Evidentiation of Paramyosin (Sm-97) as a Modulating Antigen on Granulomatous Hypersensitivity to Schistosoma mansoni Eggs
A Schistosoma mansoni adult worm anionic fraction (PIII) has previously been shown to protect mice against challenge infection and to reduce pulmonary and hepatic granulomatous hypersensitivity. Serum from PIII-immunized rabbit was used to screen a lgt11 cDNA library from S. mansoni adult worm in or...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1997-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000500020 |
| _version_ | 1797703086643347456 |
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| author | Hirsch Cristine Carvalho-Queiroz Claudia Franco Gloria R Pena Sergio DJ Simpson Andrew JG Goes Alfredo M |
| author_facet | Hirsch Cristine Carvalho-Queiroz Claudia Franco Gloria R Pena Sergio DJ Simpson Andrew JG Goes Alfredo M |
| author_sort | Hirsch Cristine |
| collection | DOAJ |
| description | A Schistosoma mansoni adult worm anionic fraction (PIII) has previously been shown to protect mice against challenge infection and to reduce pulmonary and hepatic granulomatous hypersensitivity. Serum from PIII-immunized rabbit was used to screen a lgt11 cDNA library from S. mansoni adult worm in order to identify antigens capable of modulating granulomatous hypersensitivity. We obtained four clones with 400 (Sm-III.11), 900 (Sm-III.16), 1100 (Sm-III.10) and 1300 (Sm-III.12) bp of length. All clone-specific antibodies were able to recognize most of the PIII components. The sequence analysis showed that these clones presented high homology with S. mansoni paramyosin (Sm-97). These findings ascribe a new function to this antigen with an important role in modulation of granulomatous hypersensitivity to S. mansoni eggs |
| first_indexed | 2024-03-12T04:59:20Z |
| format | Article |
| id | doaj.art-1193a6c6737f46a6a4fb5662af48ce73 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T04:59:20Z |
| publishDate | 1997-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-1193a6c6737f46a6a4fb5662af48ce732023-09-03T09:13:58ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601997-01-01925663667Evidentiation of Paramyosin (Sm-97) as a Modulating Antigen on Granulomatous Hypersensitivity to Schistosoma mansoni EggsHirsch CristineCarvalho-Queiroz ClaudiaFranco Gloria RPena Sergio DJSimpson Andrew JGGoes Alfredo MA Schistosoma mansoni adult worm anionic fraction (PIII) has previously been shown to protect mice against challenge infection and to reduce pulmonary and hepatic granulomatous hypersensitivity. Serum from PIII-immunized rabbit was used to screen a lgt11 cDNA library from S. mansoni adult worm in order to identify antigens capable of modulating granulomatous hypersensitivity. We obtained four clones with 400 (Sm-III.11), 900 (Sm-III.16), 1100 (Sm-III.10) and 1300 (Sm-III.12) bp of length. All clone-specific antibodies were able to recognize most of the PIII components. The sequence analysis showed that these clones presented high homology with S. mansoni paramyosin (Sm-97). These findings ascribe a new function to this antigen with an important role in modulation of granulomatous hypersensitivity to S. mansoni eggshttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000500020ParamyosinmodulationgranulomaSchistosoma mansoni |
| spellingShingle | Hirsch Cristine Carvalho-Queiroz Claudia Franco Gloria R Pena Sergio DJ Simpson Andrew JG Goes Alfredo M Evidentiation of Paramyosin (Sm-97) as a Modulating Antigen on Granulomatous Hypersensitivity to Schistosoma mansoni Eggs Memorias do Instituto Oswaldo Cruz Paramyosin modulation granuloma Schistosoma mansoni |
| title | Evidentiation of Paramyosin (Sm-97) as a Modulating Antigen on Granulomatous Hypersensitivity to Schistosoma mansoni Eggs |
| title_full | Evidentiation of Paramyosin (Sm-97) as a Modulating Antigen on Granulomatous Hypersensitivity to Schistosoma mansoni Eggs |
| title_fullStr | Evidentiation of Paramyosin (Sm-97) as a Modulating Antigen on Granulomatous Hypersensitivity to Schistosoma mansoni Eggs |
| title_full_unstemmed | Evidentiation of Paramyosin (Sm-97) as a Modulating Antigen on Granulomatous Hypersensitivity to Schistosoma mansoni Eggs |
| title_short | Evidentiation of Paramyosin (Sm-97) as a Modulating Antigen on Granulomatous Hypersensitivity to Schistosoma mansoni Eggs |
| title_sort | evidentiation of paramyosin sm 97 as a modulating antigen on granulomatous hypersensitivity to schistosoma mansoni eggs |
| topic | Paramyosin modulation granuloma Schistosoma mansoni |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000500020 |
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