Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive, genomically complex, have soft tissue sarcomas, and are derived from the Schwann cell lineage. Patients with neurofibromatosis type 1 syndrome (NF1), an autosomal dominant tumor predisposition syndrome, are at a high risk for M...
Main Authors: | Germán L. Vélez-Reyes, Nicholas Koes, Ji Hae Ryu, Gabriel Kaufmann, Mariah Berner, Madison T. Weg, Natalie K. Wolf, Susan K. Rathe, Nancy Ratner, Branden S. Moriarity, David A. Largaespada |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-03-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/13/7/1584 |
Similar Items
-
Practical Approach to Histological Diagnosis of Peripheral Nerve Sheath Tumors: An Update
by: Gaetano Magro, et al.
Published: (2022-06-01) -
Diagnostic and therapeutic process of neurofibromatosis type 1 and type 2
by: Michał Leśniewski, et al.
Published: (2024-02-01) -
Malignant peripheral nerve sheath tumours and neurofibromatosis 1: A case series and recommendations for care
by: Henriette Burger, et al.
Published: (2018-08-01) -
New Model Systems and the Development of Targeted Therapies for the Treatment of Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheath Tumors
by: Kyle B. Williams, et al.
Published: (2020-04-01) -
"Site-selected" transposon mutagenesis of Drosophila.
by: Kaiser, K, et al.
Published: (1990)