Systemic photodynamic therapy with photosensitizer photolon in the treatment of cancer patients with regional and distant metastases
<p> </p><p>The results of photodynamic therapy (PDT) in 76 patients with tumors of different sites and with regional or distant metastases are represented. Sixty three patients were under combined or multimodal therapy, 13 patients had systemic PDT as monotherapy. The technique of...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2014-01-01
|
| Series: | Biomedical Photonics |
| Subjects: | |
| Online Access: | http://www.pdt-journal.com:80/jour/article/view/51 |
| _version_ | 1818957671981645824 |
|---|---|
| author | M. A. Kaplan A. M. Shubina I. A. Zamulaeva E. I. Selivanova E. G. Kuz’mina N. P. Tkachenko I. G. Zakurdyaeva V. N. Kapinus E. V. Goranskaya |
| author_facet | M. A. Kaplan A. M. Shubina I. A. Zamulaeva E. I. Selivanova E. G. Kuz’mina N. P. Tkachenko I. G. Zakurdyaeva V. N. Kapinus E. V. Goranskaya |
| author_sort | M. A. Kaplan |
| collection | DOAJ |
| description | <p> </p><p>The results of photodynamic therapy (PDT) in 76 patients with tumors of different sites and with regional or distant metastases are represented. Sixty three patients were under combined or multimodal therapy, 13 patients had systemic PDT as monotherapy. The technique of PDT was as follows: the solution of photosensitizer photolon was administered intravenously at dose of 0.8–1.4 mg/ kg body weight. Laser blood irradiation was performed simultaneously (wavelength of 662 nm, output power of 20 mW, irradiation time of 50 min). Stabilization of the disease defined as the absence of new tumor foci was observed in 55% of treated patients: among them in 47% of patients with disseminated melanoma during 6–10 months after treatment, in 65% patients with breast cancer – for 3–6 years after treatment, and also in 100% of patients with cancer of other sites (colorectal, pancreatic, cervical, ovarian, lung and stomach cancer, retroperitoneal neuroblastoma) – for 10–12 months after treatment. According to ultrasound data the shrinkage of most of metastases up to its complete disappearance was observed. The authors consider that effects of systemic PDT are due to decrease of circulating tumor cells in blood and also due to beneficial impact of this modal of treatment on immune status of cancer patient. Intravenous PDT was shown to improve treatment results and quality of life in patients with metastases of malignant tumors. The approved technique is of considerable interest and requires further investigation of its efficiency including its combination with methods of combined and multimodal treatment.</p><p> </p> |
| first_indexed | 2024-12-20T11:13:34Z |
| format | Article |
| id | doaj.art-119253f22c8f416694fe430a99f2b759 |
| institution | Directory Open Access Journal |
| issn | 2413-9432 |
| language | Russian |
| last_indexed | 2024-12-20T11:13:34Z |
| publishDate | 2014-01-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj.art-119253f22c8f416694fe430a99f2b7592022-12-21T19:42:41ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322014-01-0134182349Systemic photodynamic therapy with photosensitizer photolon in the treatment of cancer patients with regional and distant metastasesM. A. Kaplan0A. M. Shubina1I. A. Zamulaeva2E. I. Selivanova3E. G. Kuz’mina4N. P. Tkachenko5I. G. Zakurdyaeva6V. N. Kapinus7E. V. Goranskaya8Национальный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, МоскваНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, Россия<p> </p><p>The results of photodynamic therapy (PDT) in 76 patients with tumors of different sites and with regional or distant metastases are represented. Sixty three patients were under combined or multimodal therapy, 13 patients had systemic PDT as monotherapy. The technique of PDT was as follows: the solution of photosensitizer photolon was administered intravenously at dose of 0.8–1.4 mg/ kg body weight. Laser blood irradiation was performed simultaneously (wavelength of 662 nm, output power of 20 mW, irradiation time of 50 min). Stabilization of the disease defined as the absence of new tumor foci was observed in 55% of treated patients: among them in 47% of patients with disseminated melanoma during 6–10 months after treatment, in 65% patients with breast cancer – for 3–6 years after treatment, and also in 100% of patients with cancer of other sites (colorectal, pancreatic, cervical, ovarian, lung and stomach cancer, retroperitoneal neuroblastoma) – for 10–12 months after treatment. According to ultrasound data the shrinkage of most of metastases up to its complete disappearance was observed. The authors consider that effects of systemic PDT are due to decrease of circulating tumor cells in blood and also due to beneficial impact of this modal of treatment on immune status of cancer patient. Intravenous PDT was shown to improve treatment results and quality of life in patients with metastases of malignant tumors. The approved technique is of considerable interest and requires further investigation of its efficiency including its combination with methods of combined and multimodal treatment.</p><p> </p>http://www.pdt-journal.com:80/jour/article/view/51системная фотодинамическая терапияотдаленные метастазырегионарные метастазыфотолон |
| spellingShingle | M. A. Kaplan A. M. Shubina I. A. Zamulaeva E. I. Selivanova E. G. Kuz’mina N. P. Tkachenko I. G. Zakurdyaeva V. N. Kapinus E. V. Goranskaya Systemic photodynamic therapy with photosensitizer photolon in the treatment of cancer patients with regional and distant metastases Biomedical Photonics системная фотодинамическая терапия отдаленные метастазы регионарные метастазы фотолон |
| title | Systemic photodynamic therapy with photosensitizer photolon in the treatment of cancer patients with regional and distant metastases |
| title_full | Systemic photodynamic therapy with photosensitizer photolon in the treatment of cancer patients with regional and distant metastases |
| title_fullStr | Systemic photodynamic therapy with photosensitizer photolon in the treatment of cancer patients with regional and distant metastases |
| title_full_unstemmed | Systemic photodynamic therapy with photosensitizer photolon in the treatment of cancer patients with regional and distant metastases |
| title_short | Systemic photodynamic therapy with photosensitizer photolon in the treatment of cancer patients with regional and distant metastases |
| title_sort | systemic photodynamic therapy with photosensitizer photolon in the treatment of cancer patients with regional and distant metastases |
| topic | системная фотодинамическая терапия отдаленные метастазы регионарные метастазы фотолон |
| url | http://www.pdt-journal.com:80/jour/article/view/51 |
| work_keys_str_mv | AT makaplan systemicphotodynamictherapywithphotosensitizerphotoloninthetreatmentofcancerpatientswithregionalanddistantmetastases AT amshubina systemicphotodynamictherapywithphotosensitizerphotoloninthetreatmentofcancerpatientswithregionalanddistantmetastases AT iazamulaeva systemicphotodynamictherapywithphotosensitizerphotoloninthetreatmentofcancerpatientswithregionalanddistantmetastases AT eiselivanova systemicphotodynamictherapywithphotosensitizerphotoloninthetreatmentofcancerpatientswithregionalanddistantmetastases AT egkuzmina systemicphotodynamictherapywithphotosensitizerphotoloninthetreatmentofcancerpatientswithregionalanddistantmetastases AT nptkachenko systemicphotodynamictherapywithphotosensitizerphotoloninthetreatmentofcancerpatientswithregionalanddistantmetastases AT igzakurdyaeva systemicphotodynamictherapywithphotosensitizerphotoloninthetreatmentofcancerpatientswithregionalanddistantmetastases AT vnkapinus systemicphotodynamictherapywithphotosensitizerphotoloninthetreatmentofcancerpatientswithregionalanddistantmetastases AT evgoranskaya systemicphotodynamictherapywithphotosensitizerphotoloninthetreatmentofcancerpatientswithregionalanddistantmetastases |