XRCC4 rs28360071 intronic variant is associated with increased risk for infant acute lymphoblastic leukemia with KMT2A rearrangements

XRCC4 rs28360071 intronic variant is associated with increased risk for infant acute lymphoblastic leukemia with KMT2A rearrangements

Abstract Early age acute leukemia (EAL) shows a high frequency of KMT2A-rearrangements (KMT2A-r). Previous investigations highlighted double-strand breaks arising from maternal exposure to xenobiotics during pregnancy as a risk factor for EAL and KMT2A-r. In this case-control study, we investigated...

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Bibliographic Details
Main Authors: Orlando Louzada-Neto, Bruno A. Lopes, Gisele D. Brisson, Francianne G. Andrade, Ingrid S. Cezar, Cíntia B. Santos-Rebouças, Rodolpho M. Albano, Maria S. Pombo-de-Oliveira, Ana Rossini
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2020-12-01
Series:Genetics and Molecular Biology
Subjects:
Early age acute leukemia
nonhomologous end-joining
XRCC4
XRCC6
KMT2A
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000600111&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000600111&tlng=en

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