Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasis
The immunopathology associated with Leishmaniasis is a consequence of inflammation. Upon infection with Leishmania, the type of host-immune response is determinant for the clinical manifestations that can lead to either self-healing or chronic disease. Multiple pathways may determine disease severit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.974051/full |
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| author | Tirza Gabrielle Ramos de Mesquita Tirza Gabrielle Ramos de Mesquita José do Espírito Santo Junior José do Espírito Santo Junior Luan Diego Oliveira da Silva George Allan Villarouco Silva Felipe Jules de Araújo Felipe Jules de Araújo Suzana Kanawati Pinheiro Suzana Kanawati Pinheiro Herllon Karllos Athaydes Kerr Lener Santos da Silva Lener Santos da Silva Luciane Macedo de Souza Samir Assad de Almeida Krys Layane Guimarães Duarte Queiroz Josué Lacerda de Souza Josué Lacerda de Souza Cilana Chagas da Silva Héctor David Graterol Sequera Héctor David Graterol Sequera Mara Lúcia Gomes de Souza Mara Lúcia Gomes de Souza Anderson Nogueira Barbosa Gemilson Soares Pontes Gemilson Soares Pontes Gemilson Soares Pontes Marcus Vinitius de Farias Guerra Marcus Vinitius de Farias Guerra Rajendranath Ramasawmy Rajendranath Ramasawmy Rajendranath Ramasawmy Rajendranath Ramasawmy |
| author_facet | Tirza Gabrielle Ramos de Mesquita Tirza Gabrielle Ramos de Mesquita José do Espírito Santo Junior José do Espírito Santo Junior Luan Diego Oliveira da Silva George Allan Villarouco Silva Felipe Jules de Araújo Felipe Jules de Araújo Suzana Kanawati Pinheiro Suzana Kanawati Pinheiro Herllon Karllos Athaydes Kerr Lener Santos da Silva Lener Santos da Silva Luciane Macedo de Souza Samir Assad de Almeida Krys Layane Guimarães Duarte Queiroz Josué Lacerda de Souza Josué Lacerda de Souza Cilana Chagas da Silva Héctor David Graterol Sequera Héctor David Graterol Sequera Mara Lúcia Gomes de Souza Mara Lúcia Gomes de Souza Anderson Nogueira Barbosa Gemilson Soares Pontes Gemilson Soares Pontes Gemilson Soares Pontes Marcus Vinitius de Farias Guerra Marcus Vinitius de Farias Guerra Rajendranath Ramasawmy Rajendranath Ramasawmy Rajendranath Ramasawmy Rajendranath Ramasawmy |
| author_sort | Tirza Gabrielle Ramos de Mesquita |
| collection | DOAJ |
| description | The immunopathology associated with Leishmaniasis is a consequence of inflammation. Upon infection with Leishmania, the type of host-immune response is determinant for the clinical manifestations that can lead to either self-healing or chronic disease. Multiple pathways may determine disease severity. A comparison of systemic immune profiles in patients with cutaneous leishmaniasis caused by L. guyanensis and healthy individuals with the same socio-epidemiological characteristics coming from the same endemic areas as the patients is performed to identify particular immune profile and pathways associated with the progression of disease development. Twenty-seven plasma soluble circulating factors were evaluated between the groups by univariate and multivariate analysis. The following biomarkers pairs IL-17/IL-9 (ρ=0,829), IL-17/IL-12 (ρ=0,786), IL-6/IL-1ra (ρ=0,785), IL-6/IL-12 (ρ=0,780), IL-1β/G-CSF (ρ=0,758) and IL-17/MIP-1β (ρ=0,754) showed the highest correlation mean among the patient while only INF-γ/IL-4 (ρ=0.740), 17/MIP-1β (ρ=0,712) and IL-17/IL-9 (ρ=0,707) exhibited positive correlation among the control group. The cytokine IL-17 and IL1β presented the greater number of positive pair correlation among the patients. The linear combinations of biomarkers displayed IP-10, IL-2 and RANTES as the variables with the higher discriminatory activity in the patient group compared to PDGF, IL-1ra and eotaxin among the control subjects. IP-10, IL-2, IL-1β, RANTES and IL-17 seem to be predictive value of progression to the development of disease among the Lg-infected individuals. |
| first_indexed | 2024-12-11T00:27:36Z |
| format | Article |
| id | doaj.art-118631cf6fba4aaea63ed666c7b1e8dd |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T00:27:36Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-118631cf6fba4aaea63ed666c7b1e8dd2022-12-22T01:27:28ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.974051974051Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasisTirza Gabrielle Ramos de Mesquita0Tirza Gabrielle Ramos de Mesquita1José do Espírito Santo Junior2José do Espírito Santo Junior3Luan Diego Oliveira da Silva4George Allan Villarouco Silva5Felipe Jules de Araújo6Felipe Jules de Araújo7Suzana Kanawati Pinheiro8Suzana Kanawati Pinheiro9Herllon Karllos Athaydes Kerr10Lener Santos da Silva11Lener Santos da Silva12Luciane Macedo de Souza13Samir Assad de Almeida14Krys Layane Guimarães Duarte Queiroz15Josué Lacerda de Souza16Josué Lacerda de Souza17Cilana Chagas da Silva18Héctor David Graterol Sequera19Héctor David Graterol Sequera20Mara Lúcia Gomes de Souza21Mara Lúcia Gomes de Souza22Anderson Nogueira Barbosa23Gemilson Soares Pontes24Gemilson Soares Pontes25Gemilson Soares Pontes26Marcus Vinitius de Farias Guerra27Marcus Vinitius de Farias Guerra28Rajendranath Ramasawmy29Rajendranath Ramasawmy30Rajendranath Ramasawmy31Rajendranath Ramasawmy32Programa de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, BrazilDepartment of Molecular Biology, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, Manaus, Amazonas, BrazilFaculdade de Medicina Nilton Lins, Universidade Nilton Lins, Manaus, BrazilFaculdade de Medicina Nilton Lins, Universidade Nilton Lins, Manaus, BrazilPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, Manaus, Amazonas, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, BrazilFaculdade de Medicina Nilton Lins, Universidade Nilton Lins, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, BrazilDepartment of Molecular Biology, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, BrazilDepartment of Molecular Biology, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, BrazilFaculdade de Medicina Nilton Lins, Universidade Nilton Lins, Manaus, BrazilDepartment of Molecular Biology, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, Manaus, Amazonas, BrazilFaculdade de Medicina Nilton Lins, Universidade Nilton Lins, Manaus, BrazilDepartment of Molecular Biology, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, BrazilDepartment of Molecular Biology, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, BrazilDepartment of Molecular Biology, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilDepartment of Virology, Instituto Nacional de Pesquisas da Amazônia, Manaus, BrazilPrograma de Pós-Graduação em Imunologia Básica e Aplicada, Instituto de Ciências Biológicas, Universidade Federal do Amazonas, Manaus, Amazonas, BrazilDepartment of Virology, Instituto Nacional de Pesquisas da Amazônia, Manaus, BrazilGenomic Health Surveillance Network: Optimization of Assistance and Research in The State of Amazonas – REGESAM, Manaus, Amazonas, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, BrazilDepartment of Molecular Biology, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilPrograma de Pós-Graduação em Medicina Tropical, Universidade do Estado do Amazonas, Manaus, BrazilDepartment of Molecular Biology, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, BrazilFaculdade de Medicina Nilton Lins, Universidade Nilton Lins, Manaus, BrazilGenomic Health Surveillance Network: Optimization of Assistance and Research in The State of Amazonas – REGESAM, Manaus, Amazonas, BrazilThe immunopathology associated with Leishmaniasis is a consequence of inflammation. Upon infection with Leishmania, the type of host-immune response is determinant for the clinical manifestations that can lead to either self-healing or chronic disease. Multiple pathways may determine disease severity. A comparison of systemic immune profiles in patients with cutaneous leishmaniasis caused by L. guyanensis and healthy individuals with the same socio-epidemiological characteristics coming from the same endemic areas as the patients is performed to identify particular immune profile and pathways associated with the progression of disease development. Twenty-seven plasma soluble circulating factors were evaluated between the groups by univariate and multivariate analysis. The following biomarkers pairs IL-17/IL-9 (ρ=0,829), IL-17/IL-12 (ρ=0,786), IL-6/IL-1ra (ρ=0,785), IL-6/IL-12 (ρ=0,780), IL-1β/G-CSF (ρ=0,758) and IL-17/MIP-1β (ρ=0,754) showed the highest correlation mean among the patient while only INF-γ/IL-4 (ρ=0.740), 17/MIP-1β (ρ=0,712) and IL-17/IL-9 (ρ=0,707) exhibited positive correlation among the control group. The cytokine IL-17 and IL1β presented the greater number of positive pair correlation among the patients. The linear combinations of biomarkers displayed IP-10, IL-2 and RANTES as the variables with the higher discriminatory activity in the patient group compared to PDGF, IL-1ra and eotaxin among the control subjects. IP-10, IL-2, IL-1β, RANTES and IL-17 seem to be predictive value of progression to the development of disease among the Lg-infected individuals.https://www.frontiersin.org/articles/10.3389/fimmu.2022.974051/fullLeishmania guyanensiscytokineschemokinescutaneous leishmaniasisgrowth factors |
| spellingShingle | Tirza Gabrielle Ramos de Mesquita Tirza Gabrielle Ramos de Mesquita José do Espírito Santo Junior José do Espírito Santo Junior Luan Diego Oliveira da Silva George Allan Villarouco Silva Felipe Jules de Araújo Felipe Jules de Araújo Suzana Kanawati Pinheiro Suzana Kanawati Pinheiro Herllon Karllos Athaydes Kerr Lener Santos da Silva Lener Santos da Silva Luciane Macedo de Souza Samir Assad de Almeida Krys Layane Guimarães Duarte Queiroz Josué Lacerda de Souza Josué Lacerda de Souza Cilana Chagas da Silva Héctor David Graterol Sequera Héctor David Graterol Sequera Mara Lúcia Gomes de Souza Mara Lúcia Gomes de Souza Anderson Nogueira Barbosa Gemilson Soares Pontes Gemilson Soares Pontes Gemilson Soares Pontes Marcus Vinitius de Farias Guerra Marcus Vinitius de Farias Guerra Rajendranath Ramasawmy Rajendranath Ramasawmy Rajendranath Ramasawmy Rajendranath Ramasawmy Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasis Frontiers in Immunology Leishmania guyanensis cytokines chemokines cutaneous leishmaniasis growth factors |
| title | Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasis |
| title_full | Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasis |
| title_fullStr | Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasis |
| title_full_unstemmed | Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasis |
| title_short | Distinct plasma chemokines and cytokines signatures in Leishmania guyanensis-infected patients with cutaneous leishmaniasis |
| title_sort | distinct plasma chemokines and cytokines signatures in leishmania guyanensis infected patients with cutaneous leishmaniasis |
| topic | Leishmania guyanensis cytokines chemokines cutaneous leishmaniasis growth factors |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.974051/full |
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