THE PROTEIN COMPOSITION OF SUBCELLULAR FRACTIONS SYNCYTIOTROPHOBLAST DURING PHYSIOLOGICAL PREGNANCY AND PLACENTAL INSUFFICIENCY
Purpose: identify changes in the composition of cytoplasmic and membrane proteins of syncytiotrophoblast during placental insufficiency (PI).Materials and methods: we examined 64 women, the study group consisted of 34 patients with PI, a control group of 30 women with physiological pregnancy. Analys...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2013-12-01
|
| Series: | Медицинский вестник Юга России |
| Subjects: | |
| Online Access: | https://www.medicalherald.ru/jour/article/view/155 |
| _version_ | 1811189245364142080 |
|---|---|
| author | T. N. Pogorelova V. O. Gunko V. A. Linde |
| author_facet | T. N. Pogorelova V. O. Gunko V. A. Linde |
| author_sort | T. N. Pogorelova |
| collection | DOAJ |
| description | Purpose: identify changes in the composition of cytoplasmic and membrane proteins of syncytiotrophoblast during placental insufficiency (PI).Materials and methods: we examined 64 women, the study group consisted of 34 patients with PI, a control group of 30 women with physiological pregnancy. Analysis of proteins was performed using a one-dimensional electrophoresis and gelchromatography.Results: carried out researches have allowed to establish in PI reliable differences in the quantity and the mobility of cytoplasmic and membrane proteins of syncytiotrophoblast with different molecular weights. For membrane proteins is also a change in the degree solubilize various detergents.Summary: detected modification of the composition and properties of proteins syncytiotrophoblast expands our understanding of the molecular mechanisms of development of PI. |
| first_indexed | 2024-04-11T14:31:36Z |
| format | Article |
| id | doaj.art-1196637f559d427e90e94e3954301592 |
| institution | Directory Open Access Journal |
| issn | 2219-8075 2618-7876 |
| language | English |
| last_indexed | 2024-04-11T14:31:36Z |
| publishDate | 2013-12-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Медицинский вестник Юга России |
| spelling | doaj.art-1196637f559d427e90e94e39543015922022-12-22T04:18:30ZengState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationМедицинский вестник Юга России2219-80752618-78762013-12-010412513010.21886/2219-8075-2013-4-125-130154THE PROTEIN COMPOSITION OF SUBCELLULAR FRACTIONS SYNCYTIOTROPHOBLAST DURING PHYSIOLOGICAL PREGNANCY AND PLACENTAL INSUFFICIENCYT. N. Pogorelova0V. O. Gunko1V. A. Linde2Rostov Scientific Research Institute of Obstetrics and PediatricsRostov Scientific Research Institute of Obstetrics and PediatricsRostov Scientific Research Institute of Obstetrics and PediatricsPurpose: identify changes in the composition of cytoplasmic and membrane proteins of syncytiotrophoblast during placental insufficiency (PI).Materials and methods: we examined 64 women, the study group consisted of 34 patients with PI, a control group of 30 women with physiological pregnancy. Analysis of proteins was performed using a one-dimensional electrophoresis and gelchromatography.Results: carried out researches have allowed to establish in PI reliable differences in the quantity and the mobility of cytoplasmic and membrane proteins of syncytiotrophoblast with different molecular weights. For membrane proteins is also a change in the degree solubilize various detergents.Summary: detected modification of the composition and properties of proteins syncytiotrophoblast expands our understanding of the molecular mechanisms of development of PI.https://www.medicalherald.ru/jour/article/view/155placentacytoplasmic and membrane proteins of syncytiotrophoblastplacental insufficiency |
| spellingShingle | T. N. Pogorelova V. O. Gunko V. A. Linde THE PROTEIN COMPOSITION OF SUBCELLULAR FRACTIONS SYNCYTIOTROPHOBLAST DURING PHYSIOLOGICAL PREGNANCY AND PLACENTAL INSUFFICIENCY Медицинский вестник Юга России placenta cytoplasmic and membrane proteins of syncytiotrophoblast placental insufficiency |
| title | THE PROTEIN COMPOSITION OF SUBCELLULAR FRACTIONS SYNCYTIOTROPHOBLAST DURING PHYSIOLOGICAL PREGNANCY AND PLACENTAL INSUFFICIENCY |
| title_full | THE PROTEIN COMPOSITION OF SUBCELLULAR FRACTIONS SYNCYTIOTROPHOBLAST DURING PHYSIOLOGICAL PREGNANCY AND PLACENTAL INSUFFICIENCY |
| title_fullStr | THE PROTEIN COMPOSITION OF SUBCELLULAR FRACTIONS SYNCYTIOTROPHOBLAST DURING PHYSIOLOGICAL PREGNANCY AND PLACENTAL INSUFFICIENCY |
| title_full_unstemmed | THE PROTEIN COMPOSITION OF SUBCELLULAR FRACTIONS SYNCYTIOTROPHOBLAST DURING PHYSIOLOGICAL PREGNANCY AND PLACENTAL INSUFFICIENCY |
| title_short | THE PROTEIN COMPOSITION OF SUBCELLULAR FRACTIONS SYNCYTIOTROPHOBLAST DURING PHYSIOLOGICAL PREGNANCY AND PLACENTAL INSUFFICIENCY |
| title_sort | protein composition of subcellular fractions syncytiotrophoblast during physiological pregnancy and placental insufficiency |
| topic | placenta cytoplasmic and membrane proteins of syncytiotrophoblast placental insufficiency |
| url | https://www.medicalherald.ru/jour/article/view/155 |
| work_keys_str_mv | AT tnpogorelova theproteincompositionofsubcellularfractionssyncytiotrophoblastduringphysiologicalpregnancyandplacentalinsufficiency AT vogunko theproteincompositionofsubcellularfractionssyncytiotrophoblastduringphysiologicalpregnancyandplacentalinsufficiency AT valinde theproteincompositionofsubcellularfractionssyncytiotrophoblastduringphysiologicalpregnancyandplacentalinsufficiency AT tnpogorelova proteincompositionofsubcellularfractionssyncytiotrophoblastduringphysiologicalpregnancyandplacentalinsufficiency AT vogunko proteincompositionofsubcellularfractionssyncytiotrophoblastduringphysiologicalpregnancyandplacentalinsufficiency AT valinde proteincompositionofsubcellularfractionssyncytiotrophoblastduringphysiologicalpregnancyandplacentalinsufficiency |