Casein Kinase 2 (CK2): A Possible Therapeutic Target in Acute Myeloid Leukemia
The protein kinase CK2 (also known as casein kinase 2) is one of the main contributors to the human phosphoproteome. It is regarded as a possible therapeutic strategy in several malignant diseases, including acute myeloid leukemia (AML), which is an aggressive bone marrow malignancy. CK2 is an impor...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/14/3711 |
| _version_ | 1797589873133092864 |
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| author | Øystein Bruserud Håkon Reikvam |
| author_facet | Øystein Bruserud Håkon Reikvam |
| author_sort | Øystein Bruserud |
| collection | DOAJ |
| description | The protein kinase CK2 (also known as casein kinase 2) is one of the main contributors to the human phosphoproteome. It is regarded as a possible therapeutic strategy in several malignant diseases, including acute myeloid leukemia (AML), which is an aggressive bone marrow malignancy. CK2 is an important regulator of intracellular signaling in AML cells, especially PI3K–Akt, Jak–Stat, NFκB, Wnt, and DNA repair signaling. High CK2 levels in AML cells at the first time of diagnosis are associated with decreased survival (i.e., increased risk of chemoresistant leukemia relapse) for patients receiving intensive and potentially curative antileukemic therapy. However, it is not known whether these high CK2 levels can be used as an independent prognostic biomarker because this has not been investigated in multivariate analyses. Several CK2 inhibitors have been developed, but CX-4945/silmitasertib is best characterized. This drug has antiproliferative and proapoptotic effects in primary human AML cells. The preliminary results from studies of silmitasertib in the treatment of other malignancies suggest that gastrointestinal and bone marrow toxicities are relatively common. However, clinical AML studies are not available. Taken together, the available experimental and clinical evidence suggests that the possible use of CK2 inhibition in the treatment of AML should be further investigated. |
| first_indexed | 2024-03-11T01:12:17Z |
| format | Article |
| id | doaj.art-119a5568a423458a9bb693c84992703d |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T01:12:17Z |
| publishDate | 2023-07-01 |
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| series | Cancers |
| spelling | doaj.art-119a5568a423458a9bb693c84992703d2023-11-18T18:43:02ZengMDPI AGCancers2072-66942023-07-011514371110.3390/cancers15143711Casein Kinase 2 (CK2): A Possible Therapeutic Target in Acute Myeloid LeukemiaØystein Bruserud0Håkon Reikvam1Institute for Clinical Science, Faculty of Medicine, University of Bergen, 5021 Bergen, NorwayInstitute for Clinical Science, Faculty of Medicine, University of Bergen, 5021 Bergen, NorwayThe protein kinase CK2 (also known as casein kinase 2) is one of the main contributors to the human phosphoproteome. It is regarded as a possible therapeutic strategy in several malignant diseases, including acute myeloid leukemia (AML), which is an aggressive bone marrow malignancy. CK2 is an important regulator of intracellular signaling in AML cells, especially PI3K–Akt, Jak–Stat, NFκB, Wnt, and DNA repair signaling. High CK2 levels in AML cells at the first time of diagnosis are associated with decreased survival (i.e., increased risk of chemoresistant leukemia relapse) for patients receiving intensive and potentially curative antileukemic therapy. However, it is not known whether these high CK2 levels can be used as an independent prognostic biomarker because this has not been investigated in multivariate analyses. Several CK2 inhibitors have been developed, but CX-4945/silmitasertib is best characterized. This drug has antiproliferative and proapoptotic effects in primary human AML cells. The preliminary results from studies of silmitasertib in the treatment of other malignancies suggest that gastrointestinal and bone marrow toxicities are relatively common. However, clinical AML studies are not available. Taken together, the available experimental and clinical evidence suggests that the possible use of CK2 inhibition in the treatment of AML should be further investigated.https://www.mdpi.com/2072-6694/15/14/3711CK2acute myeloid leukemiaprognosissilmitasertibchemotherapychemoresistance |
| spellingShingle | Øystein Bruserud Håkon Reikvam Casein Kinase 2 (CK2): A Possible Therapeutic Target in Acute Myeloid Leukemia Cancers CK2 acute myeloid leukemia prognosis silmitasertib chemotherapy chemoresistance |
| title | Casein Kinase 2 (CK2): A Possible Therapeutic Target in Acute Myeloid Leukemia |
| title_full | Casein Kinase 2 (CK2): A Possible Therapeutic Target in Acute Myeloid Leukemia |
| title_fullStr | Casein Kinase 2 (CK2): A Possible Therapeutic Target in Acute Myeloid Leukemia |
| title_full_unstemmed | Casein Kinase 2 (CK2): A Possible Therapeutic Target in Acute Myeloid Leukemia |
| title_short | Casein Kinase 2 (CK2): A Possible Therapeutic Target in Acute Myeloid Leukemia |
| title_sort | casein kinase 2 ck2 a possible therapeutic target in acute myeloid leukemia |
| topic | CK2 acute myeloid leukemia prognosis silmitasertib chemotherapy chemoresistance |
| url | https://www.mdpi.com/2072-6694/15/14/3711 |
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