Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge

Development of asthmatic inflammation in mice following early-life exposure to ambient environmental particulates and chronic allergen challenge

SUMMARY Childhood exposure to environmental particulates increases the risk of development of asthma. The underlying mechanisms might include oxidant injury to airway epithelial cells (AEC). We investigated the ability of ambient environmental particulates to contribute to sensitization via the airw...

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Bibliographic Details
Main Authors: Cristan Herbert, Jessica S. Siegle, Alexander M. Shadie, Stina Nikolaysen, Linda Garthwaite, Nicole G. Hansbro, Paul S. Foster, Rakesh K. Kumar
Format: Article
Language:English
Published: The Company of Biologists 2013-03-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/6/2/479

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