Trans Species RNA Activity: Sperm RNA of the Father of an Autistic Child Programs Glial Cells and Behavioral Disorders in Mice
Recently, we described the alteration of six miRNAs in the serum of autistic children, their fathers, mothers, siblings, and in the sperm of autistic mouse models. Studies in model organisms suggest that noncoding RNAs participate in transcriptional modulation pathways. Using mice, approaches to alt...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/14/2/201 |
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| author | Zeynep Yilmaz Sukranli Keziban Korkmaz Bayram Ecmel Mehmetbeyoglu Zuleyha Doganyigit Feyzullah Beyaz Elif Funda Sener Serpil Taheri Yusuf Ozkul Minoo Rassoulzadegan |
| author_facet | Zeynep Yilmaz Sukranli Keziban Korkmaz Bayram Ecmel Mehmetbeyoglu Zuleyha Doganyigit Feyzullah Beyaz Elif Funda Sener Serpil Taheri Yusuf Ozkul Minoo Rassoulzadegan |
| author_sort | Zeynep Yilmaz Sukranli |
| collection | DOAJ |
| description | Recently, we described the alteration of six miRNAs in the serum of autistic children, their fathers, mothers, siblings, and in the sperm of autistic mouse models. Studies in model organisms suggest that noncoding RNAs participate in transcriptional modulation pathways. Using mice, approaches to alter the amount of RNA in fertilized eggs enable in vivo intervention at an early stage of development. Noncoding RNAs are very numerous in spermatozoa. Our study addresses a fundamental question: can the transfer of RNA content from sperm to eggs result in changes in phenotypic traits, such as autism? To explore this, we used sperm RNA from a normal father but with autistic children to create mouse models for autism. Here, we induced, in a single step by microinjecting sperm RNA into fertilized mouse eggs, a transcriptional alteration with the transformation in adults of glial cells into cells affected by astrogliosis and microgliosis developing deficiency disorders of the ‘autism-like’ type in mice born following these manipulations. Human sperm RNA alters gene expression in mice, and validates the possibility of non-Mendelian inheritance in autism. |
| first_indexed | 2024-03-07T22:40:19Z |
| format | Article |
| id | doaj.art-1184744af79549c988e597d18396455f |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-07T22:40:19Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-1184744af79549c988e597d18396455f2024-02-23T15:09:21ZengMDPI AGBiomolecules2218-273X2024-02-0114220110.3390/biom14020201Trans Species RNA Activity: Sperm RNA of the Father of an Autistic Child Programs Glial Cells and Behavioral Disorders in MiceZeynep Yilmaz Sukranli0Keziban Korkmaz Bayram1Ecmel Mehmetbeyoglu2Zuleyha Doganyigit3Feyzullah Beyaz4Elif Funda Sener5Serpil Taheri6Yusuf Ozkul7Minoo Rassoulzadegan8Betul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri 38039, TurkeyBetul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri 38039, TurkeyBetul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri 38039, TurkeyHistology and Embryology Department, Medical Faculty, Yozgat Bozok University, Yozgat 66700, TurkeyHistology and Embryology Department, Faculty of Veterinary, Erciyes University, Kayseri 38039, TurkeyBetul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri 38039, TurkeyBetul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri 38039, TurkeyBetul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri 38039, TurkeyBetul-Ziya Eren Genome and Stem Cell Center, Erciyes University, Kayseri 38039, TurkeyRecently, we described the alteration of six miRNAs in the serum of autistic children, their fathers, mothers, siblings, and in the sperm of autistic mouse models. Studies in model organisms suggest that noncoding RNAs participate in transcriptional modulation pathways. Using mice, approaches to alter the amount of RNA in fertilized eggs enable in vivo intervention at an early stage of development. Noncoding RNAs are very numerous in spermatozoa. Our study addresses a fundamental question: can the transfer of RNA content from sperm to eggs result in changes in phenotypic traits, such as autism? To explore this, we used sperm RNA from a normal father but with autistic children to create mouse models for autism. Here, we induced, in a single step by microinjecting sperm RNA into fertilized mouse eggs, a transcriptional alteration with the transformation in adults of glial cells into cells affected by astrogliosis and microgliosis developing deficiency disorders of the ‘autism-like’ type in mice born following these manipulations. Human sperm RNA alters gene expression in mice, and validates the possibility of non-Mendelian inheritance in autism.https://www.mdpi.com/2218-273X/14/2/201non-MendelianautismheredityspermmicroRNAstranscription |
| spellingShingle | Zeynep Yilmaz Sukranli Keziban Korkmaz Bayram Ecmel Mehmetbeyoglu Zuleyha Doganyigit Feyzullah Beyaz Elif Funda Sener Serpil Taheri Yusuf Ozkul Minoo Rassoulzadegan Trans Species RNA Activity: Sperm RNA of the Father of an Autistic Child Programs Glial Cells and Behavioral Disorders in Mice Biomolecules non-Mendelian autism heredity sperm microRNAs transcription |
| title | Trans Species RNA Activity: Sperm RNA of the Father of an Autistic Child Programs Glial Cells and Behavioral Disorders in Mice |
| title_full | Trans Species RNA Activity: Sperm RNA of the Father of an Autistic Child Programs Glial Cells and Behavioral Disorders in Mice |
| title_fullStr | Trans Species RNA Activity: Sperm RNA of the Father of an Autistic Child Programs Glial Cells and Behavioral Disorders in Mice |
| title_full_unstemmed | Trans Species RNA Activity: Sperm RNA of the Father of an Autistic Child Programs Glial Cells and Behavioral Disorders in Mice |
| title_short | Trans Species RNA Activity: Sperm RNA of the Father of an Autistic Child Programs Glial Cells and Behavioral Disorders in Mice |
| title_sort | trans species rna activity sperm rna of the father of an autistic child programs glial cells and behavioral disorders in mice |
| topic | non-Mendelian autism heredity sperm microRNAs transcription |
| url | https://www.mdpi.com/2218-273X/14/2/201 |
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