An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal Diseases
Several investigators have reported about the intricate molecular mechanism underlying periodontal diseases (PD). Nevertheless, the role of specific genes, cells, or cellular mechanisms involved in the pathogenesis of periodontitis are still unclear. Although periodontitis is one of the most prevale...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/11/3829 |
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| author | Syed Saad B. Qasim Dalal Al-Otaibi Reham Al-Jasser Sarhang S. Gul Muhammad Sohail Zafar |
| author_facet | Syed Saad B. Qasim Dalal Al-Otaibi Reham Al-Jasser Sarhang S. Gul Muhammad Sohail Zafar |
| author_sort | Syed Saad B. Qasim |
| collection | DOAJ |
| description | Several investigators have reported about the intricate molecular mechanism underlying periodontal diseases (PD). Nevertheless, the role of specific genes, cells, or cellular mechanisms involved in the pathogenesis of periodontitis are still unclear. Although periodontitis is one of the most prevalent oral diseases globally, there are no pre-diagnostic markers or therapeutic targets available for such inflammatory lesions. A pivotal role is played by pro- and anti-inflammatory markers in modulating pathophysiological and physiological processes in repairing damaged tissues. In addition, effects on osteoimmunology is ever evolving due to the ongoing research in understanding the molecular mechanism lying beneath periodontal diseases. The aim of the current review is to deliver an evidence-based update on the molecular mechanism of periodontitis with a particular focus on recent developments. Reports regarding the molecular mechanism of these diseases have revealed unforeseen results indicative of the fact that significant advances have been made to the periodontal medicine over the past decade. There is integrated hypothesis-driven research going on. Although a wide picture of association of periodontal diseases with immune response has been further clarified with present ongoing research, small parts of the puzzle remain a mystery and require further investigations. |
| first_indexed | 2024-03-10T19:32:22Z |
| format | Article |
| id | doaj.art-11934d3744714eb097d45cf2494c389f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T19:32:22Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-11934d3744714eb097d45cf2494c389f2023-11-20T02:00:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-012111382910.3390/ijms21113829An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal DiseasesSyed Saad B. Qasim0Dalal Al-Otaibi1Reham Al-Jasser2Sarhang S. Gul3Muhammad Sohail Zafar4Department of Bioclincial Sciences, Faculty of Dentistry, Kuwait University, Safat 24923, KuwaitDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 60169, Saudi ArabiaDepartment of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh 60169, Saudi ArabiaCollege of Dentistry, Periodontics Department, University of Sulaimani, Sulaymaniyah 1124-30, IraqDepartment of Restorative Dentistry, College of Dentistry, Taibah University, Al-Madina Al-Munawwarah 41311, Saudi ArabiaSeveral investigators have reported about the intricate molecular mechanism underlying periodontal diseases (PD). Nevertheless, the role of specific genes, cells, or cellular mechanisms involved in the pathogenesis of periodontitis are still unclear. Although periodontitis is one of the most prevalent oral diseases globally, there are no pre-diagnostic markers or therapeutic targets available for such inflammatory lesions. A pivotal role is played by pro- and anti-inflammatory markers in modulating pathophysiological and physiological processes in repairing damaged tissues. In addition, effects on osteoimmunology is ever evolving due to the ongoing research in understanding the molecular mechanism lying beneath periodontal diseases. The aim of the current review is to deliver an evidence-based update on the molecular mechanism of periodontitis with a particular focus on recent developments. Reports regarding the molecular mechanism of these diseases have revealed unforeseen results indicative of the fact that significant advances have been made to the periodontal medicine over the past decade. There is integrated hypothesis-driven research going on. Although a wide picture of association of periodontal diseases with immune response has been further clarified with present ongoing research, small parts of the puzzle remain a mystery and require further investigations.https://www.mdpi.com/1422-0067/21/11/3829periodontitismolecular mechanisminflammationgeneticsproteomicsmetabolomics |
| spellingShingle | Syed Saad B. Qasim Dalal Al-Otaibi Reham Al-Jasser Sarhang S. Gul Muhammad Sohail Zafar An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal Diseases International Journal of Molecular Sciences periodontitis molecular mechanism inflammation genetics proteomics metabolomics |
| title | An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal Diseases |
| title_full | An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal Diseases |
| title_fullStr | An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal Diseases |
| title_full_unstemmed | An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal Diseases |
| title_short | An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal Diseases |
| title_sort | evidence based update on the molecular mechanisms underlying periodontal diseases |
| topic | periodontitis molecular mechanism inflammation genetics proteomics metabolomics |
| url | https://www.mdpi.com/1422-0067/21/11/3829 |
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