Medicine Institute, Monash UniversityStowers Institute for Medical ResearchEMBL Australia, Monash UniversityThe authors identify Nuclear receptor subfamily 6 group A member 1 (Nr6a1) as a master regulator of elongation, segmentation, patterning and lineage allocation specifically within the trunk region of the mouse, acting downstream of the major signals known to control vertebral column formation.https://doi.org/10.1038/s41467-022-35303-4 |
| spellingShingle | Yi-Cheng Chang Jan Manent Jan Schroeder Siew Fen Lisa Wong Gabriel M. Hauswirth Natalia A. Shylo Emma L. Moore Annita Achilleos Victoria Garside Jose M. Polo Paul Trainor Edwina McGlinn Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development Nature Communications |
| title | Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development |
| title_full | Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development |
| title_fullStr | Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development |
| title_full_unstemmed | Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development |
| title_short | Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development |
| title_sort | nr6a1 controls hox expression dynamics and is a master regulator of vertebrate trunk development |
| url | https://doi.org/10.1038/s41467-022-35303-4 |
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