Pentamidine Alleviates Inflammation and Lipopolysaccharide-Induced Sepsis by Inhibiting TLR4 Activation via Targeting MD2

Pentamidine Alleviates Inflammation and Lipopolysaccharide-Induced Sepsis by Inhibiting TLR4 Activation via Targeting MD2

Toll-like receptor 4 (TLR4) is a pattern-recognition receptor (PRR) that can recognize lipopolysaccharides (LPS) and initiate the immune response, to protect the body from infection. However, excessive activation of TLR4 induced by LPS leads to substantial release of pro-inflammatory factors, which...

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Bibliographic Details
Main Authors: Siru Wu, Cong Lin, Tianshu Zhang, Bo Zhang, Yushan Jin, Hongshuang Wang, Hongyuan Li, Yibo Wang, Xiaohui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
Toll-like receptor 4
myeloid differentiation protein 2
pentamidine
inflammation
sepsis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.835081/full

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