Polymyxin-induced neuromuscular weakness: a case report
Polymyxin-induced neuromuscular blockade is a rare but potentially fatal condition, with majority of cases that were reported between 1962 and 1973. We describe a patient who developed hypercapnic respiratory failure after initiation of polymyxin for multi-drug resistant Escherichia Coli bacteremia,...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1342419/full |
| _version_ | 1797242863914844160 |
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| author | Amanda X. Y. Chin Amanda X. Y. Chin Kay W. P. Ng Kay W. P. Ng Yee Cheun Chan Yee Cheun Chan Yihui Goh Yihui Goh Rahul Rathakrishnan |
| author_facet | Amanda X. Y. Chin Amanda X. Y. Chin Kay W. P. Ng Kay W. P. Ng Yee Cheun Chan Yee Cheun Chan Yihui Goh Yihui Goh Rahul Rathakrishnan |
| author_sort | Amanda X. Y. Chin |
| collection | DOAJ |
| description | Polymyxin-induced neuromuscular blockade is a rare but potentially fatal condition, with majority of cases that were reported between 1962 and 1973. We describe a patient who developed hypercapnic respiratory failure after initiation of polymyxin for multi-drug resistant Escherichia Coli bacteremia, due to polymyxin-induced neuromuscular dysfunction. After cessation of polymyxin, he regained full strength, had complete resolution of ptosis, and was successfully extubated. In light of the renewed use of polymyxin in this era of antimicrobial-resistance, this case aims to raise awareness about this rare but life-threatening condition, which is easily reversible with early recognition and prompt discontinuation of the drug. |
| first_indexed | 2024-04-24T18:45:59Z |
| format | Article |
| id | doaj.art-1188e3fd80e749a2ad2def2c5cd57e67 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-24T18:45:59Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-1188e3fd80e749a2ad2def2c5cd57e672024-03-27T05:11:01ZengFrontiers Media S.A.Frontiers in Neurology1664-22952024-03-011510.3389/fneur.2024.13424191342419Polymyxin-induced neuromuscular weakness: a case reportAmanda X. Y. Chin0Amanda X. Y. Chin1Kay W. P. Ng2Kay W. P. Ng3Yee Cheun Chan4Yee Cheun Chan5Yihui Goh6Yihui Goh7Rahul Rathakrishnan8Division of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, SingaporeDivision of Neurology, Department of Medicine, National University Hospital, Singapore, SingaporePolymyxin-induced neuromuscular blockade is a rare but potentially fatal condition, with majority of cases that were reported between 1962 and 1973. We describe a patient who developed hypercapnic respiratory failure after initiation of polymyxin for multi-drug resistant Escherichia Coli bacteremia, due to polymyxin-induced neuromuscular dysfunction. After cessation of polymyxin, he regained full strength, had complete resolution of ptosis, and was successfully extubated. In light of the renewed use of polymyxin in this era of antimicrobial-resistance, this case aims to raise awareness about this rare but life-threatening condition, which is easily reversible with early recognition and prompt discontinuation of the drug.https://www.frontiersin.org/articles/10.3389/fneur.2024.1342419/fullpolymyxinneuromuscular blockadeneurotoxicityrespiratory failuremulti-drug resistancerenal impairment |
| spellingShingle | Amanda X. Y. Chin Amanda X. Y. Chin Kay W. P. Ng Kay W. P. Ng Yee Cheun Chan Yee Cheun Chan Yihui Goh Yihui Goh Rahul Rathakrishnan Polymyxin-induced neuromuscular weakness: a case report Frontiers in Neurology polymyxin neuromuscular blockade neurotoxicity respiratory failure multi-drug resistance renal impairment |
| title | Polymyxin-induced neuromuscular weakness: a case report |
| title_full | Polymyxin-induced neuromuscular weakness: a case report |
| title_fullStr | Polymyxin-induced neuromuscular weakness: a case report |
| title_full_unstemmed | Polymyxin-induced neuromuscular weakness: a case report |
| title_short | Polymyxin-induced neuromuscular weakness: a case report |
| title_sort | polymyxin induced neuromuscular weakness a case report |
| topic | polymyxin neuromuscular blockade neurotoxicity respiratory failure multi-drug resistance renal impairment |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1342419/full |
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