Iron deficiency in hepatocellular carcinoma cells induced sorafenib resistance by upregulating HIF-1α to inhibit apoptosis

Iron deficiency in hepatocellular carcinoma cells induced sorafenib resistance by upregulating HIF-1α to inhibit apoptosis

Sorafenib is the first-line therapeutic agent for hepatocellular carcinoma (HCC), but the drug resistance has become a major impediment. Previously we found that the abnormal iron metabolism in HCC led to iron deficiency, whether it induces sorafenib resistance during the treatment of HCC is not yet...

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Bibliographic Details
Main Authors: Zelong Gao, Dongyao Wang, Jianxin Yang, Min Li, Changquan Ling, Diya Lv, Yan Cao, Zhenyu Chen, Ce Shi, Hui Shen, Yuxiao Tang
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Iron deficiency
HCC
Sorafenib resistance
Apoptosis
HIF-1α
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223005395

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