Clinical implications of advances in liver regeneration
Remarkable advances have been made recently in the area of liver regeneration. Even though liver regeneration after liver resection has been widely researched, new clinical applications have provided a better understanding of the process. Hepatic damage induces a process of regeneration that rarely...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Association for the Study of the Liver
2015-03-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-21-7.pdf |
| _version_ | 1818302951870955520 |
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| author | Yong Jin Kwon Kyeong Geun Lee Dongho Choi |
| author_facet | Yong Jin Kwon Kyeong Geun Lee Dongho Choi |
| author_sort | Yong Jin Kwon |
| collection | DOAJ |
| description | Remarkable advances have been made recently in the area of liver regeneration. Even though liver regeneration after liver resection has been widely researched, new clinical applications have provided a better understanding of the process. Hepatic damage induces a process of regeneration that rarely occurs in normal undamaged liver. Many studies have concentrated on the mechanism of hepatocyte regeneration following liver damage. High mortality is usual in patients with terminal liver failure. Patients die when the regenerative process is unable to balance loss due to liver damage. During disease progression, cellular adaptations take place and the organ microenvironment changes. Portal vein embolization and the associating liver partition and portal vein ligation for staged hepatectomy are relatively recent techniques exploiting the remarkable progress in understanding liver regeneration. Living donor liver transplantation is one of the most significant clinical outcomes of research on liver regeneration. Another major clinical field involving liver regeneration is cell therapy using adult stem cells. The aim of this article is to provide an outline of the clinical approaches being undertaken to examine regeneration in liver diseases. |
| first_indexed | 2024-12-13T05:47:04Z |
| format | Article |
| id | doaj.art-11986c385b214b4d886292fccc3c25cd |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-12-13T05:47:04Z |
| publishDate | 2015-03-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-11986c385b214b4d886292fccc3c25cd2022-12-21T23:57:39ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2015-03-0121171310.3350/cmh.2015.21.1.71173Clinical implications of advances in liver regenerationYong Jin Kwon0Kyeong Geun Lee1Dongho Choi2Department of Surgery, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul, Korea.Department of Surgery, Hanyang University College of Medicine, Seoul, Korea.Department of Surgery, Hanyang University College of Medicine, Seoul, Korea.Remarkable advances have been made recently in the area of liver regeneration. Even though liver regeneration after liver resection has been widely researched, new clinical applications have provided a better understanding of the process. Hepatic damage induces a process of regeneration that rarely occurs in normal undamaged liver. Many studies have concentrated on the mechanism of hepatocyte regeneration following liver damage. High mortality is usual in patients with terminal liver failure. Patients die when the regenerative process is unable to balance loss due to liver damage. During disease progression, cellular adaptations take place and the organ microenvironment changes. Portal vein embolization and the associating liver partition and portal vein ligation for staged hepatectomy are relatively recent techniques exploiting the remarkable progress in understanding liver regeneration. Living donor liver transplantation is one of the most significant clinical outcomes of research on liver regeneration. Another major clinical field involving liver regeneration is cell therapy using adult stem cells. The aim of this article is to provide an outline of the clinical approaches being undertaken to examine regeneration in liver diseases.http://e-cmh.org/upload/pdf/cmh-21-7.pdfLiver regenerationHepatectomyLiver transplantation |
| spellingShingle | Yong Jin Kwon Kyeong Geun Lee Dongho Choi Clinical implications of advances in liver regeneration Clinical and Molecular Hepatology Liver regeneration Hepatectomy Liver transplantation |
| title | Clinical implications of advances in liver regeneration |
| title_full | Clinical implications of advances in liver regeneration |
| title_fullStr | Clinical implications of advances in liver regeneration |
| title_full_unstemmed | Clinical implications of advances in liver regeneration |
| title_short | Clinical implications of advances in liver regeneration |
| title_sort | clinical implications of advances in liver regeneration |
| topic | Liver regeneration Hepatectomy Liver transplantation |
| url | http://e-cmh.org/upload/pdf/cmh-21-7.pdf |
| work_keys_str_mv | AT yongjinkwon clinicalimplicationsofadvancesinliverregeneration AT kyeonggeunlee clinicalimplicationsofadvancesinliverregeneration AT donghochoi clinicalimplicationsofadvancesinliverregeneration |