Diagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analyses
Objective: This review aims to conduct a comprehensive study of the diagnostic accuracy of interleukin-6 (IL-6) for multiple diseases by utilizing existing systematic reviews and meta-analyses. Methods: We performed a thorough search of Embase, Web of Science, PubMed, and Cochrane Database of System...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024038003 |
| _version_ | 1797224174472658944 |
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| author | Zeyu Han Jin Li Xianyanling Yi Tianyi Zhang Dazhou Liao Jia You Jianzhong Ai |
| author_facet | Zeyu Han Jin Li Xianyanling Yi Tianyi Zhang Dazhou Liao Jia You Jianzhong Ai |
| author_sort | Zeyu Han |
| collection | DOAJ |
| description | Objective: This review aims to conduct a comprehensive study of the diagnostic accuracy of interleukin-6 (IL-6) for multiple diseases by utilizing existing systematic reviews and meta-analyses. Methods: We performed a thorough search of Embase, Web of Science, PubMed, and Cochrane Database of Systematic Reviews up to April 2023 to gather meta-analyses that investigate the diagnostic accuracy of IL-6. To assess the methodological quality of the studies, we employed the Assessing the Methodological Quality of Systematic Reviews-2 and Grading of Recommendations, Assessment, Development and Evaluation criteria. Results: We included 34 meta-analyses out of the 3024 articles retrieved from the search. These meta-analyses covered 9 categories of diseases of the International Classification of Diseases-11. Studies rated as ''Critically Low'' or ''Very Low'' in the quality assessment process were excluded, resulting in a total of 6 meta-analyses that encompassed sepsis, colorectal cancer, tuberculous pleural effusion (TPE), endometriosis, among others. Among these diseases, IL-6 demonstrated a relatively high diagnostic potential in accurately identifying TPE and endometriosis. Conclusions: IL-6 exhibited favorable diagnostic accuracy across multiple diseases, suggesting its potential as a reliable diagnostic biomarker in the near future. Substantial evidence supported its high diagnostic accuracy, particularly in the cases of TPE and endometriosis. |
| first_indexed | 2024-04-24T13:48:56Z |
| format | Article |
| id | doaj.art-11833218d5a64ecba262451907e36ee3 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:48:56Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-11833218d5a64ecba262451907e36ee32024-04-04T05:05:51ZengElsevierHeliyon2405-84402024-03-01106e27769Diagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analysesZeyu Han0Jin Li1Xianyanling Yi2Tianyi Zhang3Dazhou Liao4Jia You5Jianzhong Ai6Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 88 South Keyuan Road, Chengdu, 610041, PR ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, 88 South Keyuan Road, Chengdu, 610041, PR ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, 88 South Keyuan Road, Chengdu, 610041, PR ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, 88 South Keyuan Road, Chengdu, 610041, PR ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, 88 South Keyuan Road, Chengdu, 610041, PR ChinaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, 88 South Keyuan Road, Chengdu, 610041, PR ChinaCorresponding author. Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 88 South Keyuan Road, Chengdu, 610041, PR China.; Department of Urology, Institute of Urology, West China Hospital, Sichuan University, 88 South Keyuan Road, Chengdu, 610041, PR ChinaObjective: This review aims to conduct a comprehensive study of the diagnostic accuracy of interleukin-6 (IL-6) for multiple diseases by utilizing existing systematic reviews and meta-analyses. Methods: We performed a thorough search of Embase, Web of Science, PubMed, and Cochrane Database of Systematic Reviews up to April 2023 to gather meta-analyses that investigate the diagnostic accuracy of IL-6. To assess the methodological quality of the studies, we employed the Assessing the Methodological Quality of Systematic Reviews-2 and Grading of Recommendations, Assessment, Development and Evaluation criteria. Results: We included 34 meta-analyses out of the 3024 articles retrieved from the search. These meta-analyses covered 9 categories of diseases of the International Classification of Diseases-11. Studies rated as ''Critically Low'' or ''Very Low'' in the quality assessment process were excluded, resulting in a total of 6 meta-analyses that encompassed sepsis, colorectal cancer, tuberculous pleural effusion (TPE), endometriosis, among others. Among these diseases, IL-6 demonstrated a relatively high diagnostic potential in accurately identifying TPE and endometriosis. Conclusions: IL-6 exhibited favorable diagnostic accuracy across multiple diseases, suggesting its potential as a reliable diagnostic biomarker in the near future. Substantial evidence supported its high diagnostic accuracy, particularly in the cases of TPE and endometriosis.http://www.sciencedirect.com/science/article/pii/S2405844024038003Interleukin-6Umbrella reviewDiagnostic accuracyDiseasemeta-Analysis |
| spellingShingle | Zeyu Han Jin Li Xianyanling Yi Tianyi Zhang Dazhou Liao Jia You Jianzhong Ai Diagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analyses Heliyon Interleukin-6 Umbrella review Diagnostic accuracy Disease meta-Analysis |
| title | Diagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analyses |
| title_full | Diagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analyses |
| title_fullStr | Diagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analyses |
| title_full_unstemmed | Diagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analyses |
| title_short | Diagnostic accuracy of interleukin-6 in multiple diseases: An umbrella review of meta-analyses |
| title_sort | diagnostic accuracy of interleukin 6 in multiple diseases an umbrella review of meta analyses |
| topic | Interleukin-6 Umbrella review Diagnostic accuracy Disease meta-Analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024038003 |
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