Effects of Adjuvant Chemotherapy on Insulin Resistance in Patients with Early Breast Cancer
Objective: To assess the effect of adjuvant chemotherapy on insulin resistance in patients with early breast cancer. Material and Methods: Twenty-three non-diabetic patients were included. Patients were prospectively evaluated before, during, and after chemotherapy. Demographic, anthropometric, hist...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2022-04-01
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| Series: | Cam & Sakura Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=csmedj&un=CSM-86580 |
| _version_ | 1827767273177219072 |
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| author | Izzet Doğan Yüksel Ürün Handan Onur |
| author_facet | Izzet Doğan Yüksel Ürün Handan Onur |
| author_sort | Izzet Doğan |
| collection | DOAJ |
| description | Objective: To assess the effect of adjuvant chemotherapy on insulin resistance in patients with early breast cancer.
Material and Methods: Twenty-three non-diabetic patients were included. Patients were prospectively evaluated before, during, and after chemotherapy. Demographic, anthropometric, histopathological features, and treatment data were recorded. Blood samples were taken to evaluate fasting blood glucose, fasting insulin levels, and HbA1c. Homeostatic model assessment for insulin resistance (HOMA-IR) score measured using fasting blood glucose and fasting insulin levels.
Results: Overall, pre- and post-chemotherapy mean weights were comparable (70.17 kg vs. 71.43). Prechemotherapy mean HOMA-IR was 4.99 and significantly higher than the control group of the healthy population (p=0.008). The mean values of the HOMA-IR score before, during, and after chemotherapy were 4.99, 3.47, and 3.13, respectively. Although the mean HOMA-IR decreased after chemotherapy, these decreases were not statistically significant (p=0.089). The mean fasting glucose levels before, during, and after chemotherapy were 95.5, 101.9, and 94.1 mg/dL, respectively. Before, during, and after chemotherapy, the mean fasting insulin levels were 21.43, 13.32, and 13.28 μIU/mL, respectively.
Conclusion: In the study, we observed a higher rate of insulin resistance in patients with breast cancer. The mean values of the HOMA-IR score decreased during and after chemotherapy. |
| first_indexed | 2024-03-11T11:56:27Z |
| format | Article |
| id | doaj.art-11863c170450433285b19bfee728ede7 |
| institution | Directory Open Access Journal |
| issn | 2791-8823 |
| language | English |
| last_indexed | 2024-03-11T11:56:27Z |
| publishDate | 2022-04-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Cam & Sakura Medical Journal |
| spelling | doaj.art-11863c170450433285b19bfee728ede72023-11-08T13:05:33ZengGalenos Publishing HouseCam & Sakura Medical Journal2791-88232022-04-012181310.4274/csmedj.galenos.2022.2022-1-7CSM-86580Effects of Adjuvant Chemotherapy on Insulin Resistance in Patients with Early Breast CancerIzzet Doğan0Yüksel Ürün1Handan Onur2University of Health Sciences Turkey, Başakşehir Çam and Sakura City Hospital, Clinic of Medical Oncology, Istanbul, TurkeyAnkara University Faculty of Medicine, Department of Medical Oncology, Ankara, TurkeyAnkara University Faculty of Medicine, Department of Medical Oncology, Ankara, TurkeyObjective: To assess the effect of adjuvant chemotherapy on insulin resistance in patients with early breast cancer. Material and Methods: Twenty-three non-diabetic patients were included. Patients were prospectively evaluated before, during, and after chemotherapy. Demographic, anthropometric, histopathological features, and treatment data were recorded. Blood samples were taken to evaluate fasting blood glucose, fasting insulin levels, and HbA1c. Homeostatic model assessment for insulin resistance (HOMA-IR) score measured using fasting blood glucose and fasting insulin levels. Results: Overall, pre- and post-chemotherapy mean weights were comparable (70.17 kg vs. 71.43). Prechemotherapy mean HOMA-IR was 4.99 and significantly higher than the control group of the healthy population (p=0.008). The mean values of the HOMA-IR score before, during, and after chemotherapy were 4.99, 3.47, and 3.13, respectively. Although the mean HOMA-IR decreased after chemotherapy, these decreases were not statistically significant (p=0.089). The mean fasting glucose levels before, during, and after chemotherapy were 95.5, 101.9, and 94.1 mg/dL, respectively. Before, during, and after chemotherapy, the mean fasting insulin levels were 21.43, 13.32, and 13.28 μIU/mL, respectively. Conclusion: In the study, we observed a higher rate of insulin resistance in patients with breast cancer. The mean values of the HOMA-IR score decreased during and after chemotherapy.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=csmedj&un=CSM-86580breast cancerchemotherapyhoma-irinsulin resistance |
| spellingShingle | Izzet Doğan Yüksel Ürün Handan Onur Effects of Adjuvant Chemotherapy on Insulin Resistance in Patients with Early Breast Cancer Cam & Sakura Medical Journal breast cancer chemotherapy homa-ir insulin resistance |
| title | Effects of Adjuvant Chemotherapy on Insulin Resistance in Patients with Early Breast Cancer |
| title_full | Effects of Adjuvant Chemotherapy on Insulin Resistance in Patients with Early Breast Cancer |
| title_fullStr | Effects of Adjuvant Chemotherapy on Insulin Resistance in Patients with Early Breast Cancer |
| title_full_unstemmed | Effects of Adjuvant Chemotherapy on Insulin Resistance in Patients with Early Breast Cancer |
| title_short | Effects of Adjuvant Chemotherapy on Insulin Resistance in Patients with Early Breast Cancer |
| title_sort | effects of adjuvant chemotherapy on insulin resistance in patients with early breast cancer |
| topic | breast cancer chemotherapy homa-ir insulin resistance |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=csmedj&un=CSM-86580 |
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