Effect of tamoxifen-loaded transdermal patch on physical and biochemical parameters in DMBA-induced breast cancer
Background: The current study assessed the effect of tamoxifen-loaded transdermal patch in Dimethylbenz(a)anthracene (DMBA)-induced breast cancer. Materials and Methods: Different formulations composed of various concentrations of tamoxifen citrate, poly (SA: RA), glucose, mannitol were formulated a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2020-01-01
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| Series: | Indian Journal of Health Sciences and Biomedical Research KLEU |
| Subjects: | |
| Online Access: | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2020;volume=13;issue=3;spage=230;epage=234;aulast=Adhyapak |
| _version_ | 1818382895683731456 |
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| author | Anjana Adhyapak B G Desai |
| author_facet | Anjana Adhyapak B G Desai |
| author_sort | Anjana Adhyapak |
| collection | DOAJ |
| description | Background: The current study assessed the effect of tamoxifen-loaded transdermal patch in Dimethylbenz(a)anthracene (DMBA)-induced breast cancer.
Materials and Methods: Different formulations composed of various concentrations of tamoxifen citrate, poly (SA: RA), glucose, mannitol were formulated and were evaluated in DMBAinduced breast cancer in female albino Wistar rats. Multiple parameters such as body weight, hemoglobin content, red blood cell, white blood cell, SGPT, and SGOT were evaluated.
Results: Treatment with formulations showed a decrease in body weight contrast to disease. Equally, a considerable increase in hemoglobin was observed in the formulation treated group over disease grouping. Likewise, there decrease in SGPT and SGOT in formulation compared to disease.
Conclusion: The present study revealed a transdermal patch loaded with tamoxifen showed promising antitumor activity. |
| first_indexed | 2024-12-14T02:57:44Z |
| format | Article |
| id | doaj.art-119bb7cc9c59492b8c1fd02e116ecc8e |
| institution | Directory Open Access Journal |
| issn | 2542-6214 2542-6222 |
| language | English |
| last_indexed | 2024-12-14T02:57:44Z |
| publishDate | 2020-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Health Sciences and Biomedical Research KLEU |
| spelling | doaj.art-119bb7cc9c59492b8c1fd02e116ecc8e2022-12-21T23:19:35ZengWolters Kluwer Medknow PublicationsIndian Journal of Health Sciences and Biomedical Research KLEU2542-62142542-62222020-01-0113323023410.4103/kleuhsj.kleuhsj_38_20Effect of tamoxifen-loaded transdermal patch on physical and biochemical parameters in DMBA-induced breast cancerAnjana AdhyapakB G DesaiBackground: The current study assessed the effect of tamoxifen-loaded transdermal patch in Dimethylbenz(a)anthracene (DMBA)-induced breast cancer. Materials and Methods: Different formulations composed of various concentrations of tamoxifen citrate, poly (SA: RA), glucose, mannitol were formulated and were evaluated in DMBAinduced breast cancer in female albino Wistar rats. Multiple parameters such as body weight, hemoglobin content, red blood cell, white blood cell, SGPT, and SGOT were evaluated. Results: Treatment with formulations showed a decrease in body weight contrast to disease. Equally, a considerable increase in hemoglobin was observed in the formulation treated group over disease grouping. Likewise, there decrease in SGPT and SGOT in formulation compared to disease. Conclusion: The present study revealed a transdermal patch loaded with tamoxifen showed promising antitumor activity.http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2020;volume=13;issue=3;spage=230;epage=234;aulast=Adhyapakanticancernanoformulationtamoxifentransdermal patch |
| spellingShingle | Anjana Adhyapak B G Desai Effect of tamoxifen-loaded transdermal patch on physical and biochemical parameters in DMBA-induced breast cancer Indian Journal of Health Sciences and Biomedical Research KLEU anticancer nanoformulation tamoxifen transdermal patch |
| title | Effect of tamoxifen-loaded transdermal patch on physical and biochemical parameters in DMBA-induced breast cancer |
| title_full | Effect of tamoxifen-loaded transdermal patch on physical and biochemical parameters in DMBA-induced breast cancer |
| title_fullStr | Effect of tamoxifen-loaded transdermal patch on physical and biochemical parameters in DMBA-induced breast cancer |
| title_full_unstemmed | Effect of tamoxifen-loaded transdermal patch on physical and biochemical parameters in DMBA-induced breast cancer |
| title_short | Effect of tamoxifen-loaded transdermal patch on physical and biochemical parameters in DMBA-induced breast cancer |
| title_sort | effect of tamoxifen loaded transdermal patch on physical and biochemical parameters in dmba induced breast cancer |
| topic | anticancer nanoformulation tamoxifen transdermal patch |
| url | http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2020;volume=13;issue=3;spage=230;epage=234;aulast=Adhyapak |
| work_keys_str_mv | AT anjanaadhyapak effectoftamoxifenloadedtransdermalpatchonphysicalandbiochemicalparametersindmbainducedbreastcancer AT bgdesai effectoftamoxifenloadedtransdermalpatchonphysicalandbiochemicalparametersindmbainducedbreastcancer |