Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Biomedicine & Pharmacotherapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222005376 |
| _version_ | 1811332060862742528 |
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| author | Basista Rabina Sharma Swarna Jaiswal P.V. Ravindra |
| author_facet | Basista Rabina Sharma Swarna Jaiswal P.V. Ravindra |
| author_sort | Basista Rabina Sharma |
| collection | DOAJ |
| description | Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the GM for the prevention and management of T2DM. |
| first_indexed | 2024-04-13T16:31:07Z |
| format | Article |
| id | doaj.art-119a78acbfe5451b97c1e170ea4f2f05 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T16:31:07Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-119a78acbfe5451b97c1e170ea4f2f052022-12-22T02:39:34ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-08-01152113148Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetesBasista Rabina Sharma0Swarna Jaiswal1P.V. Ravindra2Department of Biochemistry, CSIR-Central Food Technological Research Institute (CFTRI), KRS Road, Opp. Rail Museum, Mysuru 570020, IndiaSchool of Food Science and Environmental Health, College of Sciences and Health, Technological University Dublin - City Campus, Central Quad, Grangegorman, Dublin D07 ADY7, Ireland; Environmental Sustainability and Health Institute, Technological University Dublin - City Campus, Grangegorman, Dublin D07 H6K8, IrelandDepartment of Biochemistry, CSIR-Central Food Technological Research Institute (CFTRI), KRS Road, Opp. Rail Museum, Mysuru 570020, India; Corresponding author.Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the GM for the prevention and management of T2DM.http://www.sciencedirect.com/science/article/pii/S0753332222005376Type 2 diabetesGut microbiotaEubiosisDysbiosis |
| spellingShingle | Basista Rabina Sharma Swarna Jaiswal P.V. Ravindra Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes Biomedicine & Pharmacotherapy Type 2 diabetes Gut microbiota Eubiosis Dysbiosis |
| title | Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes |
| title_full | Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes |
| title_fullStr | Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes |
| title_full_unstemmed | Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes |
| title_short | Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes |
| title_sort | modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes |
| topic | Type 2 diabetes Gut microbiota Eubiosis Dysbiosis |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222005376 |
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