Anidulafungin in the treatment of invasive fungal infections
Kathryn Sabol, Tawanda GumboUniversity of Texas Southwestern Medical Center, Dallas, TX, USAAbstract: More antifungal agents have reached clinical use in the past two decades than at any other time. The echinocandins have been a welcome addition to this group, with the latest being anidulafungin. Th...
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2008-03-01
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| Series: | Therapeutics and Clinical Risk Management |
| Online Access: | http://www.dovepress.com/anidulafungin-in-the-treatment-of-invasive-fungal-infections-a1294 |
| _version_ | 1818461543304527872 |
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| author | Kathryn Sabol Tawanda Gumbo |
| author_facet | Kathryn Sabol Tawanda Gumbo |
| author_sort | Kathryn Sabol |
| collection | DOAJ |
| description | Kathryn Sabol, Tawanda GumboUniversity of Texas Southwestern Medical Center, Dallas, TX, USAAbstract: More antifungal agents have reached clinical use in the past two decades than at any other time. The echinocandins have been a welcome addition to this group, with the latest being anidulafungin. There are several lines of evidence to support anidulafungin’s role as primary therapy for the treatment of invasive candidiasis in non-neutropenic patients, and as alternative therapy to fluconazole in patients with esophageal candidiasis with azole intolerance or triazole-resistant Candida. Pharmacokinetic–pharmacodynamic studies in animals have demonstrated superior efficacy, defined as maximal microbial kill, when compared to fluconazole, regardless of the fluconazole susceptibility of the Candida species. These studies, as well as dose-effect studies in patients, also support the currently recommended dose of anidulafungin. A well designed randomized controlled trial has demonstrated anidulafungin’s efficacy in patients with invasive candidiasis. In this paper, we argue that anidulafungin may be preferable to fluconazole for the treatment of candidemia. However, as of yet, the difference between anidulafungin and the other two licensed echinocandins as first-line therapy for invasive candidiasis is unclear. On the other hand, there is insufficient evidence as of yet to support first-line use of anidulafungin in patients with neutropenia or aspergillosis.Keywords: anidulafungin, pharmacokinetics-pharmacodynamics, efficacy, candidiasis |
| first_indexed | 2024-12-14T23:47:49Z |
| format | Article |
| id | doaj.art-118380ad50c1404b89355ab8d817eedd |
| institution | Directory Open Access Journal |
| issn | 1176-6336 1178-203X |
| language | English |
| last_indexed | 2024-12-14T23:47:49Z |
| publishDate | 2008-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj.art-118380ad50c1404b89355ab8d817eedd2022-12-21T22:43:20ZengDove Medical PressTherapeutics and Clinical Risk Management1176-63361178-203X2008-03-012008Issue 17178Anidulafungin in the treatment of invasive fungal infectionsKathryn SabolTawanda GumboKathryn Sabol, Tawanda GumboUniversity of Texas Southwestern Medical Center, Dallas, TX, USAAbstract: More antifungal agents have reached clinical use in the past two decades than at any other time. The echinocandins have been a welcome addition to this group, with the latest being anidulafungin. There are several lines of evidence to support anidulafungin’s role as primary therapy for the treatment of invasive candidiasis in non-neutropenic patients, and as alternative therapy to fluconazole in patients with esophageal candidiasis with azole intolerance or triazole-resistant Candida. Pharmacokinetic–pharmacodynamic studies in animals have demonstrated superior efficacy, defined as maximal microbial kill, when compared to fluconazole, regardless of the fluconazole susceptibility of the Candida species. These studies, as well as dose-effect studies in patients, also support the currently recommended dose of anidulafungin. A well designed randomized controlled trial has demonstrated anidulafungin’s efficacy in patients with invasive candidiasis. In this paper, we argue that anidulafungin may be preferable to fluconazole for the treatment of candidemia. However, as of yet, the difference between anidulafungin and the other two licensed echinocandins as first-line therapy for invasive candidiasis is unclear. On the other hand, there is insufficient evidence as of yet to support first-line use of anidulafungin in patients with neutropenia or aspergillosis.Keywords: anidulafungin, pharmacokinetics-pharmacodynamics, efficacy, candidiasishttp://www.dovepress.com/anidulafungin-in-the-treatment-of-invasive-fungal-infections-a1294 |
| spellingShingle | Kathryn Sabol Tawanda Gumbo Anidulafungin in the treatment of invasive fungal infections Therapeutics and Clinical Risk Management |
| title | Anidulafungin in the treatment of invasive fungal infections |
| title_full | Anidulafungin in the treatment of invasive fungal infections |
| title_fullStr | Anidulafungin in the treatment of invasive fungal infections |
| title_full_unstemmed | Anidulafungin in the treatment of invasive fungal infections |
| title_short | Anidulafungin in the treatment of invasive fungal infections |
| title_sort | anidulafungin in the treatment of invasive fungal infections |
| url | http://www.dovepress.com/anidulafungin-in-the-treatment-of-invasive-fungal-infections-a1294 |
| work_keys_str_mv | AT kathrynsabol anidulafungininthetreatmentofinvasivefungalinfections AT tawandagumbo anidulafungininthetreatmentofinvasivefungalinfections |