Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective study
Abstract Background Lung ultrasound allows lung aeration to be assessed through dedicated lung ultrasound scores (LUS). Despite LUS have been validated using several techniques, scanty data exist about the relationships between LUS and compliance of the respiratory system (Crs) in restrictive respir...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-022-02294-1 |
| _version_ | 1811196618339254272 |
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| author | Daniele Guerino Biasucci Barbara Loi Roberta Centorrino Roberto Raschetti Marco Piastra Luca Pisapia Ludovica Maria Consalvo Anselmo Caricato Domenico Luca Grieco Giorgio Conti Massimo Antonelli Daniele De Luca |
| author_facet | Daniele Guerino Biasucci Barbara Loi Roberta Centorrino Roberto Raschetti Marco Piastra Luca Pisapia Ludovica Maria Consalvo Anselmo Caricato Domenico Luca Grieco Giorgio Conti Massimo Antonelli Daniele De Luca |
| author_sort | Daniele Guerino Biasucci |
| collection | DOAJ |
| description | Abstract Background Lung ultrasound allows lung aeration to be assessed through dedicated lung ultrasound scores (LUS). Despite LUS have been validated using several techniques, scanty data exist about the relationships between LUS and compliance of the respiratory system (Crs) in restrictive respiratory failure. Aim of this study was to investigate the relationship between LUS and Crs in neonates and adults affected by acute hypoxemic restrictive respiratory failure, as well as the effect of patients’ age on this relationship. Methods Observational, cross-sectional, international, patho-physiology, bi-center study recruiting invasively ventilated, adults and neonates with acute respiratory distress syndrome (ARDS), neonatal ARDS (NARDS) or respiratory distress syndrome (RDS) due to primary surfactant deficiency. Subjects without lung disease (NLD) and ventilated for extra-pulmonary conditions were recruited as controls. LUS, Crs and resistances (Rrs) of the respiratory system were measured within 1 h from each other. Results Forty adults and fifty-six neonates were recruited. LUS was higher in ARDS, NARDS and RDS and lower in control subjects (overall p < 0.001), while Crs was lower in ARDS, NARDS and RDS and higher in control subjects (overall p < 0.001), without differences between adults and neonates. LUS and Crs were correlated in adults [r = − 0.86 (95% CI − 0.93; − 0.76), p < 0.001] and neonates [r = − 0.76 (95% CI − 0.85; − 0.62), p < 0.001]. Correlations remained significant among subgroups with different causes of respiratory failure; LUS and Rrs were not correlated. Multivariate analyses confirmed the association between LUS and Crs both in adults [B = − 2.8 (95% CI − 4.9; − 0.6), p = 0.012] and neonates [B = − 0.045 (95% CI − 0.07; − 0.02), p = 0.001]. Conclusions Lung aeration and compliance of the respiratory system are significantly and inversely correlated irrespective of patients’ age. A restrictive respiratory failure has the same ultrasound appearance and mechanical characteristics in adults and neonates. |
| first_indexed | 2024-04-12T01:01:54Z |
| format | Article |
| id | doaj.art-11983359af984186b551821935d8ad80 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-12T01:01:54Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-11983359af984186b551821935d8ad802022-12-22T03:54:25ZengBMCRespiratory Research1465-993X2022-12-012311910.1186/s12931-022-02294-1Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective studyDaniele Guerino Biasucci0Barbara Loi1Roberta Centorrino2Roberto Raschetti3Marco Piastra4Luca Pisapia5Ludovica Maria Consalvo6Anselmo Caricato7Domenico Luca Grieco8Giorgio Conti9Massimo Antonelli10Daniele De Luca11Department of Emergency, Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario “A. Gemelli” IRCCSDivision of Pediatrics and Neonatal Critical Care, A. Béclère Medical Center, Paris-Saclay University Hospitals, Public Assistance – Paris HospitalsDivision of Pediatrics and Neonatal Critical Care, A. Béclère Medical Center, Paris-Saclay University Hospitals, Public Assistance – Paris HospitalsDivision of Pediatrics and Neonatal Critical Care, A. Béclère Medical Center, Paris-Saclay University Hospitals, Public Assistance – Paris HospitalsDepartment of Emergency, Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario “A. Gemelli” IRCCSDepartment of Emergency, Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario “A. Gemelli” IRCCSAnesthesiology and Intensive Care, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoDepartment of Emergency, Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario “A. Gemelli” IRCCSDepartment of Emergency, Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario “A. Gemelli” IRCCSDepartment of Emergency, Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario “A. Gemelli” IRCCSDepartment of Emergency, Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario “A. Gemelli” IRCCSDivision of Pediatrics and Neonatal Critical Care, A. Béclère Medical Center, Paris-Saclay University Hospitals, Public Assistance – Paris HospitalsAbstract Background Lung ultrasound allows lung aeration to be assessed through dedicated lung ultrasound scores (LUS). Despite LUS have been validated using several techniques, scanty data exist about the relationships between LUS and compliance of the respiratory system (Crs) in restrictive respiratory failure. Aim of this study was to investigate the relationship between LUS and Crs in neonates and adults affected by acute hypoxemic restrictive respiratory failure, as well as the effect of patients’ age on this relationship. Methods Observational, cross-sectional, international, patho-physiology, bi-center study recruiting invasively ventilated, adults and neonates with acute respiratory distress syndrome (ARDS), neonatal ARDS (NARDS) or respiratory distress syndrome (RDS) due to primary surfactant deficiency. Subjects without lung disease (NLD) and ventilated for extra-pulmonary conditions were recruited as controls. LUS, Crs and resistances (Rrs) of the respiratory system were measured within 1 h from each other. Results Forty adults and fifty-six neonates were recruited. LUS was higher in ARDS, NARDS and RDS and lower in control subjects (overall p < 0.001), while Crs was lower in ARDS, NARDS and RDS and higher in control subjects (overall p < 0.001), without differences between adults and neonates. LUS and Crs were correlated in adults [r = − 0.86 (95% CI − 0.93; − 0.76), p < 0.001] and neonates [r = − 0.76 (95% CI − 0.85; − 0.62), p < 0.001]. Correlations remained significant among subgroups with different causes of respiratory failure; LUS and Rrs were not correlated. Multivariate analyses confirmed the association between LUS and Crs both in adults [B = − 2.8 (95% CI − 4.9; − 0.6), p = 0.012] and neonates [B = − 0.045 (95% CI − 0.07; − 0.02), p = 0.001]. Conclusions Lung aeration and compliance of the respiratory system are significantly and inversely correlated irrespective of patients’ age. A restrictive respiratory failure has the same ultrasound appearance and mechanical characteristics in adults and neonates.https://doi.org/10.1186/s12931-022-02294-1Acute respiratory distress syndromeLung mechanicsLung ultrasoundNeonates |
| spellingShingle | Daniele Guerino Biasucci Barbara Loi Roberta Centorrino Roberto Raschetti Marco Piastra Luca Pisapia Ludovica Maria Consalvo Anselmo Caricato Domenico Luca Grieco Giorgio Conti Massimo Antonelli Daniele De Luca Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective study Respiratory Research Acute respiratory distress syndrome Lung mechanics Lung ultrasound Neonates |
| title | Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective study |
| title_full | Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective study |
| title_fullStr | Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective study |
| title_full_unstemmed | Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective study |
| title_short | Ultrasound-assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure: an observational prospective study |
| title_sort | ultrasound assessed lung aeration correlates with respiratory system compliance in adults and neonates with acute hypoxemic restrictive respiratory failure an observational prospective study |
| topic | Acute respiratory distress syndrome Lung mechanics Lung ultrasound Neonates |
| url | https://doi.org/10.1186/s12931-022-02294-1 |
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