A randomized double-blinded comparison between dexmedetomidine and clonidine as an adjuvant to caudal ropivacaine in children for below umbilical surgery
Background: Alpha-2 adenoreceptors as an adjuvant to local anesthetic during caudal analgesia in children prolongs the duration of analgesia. This study was designed to compare the analgesic efficacy and adverse effects of dexmedetomidine and clonidine when added to ropivacaine for caudal analgesia...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2017-01-01
|
| Series: | Journal of Clinical Sciences |
| Subjects: | |
| Online Access: | http://www.jcsjournal.org/article.asp?issn=2468-6859;year=2017;volume=14;issue=4;spage=157;epage=161;aulast=Mavuri |
| _version_ | 1828788335475163136 |
|---|---|
| author | Ganapathi Mavuri Priyanka Jain Swastika Chakraborty Sandeep Kumar Mucherla Ashok Jadon |
| author_facet | Ganapathi Mavuri Priyanka Jain Swastika Chakraborty Sandeep Kumar Mucherla Ashok Jadon |
| author_sort | Ganapathi Mavuri |
| collection | DOAJ |
| description | Background: Alpha-2 adenoreceptors as an adjuvant to local anesthetic during caudal analgesia in children prolongs the duration of analgesia. This study was designed to compare the analgesic efficacy and adverse effects of dexmedetomidine and clonidine when added to ropivacaine for caudal analgesia in children undergoing lower abdominal surgeries. Methods: In a prospective study, Seventy-eight children received block with either 0.2% ropivacaine 1.5 mg/kg (Group R; n = 26) or 0.2% ropivacaine 1.5 mg/kg + 1 mcg/kg clonidine (Group RC; n = 26) or 0.2% ropivacaine 1.5 mg/kg + dexmedetomidine 1 mcg/kg (Group RD; n = 26). Results: Duration of analgesia was 7.15 ± 1.00 h in Group R, 11.57 ± 1.27 h in Group R + C, and 14.73 ± 1.53 h in Group R + D (P < 0.0001). One patient in Group R + D had vomiting and 1 patient in Group R had urinary retention which was not statistically significant (P > 0.05). Conclusion: Addition of clonidine and dexmedetomidine to caudal ropivacaine significantly prolongs the duration of analgesia without adverse effects. |
| first_indexed | 2024-12-12T00:50:47Z |
| format | Article |
| id | doaj.art-118d44c7353f4683a82901ac1cc94bac |
| institution | Directory Open Access Journal |
| issn | 2468-6859 2408-7408 |
| language | English |
| last_indexed | 2024-12-12T00:50:47Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical Sciences |
| spelling | doaj.art-118d44c7353f4683a82901ac1cc94bac2022-12-22T00:44:01ZengWolters Kluwer Medknow PublicationsJournal of Clinical Sciences2468-68592408-74082017-01-0114415716110.4103/jcls.jcls_15_17A randomized double-blinded comparison between dexmedetomidine and clonidine as an adjuvant to caudal ropivacaine in children for below umbilical surgeryGanapathi MavuriPriyanka JainSwastika ChakrabortySandeep Kumar MucherlaAshok JadonBackground: Alpha-2 adenoreceptors as an adjuvant to local anesthetic during caudal analgesia in children prolongs the duration of analgesia. This study was designed to compare the analgesic efficacy and adverse effects of dexmedetomidine and clonidine when added to ropivacaine for caudal analgesia in children undergoing lower abdominal surgeries. Methods: In a prospective study, Seventy-eight children received block with either 0.2% ropivacaine 1.5 mg/kg (Group R; n = 26) or 0.2% ropivacaine 1.5 mg/kg + 1 mcg/kg clonidine (Group RC; n = 26) or 0.2% ropivacaine 1.5 mg/kg + dexmedetomidine 1 mcg/kg (Group RD; n = 26). Results: Duration of analgesia was 7.15 ± 1.00 h in Group R, 11.57 ± 1.27 h in Group R + C, and 14.73 ± 1.53 h in Group R + D (P < 0.0001). One patient in Group R + D had vomiting and 1 patient in Group R had urinary retention which was not statistically significant (P > 0.05). Conclusion: Addition of clonidine and dexmedetomidine to caudal ropivacaine significantly prolongs the duration of analgesia without adverse effects.http://www.jcsjournal.org/article.asp?issn=2468-6859;year=2017;volume=14;issue=4;spage=157;epage=161;aulast=MavuriAnalgesiacaudalclonidinedexmedetomidinefacelegactivitycry and consolability scorepostoperative periodropivacainesevoflurane |
| spellingShingle | Ganapathi Mavuri Priyanka Jain Swastika Chakraborty Sandeep Kumar Mucherla Ashok Jadon A randomized double-blinded comparison between dexmedetomidine and clonidine as an adjuvant to caudal ropivacaine in children for below umbilical surgery Journal of Clinical Sciences Analgesia caudal clonidine dexmedetomidine face leg activity cry and consolability score postoperative period ropivacaine sevoflurane |
| title | A randomized double-blinded comparison between dexmedetomidine and clonidine as an adjuvant to caudal ropivacaine in children for below umbilical surgery |
| title_full | A randomized double-blinded comparison between dexmedetomidine and clonidine as an adjuvant to caudal ropivacaine in children for below umbilical surgery |
| title_fullStr | A randomized double-blinded comparison between dexmedetomidine and clonidine as an adjuvant to caudal ropivacaine in children for below umbilical surgery |
| title_full_unstemmed | A randomized double-blinded comparison between dexmedetomidine and clonidine as an adjuvant to caudal ropivacaine in children for below umbilical surgery |
| title_short | A randomized double-blinded comparison between dexmedetomidine and clonidine as an adjuvant to caudal ropivacaine in children for below umbilical surgery |
| title_sort | randomized double blinded comparison between dexmedetomidine and clonidine as an adjuvant to caudal ropivacaine in children for below umbilical surgery |
| topic | Analgesia caudal clonidine dexmedetomidine face leg activity cry and consolability score postoperative period ropivacaine sevoflurane |
| url | http://www.jcsjournal.org/article.asp?issn=2468-6859;year=2017;volume=14;issue=4;spage=157;epage=161;aulast=Mavuri |
| work_keys_str_mv | AT ganapathimavuri arandomizeddoubleblindedcomparisonbetweendexmedetomidineandclonidineasanadjuvanttocaudalropivacaineinchildrenforbelowumbilicalsurgery AT priyankajain arandomizeddoubleblindedcomparisonbetweendexmedetomidineandclonidineasanadjuvanttocaudalropivacaineinchildrenforbelowumbilicalsurgery AT swastikachakraborty arandomizeddoubleblindedcomparisonbetweendexmedetomidineandclonidineasanadjuvanttocaudalropivacaineinchildrenforbelowumbilicalsurgery AT sandeepkumarmucherla arandomizeddoubleblindedcomparisonbetweendexmedetomidineandclonidineasanadjuvanttocaudalropivacaineinchildrenforbelowumbilicalsurgery AT ashokjadon arandomizeddoubleblindedcomparisonbetweendexmedetomidineandclonidineasanadjuvanttocaudalropivacaineinchildrenforbelowumbilicalsurgery AT ganapathimavuri randomizeddoubleblindedcomparisonbetweendexmedetomidineandclonidineasanadjuvanttocaudalropivacaineinchildrenforbelowumbilicalsurgery AT priyankajain randomizeddoubleblindedcomparisonbetweendexmedetomidineandclonidineasanadjuvanttocaudalropivacaineinchildrenforbelowumbilicalsurgery AT swastikachakraborty randomizeddoubleblindedcomparisonbetweendexmedetomidineandclonidineasanadjuvanttocaudalropivacaineinchildrenforbelowumbilicalsurgery AT sandeepkumarmucherla randomizeddoubleblindedcomparisonbetweendexmedetomidineandclonidineasanadjuvanttocaudalropivacaineinchildrenforbelowumbilicalsurgery AT ashokjadon randomizeddoubleblindedcomparisonbetweendexmedetomidineandclonidineasanadjuvanttocaudalropivacaineinchildrenforbelowumbilicalsurgery |