Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillation
Abstract Background Estimated glomerular filtration rate (eGFR) is a widely accepted indicator of renal function. The aim of this study was to evaluate the relationship between eGFR and 3-year clinical outcomes among Chinese patients with atrial fibrillation (AF). Methods We retrospectively studied...
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| Format: | Article |
| Language: | English |
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BMC
2020-11-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12872-020-01786-6 |
| _version_ | 1818401063271661568 |
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| author | Huaibin Wan Juan Wang Yanmin Yang Xin Fan Dongdong Chen Ning Bian |
| author_facet | Huaibin Wan Juan Wang Yanmin Yang Xin Fan Dongdong Chen Ning Bian |
| author_sort | Huaibin Wan |
| collection | DOAJ |
| description | Abstract Background Estimated glomerular filtration rate (eGFR) is a widely accepted indicator of renal function. The aim of this study was to evaluate the relationship between eGFR and 3-year clinical outcomes among Chinese patients with atrial fibrillation (AF). Methods We retrospectively studied 433 consecutive Chinese patients with AF (51.0% males, mean age 65.6 ± 13.2 years) between February 2013 and December 2017. Baseline clinical data were collected according to medical records. eGFR was calculated by MDRD equation for Chinese patients according to baseline age, sex and serum creatinine. The primary clinical outcome of interest was all-cause mortality. Results During a median follow-up period of 3.1 (0.5–4.5) years, 73 deaths (16.9%) were recorded. Multivariate Cox regression analyses indicated that eGFR was independently associated with all-cause death in total population [hazard ratio (HR) 0.984; 95% confidence interval (CI) 0.972–0.995, P = 0.006] and patients free of valvular heart diseases (VHDs) (HR 0.975; 95% CI 0.959–0.992, P = 0.003), but not with VHDs. A receiver operating characteristic (ROC) analysis revealed that reduced eGFR predicted all-cause mortality with areas under the ROC curve of 0.637 (95% CI 0.539–0.735, P = 0.004) in AF patients free of VHDs. Conclusions eGFR is an independent predictor of 3-year all-cause mortality among Chinese patients with AF, especially among those patients free of VHDs. |
| first_indexed | 2024-12-14T07:46:30Z |
| format | Article |
| id | doaj.art-118b818cd1b34d5aab561d468a671643 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-14T07:46:30Z |
| publishDate | 2020-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-118b818cd1b34d5aab561d468a6716432022-12-21T23:10:53ZengBMCBMC Cardiovascular Disorders1471-22612020-11-0120111010.1186/s12872-020-01786-6Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillationHuaibin Wan0Juan Wang1Yanmin Yang2Xin Fan3Dongdong Chen4Ning Bian5Department of Cardiology, Dongguan People’s Hospital, Southern Medical UniversityEmergency and Intensive Care Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeEmergency and Intensive Care Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Cardiology, Dongguan People’s Hospital, Southern Medical UniversityDepartment of Cardiology, First Affiliated Hospital, Jinan UniversityDepartment of Cardiology, First Affiliated Hospital, Jinan UniversityAbstract Background Estimated glomerular filtration rate (eGFR) is a widely accepted indicator of renal function. The aim of this study was to evaluate the relationship between eGFR and 3-year clinical outcomes among Chinese patients with atrial fibrillation (AF). Methods We retrospectively studied 433 consecutive Chinese patients with AF (51.0% males, mean age 65.6 ± 13.2 years) between February 2013 and December 2017. Baseline clinical data were collected according to medical records. eGFR was calculated by MDRD equation for Chinese patients according to baseline age, sex and serum creatinine. The primary clinical outcome of interest was all-cause mortality. Results During a median follow-up period of 3.1 (0.5–4.5) years, 73 deaths (16.9%) were recorded. Multivariate Cox regression analyses indicated that eGFR was independently associated with all-cause death in total population [hazard ratio (HR) 0.984; 95% confidence interval (CI) 0.972–0.995, P = 0.006] and patients free of valvular heart diseases (VHDs) (HR 0.975; 95% CI 0.959–0.992, P = 0.003), but not with VHDs. A receiver operating characteristic (ROC) analysis revealed that reduced eGFR predicted all-cause mortality with areas under the ROC curve of 0.637 (95% CI 0.539–0.735, P = 0.004) in AF patients free of VHDs. Conclusions eGFR is an independent predictor of 3-year all-cause mortality among Chinese patients with AF, especially among those patients free of VHDs.http://link.springer.com/article/10.1186/s12872-020-01786-6Estimated glomerular filtration rateAtrial fibrillationSurvival |
| spellingShingle | Huaibin Wan Juan Wang Yanmin Yang Xin Fan Dongdong Chen Ning Bian Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillation BMC Cardiovascular Disorders Estimated glomerular filtration rate Atrial fibrillation Survival |
| title | Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillation |
| title_full | Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillation |
| title_fullStr | Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillation |
| title_full_unstemmed | Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillation |
| title_short | Impact of estimated glomerular filtration rate on long-term clinical outcomes among Chinese patients with atrial fibrillation |
| title_sort | impact of estimated glomerular filtration rate on long term clinical outcomes among chinese patients with atrial fibrillation |
| topic | Estimated glomerular filtration rate Atrial fibrillation Survival |
| url | http://link.springer.com/article/10.1186/s12872-020-01786-6 |
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