The impact of smoking on adjuvant breast cancer radiation treatment: A systematic review
Background: The influence of cigarette smoking on cancer risk has been well-studied. Similarly, exposure to ionizing radiation from radiotherapy (RT) can produce detrimental effects on an individual's health. In patients administered RT, there has been an observed relationship in other primary...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294220300228 |
| _version_ | 1831641495408476160 |
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| author | Gina Wong Emily Lam Irene Karam Caitlin Yee Leah Drost Samantha Tam Henry Lam Alyson McCarvell Erin McKenzie Edward Chow |
| author_facet | Gina Wong Emily Lam Irene Karam Caitlin Yee Leah Drost Samantha Tam Henry Lam Alyson McCarvell Erin McKenzie Edward Chow |
| author_sort | Gina Wong |
| collection | DOAJ |
| description | Background: The influence of cigarette smoking on cancer risk has been well-studied. Similarly, exposure to ionizing radiation from radiotherapy (RT) can produce detrimental effects on an individual's health. In patients administered RT, there has been an observed relationship in other primary carcinomas. The purpose of this systematic review was to summarize the influence of cigarette smoking on outcomes post adjuvant RT in breast cancer patients. Methods: OVID Medline, Cochrane and Embase were searched and 1893 articles were identified. A total of 71 articles were included in the review. Study type, published year and sample size, age, systemic therapies, RT techniques and treatment side effects were collected if available. Results: The review found 198 different outcomes which fell into 7 categories and similar outcomes were recorded. 40% of skin reaction outcomes, 50% of cardiovascular outcomes, 71% of reconstruction outcomes, 29% of pulmonary function outcomes, 33% of mortality outcomes and 42% of secondary recurrence outcomes reported significant differences between smokers and non-smokers. None of the articles reported non-smokers to have a higher risk than smokers. Conclusion: Cigarette smoking can pose a higher risk of post-treatment complications that can influence an individual's quality of life, survival rate and/or recurrence risk. This review further assessed the impact of smoking on various patient outcomes and side-effects in the adjuvant breast RT setting. The information provided in this review suggest that smoking cessation programs would help educate patients to understand their risks of being a current or former smoker when undergoing RT. |
| first_indexed | 2024-12-19T12:25:08Z |
| format | Article |
| id | doaj.art-118c0a807796459ab94ca6485a89396d |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-12-19T12:25:08Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-118c0a807796459ab94ca6485a89396d2022-12-21T20:21:34ZengElsevierCancer Treatment and Research Communications2468-29422020-01-0124100185The impact of smoking on adjuvant breast cancer radiation treatment: A systematic reviewGina Wong0Emily Lam1Irene Karam2Caitlin Yee3Leah Drost4Samantha Tam5Henry Lam6Alyson McCarvell7Erin McKenzie8Edward Chow9Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaOdette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaCorresponding author.; Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaBackground: The influence of cigarette smoking on cancer risk has been well-studied. Similarly, exposure to ionizing radiation from radiotherapy (RT) can produce detrimental effects on an individual's health. In patients administered RT, there has been an observed relationship in other primary carcinomas. The purpose of this systematic review was to summarize the influence of cigarette smoking on outcomes post adjuvant RT in breast cancer patients. Methods: OVID Medline, Cochrane and Embase were searched and 1893 articles were identified. A total of 71 articles were included in the review. Study type, published year and sample size, age, systemic therapies, RT techniques and treatment side effects were collected if available. Results: The review found 198 different outcomes which fell into 7 categories and similar outcomes were recorded. 40% of skin reaction outcomes, 50% of cardiovascular outcomes, 71% of reconstruction outcomes, 29% of pulmonary function outcomes, 33% of mortality outcomes and 42% of secondary recurrence outcomes reported significant differences between smokers and non-smokers. None of the articles reported non-smokers to have a higher risk than smokers. Conclusion: Cigarette smoking can pose a higher risk of post-treatment complications that can influence an individual's quality of life, survival rate and/or recurrence risk. This review further assessed the impact of smoking on various patient outcomes and side-effects in the adjuvant breast RT setting. The information provided in this review suggest that smoking cessation programs would help educate patients to understand their risks of being a current or former smoker when undergoing RT.http://www.sciencedirect.com/science/article/pii/S2468294220300228SmokingBreast cancerRadiotherapyAdverse effects |
| spellingShingle | Gina Wong Emily Lam Irene Karam Caitlin Yee Leah Drost Samantha Tam Henry Lam Alyson McCarvell Erin McKenzie Edward Chow The impact of smoking on adjuvant breast cancer radiation treatment: A systematic review Cancer Treatment and Research Communications Smoking Breast cancer Radiotherapy Adverse effects |
| title | The impact of smoking on adjuvant breast cancer radiation treatment: A systematic review |
| title_full | The impact of smoking on adjuvant breast cancer radiation treatment: A systematic review |
| title_fullStr | The impact of smoking on adjuvant breast cancer radiation treatment: A systematic review |
| title_full_unstemmed | The impact of smoking on adjuvant breast cancer radiation treatment: A systematic review |
| title_short | The impact of smoking on adjuvant breast cancer radiation treatment: A systematic review |
| title_sort | impact of smoking on adjuvant breast cancer radiation treatment a systematic review |
| topic | Smoking Breast cancer Radiotherapy Adverse effects |
| url | http://www.sciencedirect.com/science/article/pii/S2468294220300228 |
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