Multidetector Computed Tomography Perfusion in Head and Neck Squamous Cell Carcinomas: Evaluation of a Dose Reduction Strategy
Background Computed tomography perfusion (CTp), a useful technique in oncology, is not widely utilized due to the high radiation dose delivered from it. It involves scanning the region of interest every second for 50 seconds following intravenous contrast administration. Doubling sampling interval (...
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| Format: | Article |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2022-12-01
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| Series: | Indian Journal of Radiology and Imaging |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1753469 |
| _version_ | 1811215753728229376 |
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| author | Shuchi Bhatt Samrat Mandal Gopesh Mehrotra Vipin Arora Usharani Singh |
| author_facet | Shuchi Bhatt Samrat Mandal Gopesh Mehrotra Vipin Arora Usharani Singh |
| author_sort | Shuchi Bhatt |
| collection | DOAJ |
| description | Background Computed tomography perfusion (CTp), a useful technique in oncology, is not widely utilized due to the high radiation dose delivered from it. It involves scanning the region of interest every second for 50 seconds following intravenous contrast administration. Doubling sampling interval (SI) to 2 seconds will half the radiation dose, but may impact its effectiveness, which needs to be evaluated.
Objectives To evaluate a dose reduction strategy in CTp by determining agreement between standard dose (SD) CTp (acquisition with SI 1 second) and low-dose CTp techniques with SI of 2 seconds (achieved either by reconstruction only or true low-dose acquisition).
Materials and methods This cross-sectional study was conducted on histopathology-proven head and neck squamous cell carcinoma (HNSCC) patients who underwent CTp on 64 slice multidetector CT. A total of 56 patients had SD and 24 patients underwent true low dose (LD) acquisition. SD data were also reconstructed at SI 2 seconds to obtain a dataset simulating low dose (low-dose reconstruction [LDr]). Paired t-test was applied to compare CTp in SD and LDr groups and the Bland–Altman plot drawn to calculate 95% confidence limit of agreement. The Kolmogorov–Smirnov test compared CTp parameters for LDr and LD groups.
Results There was no statistical difference in CTp parameters (except blood flow in malignant) in SD and LDr groups for both malignant and normal tissues. CTp of malignant tissue was not statistically different in LDr and LD groups but the radiation dose was half in the LD group.
Conclusion Reduction of radiation dose to half achieved by doubling the SI does not affect the CTp parameters significantly. So LD acquisitions will increase the use of CTp in HNSCC. |
| first_indexed | 2024-04-12T06:27:44Z |
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| issn | 0971-3026 1998-3808 |
| language | English |
| last_indexed | 2024-04-12T06:27:44Z |
| publishDate | 2022-12-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Radiology and Imaging |
| spelling | doaj.art-11818f73151f4f2f828236e054e2208a2022-12-22T03:44:05ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Radiology and Imaging0971-30261998-38082022-12-01320445145910.1055/s-0042-1753469Multidetector Computed Tomography Perfusion in Head and Neck Squamous Cell Carcinomas: Evaluation of a Dose Reduction StrategyShuchi Bhatt0Samrat Mandal1Gopesh Mehrotra2Vipin Arora3Usharani Singh4Department of Radio-diagnosis, University College of Medical Sciences, University of Delhi, Delhi, IndiaDepartment of Radio-diagnosis, University College of Medical Sciences, University of Delhi, Delhi, IndiaDepartment of Radio-diagnosis, University College of Medical Sciences, University of Delhi, Delhi, IndiaDepartment of Otorhinolaryngology, University College of Medical Sciences, University of Delhi, Delhi, IndiaDepartment of Pathology, University College of Medical Sciences, University of Delhi, Delhi, IndiaBackground Computed tomography perfusion (CTp), a useful technique in oncology, is not widely utilized due to the high radiation dose delivered from it. It involves scanning the region of interest every second for 50 seconds following intravenous contrast administration. Doubling sampling interval (SI) to 2 seconds will half the radiation dose, but may impact its effectiveness, which needs to be evaluated. Objectives To evaluate a dose reduction strategy in CTp by determining agreement between standard dose (SD) CTp (acquisition with SI 1 second) and low-dose CTp techniques with SI of 2 seconds (achieved either by reconstruction only or true low-dose acquisition). Materials and methods This cross-sectional study was conducted on histopathology-proven head and neck squamous cell carcinoma (HNSCC) patients who underwent CTp on 64 slice multidetector CT. A total of 56 patients had SD and 24 patients underwent true low dose (LD) acquisition. SD data were also reconstructed at SI 2 seconds to obtain a dataset simulating low dose (low-dose reconstruction [LDr]). Paired t-test was applied to compare CTp in SD and LDr groups and the Bland–Altman plot drawn to calculate 95% confidence limit of agreement. The Kolmogorov–Smirnov test compared CTp parameters for LDr and LD groups. Results There was no statistical difference in CTp parameters (except blood flow in malignant) in SD and LDr groups for both malignant and normal tissues. CTp of malignant tissue was not statistically different in LDr and LD groups but the radiation dose was half in the LD group. Conclusion Reduction of radiation dose to half achieved by doubling the SI does not affect the CTp parameters significantly. So LD acquisitions will increase the use of CTp in HNSCC.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1753469ct perfusionsampling intervaldose reductionhead and necksquamous cell carcinoma |
| spellingShingle | Shuchi Bhatt Samrat Mandal Gopesh Mehrotra Vipin Arora Usharani Singh Multidetector Computed Tomography Perfusion in Head and Neck Squamous Cell Carcinomas: Evaluation of a Dose Reduction Strategy Indian Journal of Radiology and Imaging ct perfusion sampling interval dose reduction head and neck squamous cell carcinoma |
| title | Multidetector Computed Tomography Perfusion in Head and Neck Squamous Cell Carcinomas: Evaluation of a Dose Reduction Strategy |
| title_full | Multidetector Computed Tomography Perfusion in Head and Neck Squamous Cell Carcinomas: Evaluation of a Dose Reduction Strategy |
| title_fullStr | Multidetector Computed Tomography Perfusion in Head and Neck Squamous Cell Carcinomas: Evaluation of a Dose Reduction Strategy |
| title_full_unstemmed | Multidetector Computed Tomography Perfusion in Head and Neck Squamous Cell Carcinomas: Evaluation of a Dose Reduction Strategy |
| title_short | Multidetector Computed Tomography Perfusion in Head and Neck Squamous Cell Carcinomas: Evaluation of a Dose Reduction Strategy |
| title_sort | multidetector computed tomography perfusion in head and neck squamous cell carcinomas evaluation of a dose reduction strategy |
| topic | ct perfusion sampling interval dose reduction head and neck squamous cell carcinoma |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1753469 |
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