Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer

Abstract Background The mean platelet volume/platelet count ratio (MPV/PC) ratio based on the preoperative peripheral MPV and PCcan be used to predict the prognosis of multiple malignant tumors. Objective To evaluate the prognostic value of MPV/PC in cervical cancer patients. Methods This study enro...

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Main Authors: Qicheng Deng, Qifang Long, Yanan Liu, Zhujuan Yang, Yibei Du, Xin Chen
Format: Article
Language:English
Published: BMC 2021-11-01
Series:BMC Cancer
Subjects:
Online Access:https://doi.org/10.1186/s12885-021-09016-8
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author Qicheng Deng
Qifang Long
Yanan Liu
Zhujuan Yang
Yibei Du
Xin Chen
author_facet Qicheng Deng
Qifang Long
Yanan Liu
Zhujuan Yang
Yibei Du
Xin Chen
author_sort Qicheng Deng
collection DOAJ
description Abstract Background The mean platelet volume/platelet count ratio (MPV/PC) ratio based on the preoperative peripheral MPV and PCcan be used to predict the prognosis of multiple malignant tumors. Objective To evaluate the prognostic value of MPV/PC in cervical cancer patients. Methods This study enrolled 408 patients who had undergone radical surgery for cervical cancer and evaluated the correlation of MPV/PC with patient prognosis in the primary cohort and validation cohort. Additionally, independent prognostic factors were incorporated to construct the prognostic nomogram, and the area under the receiver operating characteristic (ROC) curve (AUC) value was calculated to analyze the prognostic predictive ability of the nomogram. Results In the primary cohort, Kaplan–Meier survival analysis indicated that the overall survival (OS) for patients with MPV/PC ≤ 0.41 was significantly lower than that in patients with MPV/PC > 0.41. MPV/PC was an independent prognostic factor for resectable cervical cancer patients. Compared with neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) or monocyte/lymphocyte ratio (MLR), the AUC values of MPV/PC in predicting the 3- and 5-year survival rates for cervical cancer patients were greater. Similar results were verified in the validation cohort. Subsequently, the nomogram constructed based on MPV/PC, International Federation of Gynecology and Obstetrics (FIGO) classification and lymphovascular invasion performed well to accurately predict the prognosis of cervical cancer patients. The 3- and 5-year survival rates predicted by the nomogram were highly consistent with the real observations. Similar results were also displayed in the validation cohort. Conclusions MPV/PC may be used as a novel independent prognostic factor for patients with resectable cervical cancer. Compared with the FIGO classification system, the nomogram integrating MPV/PC maybe reliably predict the survival of cervical cancer patients after radical surgery.
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spelling doaj.art-118907d84a4c455c86958492ecc1b4102022-12-21T23:10:03ZengBMCBMC Cancer1471-24072021-11-0121111010.1186/s12885-021-09016-8Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancerQicheng Deng0Qifang Long1Yanan Liu2Zhujuan Yang3Yibei Du4Xin Chen5Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityAbstract Background The mean platelet volume/platelet count ratio (MPV/PC) ratio based on the preoperative peripheral MPV and PCcan be used to predict the prognosis of multiple malignant tumors. Objective To evaluate the prognostic value of MPV/PC in cervical cancer patients. Methods This study enrolled 408 patients who had undergone radical surgery for cervical cancer and evaluated the correlation of MPV/PC with patient prognosis in the primary cohort and validation cohort. Additionally, independent prognostic factors were incorporated to construct the prognostic nomogram, and the area under the receiver operating characteristic (ROC) curve (AUC) value was calculated to analyze the prognostic predictive ability of the nomogram. Results In the primary cohort, Kaplan–Meier survival analysis indicated that the overall survival (OS) for patients with MPV/PC ≤ 0.41 was significantly lower than that in patients with MPV/PC > 0.41. MPV/PC was an independent prognostic factor for resectable cervical cancer patients. Compared with neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) or monocyte/lymphocyte ratio (MLR), the AUC values of MPV/PC in predicting the 3- and 5-year survival rates for cervical cancer patients were greater. Similar results were verified in the validation cohort. Subsequently, the nomogram constructed based on MPV/PC, International Federation of Gynecology and Obstetrics (FIGO) classification and lymphovascular invasion performed well to accurately predict the prognosis of cervical cancer patients. The 3- and 5-year survival rates predicted by the nomogram were highly consistent with the real observations. Similar results were also displayed in the validation cohort. Conclusions MPV/PC may be used as a novel independent prognostic factor for patients with resectable cervical cancer. Compared with the FIGO classification system, the nomogram integrating MPV/PC maybe reliably predict the survival of cervical cancer patients after radical surgery.https://doi.org/10.1186/s12885-021-09016-8MPV/PCCervical cancerPrognosisNomogram
spellingShingle Qicheng Deng
Qifang Long
Yanan Liu
Zhujuan Yang
Yibei Du
Xin Chen
Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer
BMC Cancer
MPV/PC
Cervical cancer
Prognosis
Nomogram
title Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer
title_full Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer
title_fullStr Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer
title_full_unstemmed Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer
title_short Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer
title_sort prognostic value of preoperative peripheral blood mean platelet volume platelet count ratio mpv pc in patients with resectable cervical cancer
topic MPV/PC
Cervical cancer
Prognosis
Nomogram
url https://doi.org/10.1186/s12885-021-09016-8
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