Screening of mucoadhesive vaginal gel formulations
Rational design of vaginal drug delivery formulations requires special attention to vehicle properties that optimize vaginal coating and retention. The aim of the present work was to perform a screening of mucoadhesive vaginal gels formulated with carbomer or carrageenan in binary combination with a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2014-12-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400931&lng=en&tlng=en |
| _version_ | 1819048897412071424 |
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| author | Ana Ochoa Andrade María Emma Parente Gastón Ares |
| author_facet | Ana Ochoa Andrade María Emma Parente Gastón Ares |
| author_sort | Ana Ochoa Andrade |
| collection | DOAJ |
| description | Rational design of vaginal drug delivery formulations requires special attention to vehicle properties that optimize vaginal coating and retention. The aim of the present work was to perform a screening of mucoadhesive vaginal gels formulated with carbomer or carrageenan in binary combination with a second polymer (carbomer, guar or xanthan gum). The gels were characterised using in vitroadhesion, spreadability and leakage potential studies, as well as rheological measurements (stress and frequency sweep tests) and the effect of dilution with simulated vaginal fluid (SVF) on spreadability. Results were analysed using analysis of variance and multiple factor analysis. The combination of polymers enhanced adhesion of both primary gelling agents, carbomer and carrageenan. From the rheological point of view all formulations presented a similar behaviour, prevalently elastic and characterised by loss tangent values well below 1. No correlation between rheological and adhesion behaviour was found. Carbomer and carrageenan gels containing the highest percentage of xanthan gum displayed good in vitro mucoadhesion and spreadability, minimal leakage potential and high resistance to dilution. The positive results obtained with carrageenan-xanthan gum-based gels can encourage the use of natural biocompatible adjuvants in the composition of vaginal products, a formulation field that is currently under the synthetic domain. |
| first_indexed | 2024-12-21T11:23:33Z |
| format | Article |
| id | doaj.art-119844909abd4b15a5ab49765a6c679c |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-21T11:23:33Z |
| publishDate | 2014-12-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-119844909abd4b15a5ab49765a6c679c2022-12-21T19:05:43ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902014-12-0150493194110.1590/S1984-82502014000400029S1984-82502014000400931Screening of mucoadhesive vaginal gel formulationsAna Ochoa AndradeMaría Emma ParenteGastón AresRational design of vaginal drug delivery formulations requires special attention to vehicle properties that optimize vaginal coating and retention. The aim of the present work was to perform a screening of mucoadhesive vaginal gels formulated with carbomer or carrageenan in binary combination with a second polymer (carbomer, guar or xanthan gum). The gels were characterised using in vitroadhesion, spreadability and leakage potential studies, as well as rheological measurements (stress and frequency sweep tests) and the effect of dilution with simulated vaginal fluid (SVF) on spreadability. Results were analysed using analysis of variance and multiple factor analysis. The combination of polymers enhanced adhesion of both primary gelling agents, carbomer and carrageenan. From the rheological point of view all formulations presented a similar behaviour, prevalently elastic and characterised by loss tangent values well below 1. No correlation between rheological and adhesion behaviour was found. Carbomer and carrageenan gels containing the highest percentage of xanthan gum displayed good in vitro mucoadhesion and spreadability, minimal leakage potential and high resistance to dilution. The positive results obtained with carrageenan-xanthan gum-based gels can encourage the use of natural biocompatible adjuvants in the composition of vaginal products, a formulation field that is currently under the synthetic domain.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400931&lng=en&tlng=enGéis vaginais mucoadesivos/triagemGoma xantana/uso/produtos vaginaisMucoadesãoProdutos vaginais/reologiaProdutos vaginais/espalhabilidadeProdutos naturais/uso/géis vaginais |
| spellingShingle | Ana Ochoa Andrade María Emma Parente Gastón Ares Screening of mucoadhesive vaginal gel formulations Brazilian Journal of Pharmaceutical Sciences Géis vaginais mucoadesivos/triagem Goma xantana/uso/produtos vaginais Mucoadesão Produtos vaginais/reologia Produtos vaginais/espalhabilidade Produtos naturais/uso/géis vaginais |
| title | Screening of mucoadhesive vaginal gel formulations |
| title_full | Screening of mucoadhesive vaginal gel formulations |
| title_fullStr | Screening of mucoadhesive vaginal gel formulations |
| title_full_unstemmed | Screening of mucoadhesive vaginal gel formulations |
| title_short | Screening of mucoadhesive vaginal gel formulations |
| title_sort | screening of mucoadhesive vaginal gel formulations |
| topic | Géis vaginais mucoadesivos/triagem Goma xantana/uso/produtos vaginais Mucoadesão Produtos vaginais/reologia Produtos vaginais/espalhabilidade Produtos naturais/uso/géis vaginais |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400931&lng=en&tlng=en |
| work_keys_str_mv | AT anaochoaandrade screeningofmucoadhesivevaginalgelformulations AT mariaemmaparente screeningofmucoadhesivevaginalgelformulations AT gastonares screeningofmucoadhesivevaginalgelformulations |