The Non-Coding RNA Landscape of Plasma Cell Dyscrasias
Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat. The discovery and subsequent characterization of non-coding transcripts, which include several members with diverse length and mode of acti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/2/320 |
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| author | Eugenio Morelli Annamaria Gullà Roberta Rocca Cinzia Federico Lavinia Raimondi Stefano Malvestiti Valter Agosti Marco Rossi Giosuè Costa Gianluca Giavaresi Abdel Kareem Azab Antonia Cagnetta Michele Cea Pierosandro Tagliaferri Antonino Neri Nikhil C. Munshi Giuseppe Viglietto Pierfrancesco Tassone Nicola Amodio |
| author_facet | Eugenio Morelli Annamaria Gullà Roberta Rocca Cinzia Federico Lavinia Raimondi Stefano Malvestiti Valter Agosti Marco Rossi Giosuè Costa Gianluca Giavaresi Abdel Kareem Azab Antonia Cagnetta Michele Cea Pierosandro Tagliaferri Antonino Neri Nikhil C. Munshi Giuseppe Viglietto Pierfrancesco Tassone Nicola Amodio |
| author_sort | Eugenio Morelli |
| collection | DOAJ |
| description | Despite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat. The discovery and subsequent characterization of non-coding transcripts, which include several members with diverse length and mode of action, has unraveled novel mechanisms of gene expression regulation often malfunctioning in cancer. Increasing evidence indicates that such non-coding molecules also feature in the pathobiology of PC dyscrasias, where they are endowed with strong therapeutic and/or prognostic potential. In this review, we aim to summarize the most relevant findings on the biological and clinical features of the non-coding RNA landscape of malignant PCs, with major focus on multiple myeloma. The most relevant classes of non-coding RNAs will be examined, along with the mechanisms accounting for their dysregulation and the recent strategies used for their targeting in PC dyscrasias. It is hoped these insights may lead to clinical applications of non-coding RNA molecules as biomarkers or therapeutic targets/agents in the near future. |
| first_indexed | 2024-03-12T20:03:27Z |
| format | Article |
| id | doaj.art-118afff3c4794c35b8c90a74376c383f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T20:03:27Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-118afff3c4794c35b8c90a74376c383f2023-08-02T02:14:32ZengMDPI AGCancers2072-66942020-01-0112232010.3390/cancers12020320cancers12020320The Non-Coding RNA Landscape of Plasma Cell DyscrasiasEugenio Morelli0Annamaria Gullà1Roberta Rocca2Cinzia Federico3Lavinia Raimondi4Stefano Malvestiti5Valter Agosti6Marco Rossi7Giosuè Costa8Gianluca Giavaresi9Abdel Kareem Azab10Antonia Cagnetta11Michele Cea12Pierosandro Tagliaferri13Antonino Neri14Nikhil C. Munshi15Giuseppe Viglietto16Pierfrancesco Tassone17Nicola Amodio18Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USADana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USADepartment of Experimental and Clinical Medicine, <i>Magna Graecia</i> University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Radiation Oncology, Cancer Biology Division, Washington University in St. Louis School of Medicine, St. Louis, MO 63108, USAIRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USADepartment of Experimental and Clinical Medicine, <i>Magna Graecia</i> University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, <i>Magna Graecia</i> University of Catanzaro, 88100 Catanzaro, ItalyNet4Science srl, <i>Magna Graecia</i> University of Catanzaro, 88100 Catanzaro, ItalyIRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, ItalyDepartment of Radiation Oncology, Cancer Biology Division, Washington University in St. Louis School of Medicine, St. Louis, MO 63108, USAIRCCS, Ospedale Policlinico San Martino, 16100 Genoa, ItalyIRCCS, Ospedale Policlinico San Martino, 16100 Genoa, ItalyDepartment of Experimental and Clinical Medicine, <i>Magna Graecia</i> University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Oncology and Hemato-oncology, University of Milan and Hematology, Fondazione Cà Granda IRCCS Policlinico, 20122 Milan, ItalyDana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USADepartment of Experimental and Clinical Medicine, <i>Magna Graecia</i> University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, <i>Magna Graecia</i> University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, <i>Magna Graecia</i> University of Catanzaro, 88100 Catanzaro, ItalyDespite substantial advancements have been done in the understanding of the pathogenesis of plasma cell (PC) disorders, these malignancies remain hard-to-treat. The discovery and subsequent characterization of non-coding transcripts, which include several members with diverse length and mode of action, has unraveled novel mechanisms of gene expression regulation often malfunctioning in cancer. Increasing evidence indicates that such non-coding molecules also feature in the pathobiology of PC dyscrasias, where they are endowed with strong therapeutic and/or prognostic potential. In this review, we aim to summarize the most relevant findings on the biological and clinical features of the non-coding RNA landscape of malignant PCs, with major focus on multiple myeloma. The most relevant classes of non-coding RNAs will be examined, along with the mechanisms accounting for their dysregulation and the recent strategies used for their targeting in PC dyscrasias. It is hoped these insights may lead to clinical applications of non-coding RNA molecules as biomarkers or therapeutic targets/agents in the near future.https://www.mdpi.com/2072-6694/12/2/320multiple myelomanon-coding rnaplasma cell dyscrasiamirnalncrna |
| spellingShingle | Eugenio Morelli Annamaria Gullà Roberta Rocca Cinzia Federico Lavinia Raimondi Stefano Malvestiti Valter Agosti Marco Rossi Giosuè Costa Gianluca Giavaresi Abdel Kareem Azab Antonia Cagnetta Michele Cea Pierosandro Tagliaferri Antonino Neri Nikhil C. Munshi Giuseppe Viglietto Pierfrancesco Tassone Nicola Amodio The Non-Coding RNA Landscape of Plasma Cell Dyscrasias Cancers multiple myeloma non-coding rna plasma cell dyscrasia mirna lncrna |
| title | The Non-Coding RNA Landscape of Plasma Cell Dyscrasias |
| title_full | The Non-Coding RNA Landscape of Plasma Cell Dyscrasias |
| title_fullStr | The Non-Coding RNA Landscape of Plasma Cell Dyscrasias |
| title_full_unstemmed | The Non-Coding RNA Landscape of Plasma Cell Dyscrasias |
| title_short | The Non-Coding RNA Landscape of Plasma Cell Dyscrasias |
| title_sort | non coding rna landscape of plasma cell dyscrasias |
| topic | multiple myeloma non-coding rna plasma cell dyscrasia mirna lncrna |
| url | https://www.mdpi.com/2072-6694/12/2/320 |
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