A Novel N of 1 Trial Design and Proposed Utility in Complementary and Alternative Medicine Research
An N of 1 trial is a multiple crossover study in a single participant. N of 1trials can combine the benefits of individualized patient practice and evidence-based medicine and are amenable to complementary and alternative medicine practice and research. This article will review the basic structure o...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2012-04-01
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| Series: | Journal of Evidence-Based Complementary & Alternative Medicine |
| Online Access: | https://doi.org/10.1177/2156587212437556 |
| _version_ | 1818540372898349056 |
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| author | Joshua Z. Goldenberg BA Cynthia A. Wenner PhD |
| author_facet | Joshua Z. Goldenberg BA Cynthia A. Wenner PhD |
| author_sort | Joshua Z. Goldenberg BA |
| collection | DOAJ |
| description | An N of 1 trial is a multiple crossover study in a single participant. N of 1trials can combine the benefits of individualized patient practice and evidence-based medicine and are amenable to complementary and alternative medicine practice and research. This article will review the basic structure of N of 1trials, discuss how they are commonly used, and review their limitations and statistical considerations. The authors also propose a novel use of the N of 1 trial in the form of mixed-methodology add-on N of 1 trials targeted to a parent trial’s responders. This design can help uncover evidence of subgroup effects in small trials, address issues surrounding the small study effect, and explore the role of interparticipant variability and random chance in the parent trial. |
| first_indexed | 2024-12-11T21:54:29Z |
| format | Article |
| id | doaj.art-1198ed3c408c4dc78d8c9ddbe3670c5c |
| institution | Directory Open Access Journal |
| issn | 2156-5872 2156-5899 |
| language | English |
| last_indexed | 2024-12-11T21:54:29Z |
| publishDate | 2012-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Evidence-Based Complementary & Alternative Medicine |
| spelling | doaj.art-1198ed3c408c4dc78d8c9ddbe3670c5c2022-12-22T00:49:21ZengSAGE PublishingJournal of Evidence-Based Complementary & Alternative Medicine2156-58722156-58992012-04-011710.1177/2156587212437556A Novel N of 1 Trial Design and Proposed Utility in Complementary and Alternative Medicine ResearchJoshua Z. Goldenberg BA0Cynthia A. Wenner PhD1Bastyr University, Kenmore, WA, USABastyr University, Kenmore, WA, USAAn N of 1 trial is a multiple crossover study in a single participant. N of 1trials can combine the benefits of individualized patient practice and evidence-based medicine and are amenable to complementary and alternative medicine practice and research. This article will review the basic structure of N of 1trials, discuss how they are commonly used, and review their limitations and statistical considerations. The authors also propose a novel use of the N of 1 trial in the form of mixed-methodology add-on N of 1 trials targeted to a parent trial’s responders. This design can help uncover evidence of subgroup effects in small trials, address issues surrounding the small study effect, and explore the role of interparticipant variability and random chance in the parent trial.https://doi.org/10.1177/2156587212437556 |
| spellingShingle | Joshua Z. Goldenberg BA Cynthia A. Wenner PhD A Novel N of 1 Trial Design and Proposed Utility in Complementary and Alternative Medicine Research Journal of Evidence-Based Complementary & Alternative Medicine |
| title | A Novel N of 1 Trial Design and Proposed Utility in Complementary and Alternative Medicine Research |
| title_full | A Novel N of 1 Trial Design and Proposed Utility in Complementary and Alternative Medicine Research |
| title_fullStr | A Novel N of 1 Trial Design and Proposed Utility in Complementary and Alternative Medicine Research |
| title_full_unstemmed | A Novel N of 1 Trial Design and Proposed Utility in Complementary and Alternative Medicine Research |
| title_short | A Novel N of 1 Trial Design and Proposed Utility in Complementary and Alternative Medicine Research |
| title_sort | novel n of 1 trial design and proposed utility in complementary and alternative medicine research |
| url | https://doi.org/10.1177/2156587212437556 |
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