Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer
Abstract Background The mean platelet volume/platelet count ratio (MPV/PC) ratio based on the preoperative peripheral MPV and PCcan be used to predict the prognosis of multiple malignant tumors. Objective To evaluate the prognostic value of MPV/PC in cervical cancer patients. Methods This study enro...
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BMC
2021-11-01
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Online Access: | https://doi.org/10.1186/s12885-021-09016-8 |
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author | Qicheng Deng Qifang Long Yanan Liu Zhujuan Yang Yibei Du Xin Chen |
author_facet | Qicheng Deng Qifang Long Yanan Liu Zhujuan Yang Yibei Du Xin Chen |
author_sort | Qicheng Deng |
collection | DOAJ |
description | Abstract Background The mean platelet volume/platelet count ratio (MPV/PC) ratio based on the preoperative peripheral MPV and PCcan be used to predict the prognosis of multiple malignant tumors. Objective To evaluate the prognostic value of MPV/PC in cervical cancer patients. Methods This study enrolled 408 patients who had undergone radical surgery for cervical cancer and evaluated the correlation of MPV/PC with patient prognosis in the primary cohort and validation cohort. Additionally, independent prognostic factors were incorporated to construct the prognostic nomogram, and the area under the receiver operating characteristic (ROC) curve (AUC) value was calculated to analyze the prognostic predictive ability of the nomogram. Results In the primary cohort, Kaplan–Meier survival analysis indicated that the overall survival (OS) for patients with MPV/PC ≤ 0.41 was significantly lower than that in patients with MPV/PC > 0.41. MPV/PC was an independent prognostic factor for resectable cervical cancer patients. Compared with neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) or monocyte/lymphocyte ratio (MLR), the AUC values of MPV/PC in predicting the 3- and 5-year survival rates for cervical cancer patients were greater. Similar results were verified in the validation cohort. Subsequently, the nomogram constructed based on MPV/PC, International Federation of Gynecology and Obstetrics (FIGO) classification and lymphovascular invasion performed well to accurately predict the prognosis of cervical cancer patients. The 3- and 5-year survival rates predicted by the nomogram were highly consistent with the real observations. Similar results were also displayed in the validation cohort. Conclusions MPV/PC may be used as a novel independent prognostic factor for patients with resectable cervical cancer. Compared with the FIGO classification system, the nomogram integrating MPV/PC maybe reliably predict the survival of cervical cancer patients after radical surgery. |
first_indexed | 2024-12-14T08:11:27Z |
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language | English |
last_indexed | 2024-12-14T08:11:27Z |
publishDate | 2021-11-01 |
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series | BMC Cancer |
spelling | doaj.art-118907d84a4c455c86958492ecc1b4102022-12-21T23:10:03ZengBMCBMC Cancer1471-24072021-11-0121111010.1186/s12885-021-09016-8Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancerQicheng Deng0Qifang Long1Yanan Liu2Zhujuan Yang3Yibei Du4Xin Chen5Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Soochow UniversityAbstract Background The mean platelet volume/platelet count ratio (MPV/PC) ratio based on the preoperative peripheral MPV and PCcan be used to predict the prognosis of multiple malignant tumors. Objective To evaluate the prognostic value of MPV/PC in cervical cancer patients. Methods This study enrolled 408 patients who had undergone radical surgery for cervical cancer and evaluated the correlation of MPV/PC with patient prognosis in the primary cohort and validation cohort. Additionally, independent prognostic factors were incorporated to construct the prognostic nomogram, and the area under the receiver operating characteristic (ROC) curve (AUC) value was calculated to analyze the prognostic predictive ability of the nomogram. Results In the primary cohort, Kaplan–Meier survival analysis indicated that the overall survival (OS) for patients with MPV/PC ≤ 0.41 was significantly lower than that in patients with MPV/PC > 0.41. MPV/PC was an independent prognostic factor for resectable cervical cancer patients. Compared with neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) or monocyte/lymphocyte ratio (MLR), the AUC values of MPV/PC in predicting the 3- and 5-year survival rates for cervical cancer patients were greater. Similar results were verified in the validation cohort. Subsequently, the nomogram constructed based on MPV/PC, International Federation of Gynecology and Obstetrics (FIGO) classification and lymphovascular invasion performed well to accurately predict the prognosis of cervical cancer patients. The 3- and 5-year survival rates predicted by the nomogram were highly consistent with the real observations. Similar results were also displayed in the validation cohort. Conclusions MPV/PC may be used as a novel independent prognostic factor for patients with resectable cervical cancer. Compared with the FIGO classification system, the nomogram integrating MPV/PC maybe reliably predict the survival of cervical cancer patients after radical surgery.https://doi.org/10.1186/s12885-021-09016-8MPV/PCCervical cancerPrognosisNomogram |
spellingShingle | Qicheng Deng Qifang Long Yanan Liu Zhujuan Yang Yibei Du Xin Chen Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer BMC Cancer MPV/PC Cervical cancer Prognosis Nomogram |
title | Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer |
title_full | Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer |
title_fullStr | Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer |
title_full_unstemmed | Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer |
title_short | Prognostic value of preoperative peripheral blood mean platelet volume/platelet count ratio (MPV/PC) in patients with resectable cervical cancer |
title_sort | prognostic value of preoperative peripheral blood mean platelet volume platelet count ratio mpv pc in patients with resectable cervical cancer |
topic | MPV/PC Cervical cancer Prognosis Nomogram |
url | https://doi.org/10.1186/s12885-021-09016-8 |
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