Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota
Sepsis is described as an immune response disorder of the host to infection in which microorganisms play a non-negligible role. Most survivors of sepsis experience ICU-acquired weakness, also known as septic myopathy, characterized by skeletal muscle atrophy, weakness, and irreparable damage/regener...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-07-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223006273 |
| _version_ | 1797822098734841856 |
|---|---|
| author | Yukun Liu Ligang Xu Zhaohui Yang Dongfang Wang Tianyu Li Fan Yang Zhanfei Li Xiangjun Bai Yuchang Wang |
| author_facet | Yukun Liu Ligang Xu Zhaohui Yang Dongfang Wang Tianyu Li Fan Yang Zhanfei Li Xiangjun Bai Yuchang Wang |
| author_sort | Yukun Liu |
| collection | DOAJ |
| description | Sepsis is described as an immune response disorder of the host to infection in which microorganisms play a non-negligible role. Most survivors of sepsis experience ICU-acquired weakness, also known as septic myopathy, characterized by skeletal muscle atrophy, weakness, and irreparable damage/regenerated or dysfunctional. The mechanism of sepsis-induced myopathy is currently unclear. It has been believed that this state is triggered by circulating pathogens and their related harmful factors, leading to impaired muscle metabolism. Sepsis and its resulting alterations in the intestinal microbiota are associated with sepsis-related organ dysfunction, including skeletal muscle wasting. There are also some studies on interventions targeting the flora, including fecal microbiota transplants, the addition of dietary fiber and probiotics in enteral feeding products, etc., aiming to improve sepsis-related myopathy. In this review, we critically assess the potential mechanisms and therapeutic prospects of intestinal flora in the development of septic myopathy. |
| first_indexed | 2024-03-13T10:02:51Z |
| format | Article |
| id | doaj.art-1181b53ae2fd4d5c9ce28f659c56bf5c |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-13T10:02:51Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-1181b53ae2fd4d5c9ce28f659c56bf5c2023-05-23T04:21:15ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-07-01163114837Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiotaYukun Liu0Ligang Xu1Zhaohui Yang2Dongfang Wang3Tianyu Li4Fan Yang5Zhanfei Li6Xiangjun Bai7Yuchang Wang8Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR ChinaTrauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR ChinaDepartment of Orthopaedics, the Affiliated Minda Hospital of Hubei Minzu University, Enshi 445000, Hubei, PR ChinaTrauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR ChinaTrauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR ChinaTrauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR ChinaTrauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR ChinaTrauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR ChinaTrauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China; Corresponding author.Sepsis is described as an immune response disorder of the host to infection in which microorganisms play a non-negligible role. Most survivors of sepsis experience ICU-acquired weakness, also known as septic myopathy, characterized by skeletal muscle atrophy, weakness, and irreparable damage/regenerated or dysfunctional. The mechanism of sepsis-induced myopathy is currently unclear. It has been believed that this state is triggered by circulating pathogens and their related harmful factors, leading to impaired muscle metabolism. Sepsis and its resulting alterations in the intestinal microbiota are associated with sepsis-related organ dysfunction, including skeletal muscle wasting. There are also some studies on interventions targeting the flora, including fecal microbiota transplants, the addition of dietary fiber and probiotics in enteral feeding products, etc., aiming to improve sepsis-related myopathy. In this review, we critically assess the potential mechanisms and therapeutic prospects of intestinal flora in the development of septic myopathy.http://www.sciencedirect.com/science/article/pii/S0753332223006273Muscle atrophyICUAWMicrobiomeInfectionSepsis-induced myopathy |
| spellingShingle | Yukun Liu Ligang Xu Zhaohui Yang Dongfang Wang Tianyu Li Fan Yang Zhanfei Li Xiangjun Bai Yuchang Wang Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota Biomedicine & Pharmacotherapy Muscle atrophy ICUAW Microbiome Infection Sepsis-induced myopathy |
| title | Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota |
| title_full | Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota |
| title_fullStr | Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota |
| title_full_unstemmed | Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota |
| title_short | Gut-muscle axis and sepsis-induced myopathy: The potential role of gut microbiota |
| title_sort | gut muscle axis and sepsis induced myopathy the potential role of gut microbiota |
| topic | Muscle atrophy ICUAW Microbiome Infection Sepsis-induced myopathy |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223006273 |
| work_keys_str_mv | AT yukunliu gutmuscleaxisandsepsisinducedmyopathythepotentialroleofgutmicrobiota AT ligangxu gutmuscleaxisandsepsisinducedmyopathythepotentialroleofgutmicrobiota AT zhaohuiyang gutmuscleaxisandsepsisinducedmyopathythepotentialroleofgutmicrobiota AT dongfangwang gutmuscleaxisandsepsisinducedmyopathythepotentialroleofgutmicrobiota AT tianyuli gutmuscleaxisandsepsisinducedmyopathythepotentialroleofgutmicrobiota AT fanyang gutmuscleaxisandsepsisinducedmyopathythepotentialroleofgutmicrobiota AT zhanfeili gutmuscleaxisandsepsisinducedmyopathythepotentialroleofgutmicrobiota AT xiangjunbai gutmuscleaxisandsepsisinducedmyopathythepotentialroleofgutmicrobiota AT yuchangwang gutmuscleaxisandsepsisinducedmyopathythepotentialroleofgutmicrobiota |