Body composition and risk factors associated with sarcopenia in post-COVID patients after moderate or severe COVID-19 infections
Abstract Background Post-COVID-19 syndrome is characterized by diverse symptoms and abnormalities that persist beyond 12 weeks from the onset of acute COVID-19. Severity disease has been associated with more musculoskeletal alterations such as muscle weakness, dyspnea, and distance walking. The aim...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-06-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-022-02014-x |
| _version_ | 1818252983129866240 |
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| author | Dulce González-Islas Carlos Sánchez-Moreno Arturo Orea-Tejeda Samantha Hernández-López Fernanda Salgado-Fernández Candace Keirns-Davis Susana Galicia-Amor Esperanza Trejo-Mellado Laura Gochicoa-Rangel Armando Castorena-Maldonado |
| author_facet | Dulce González-Islas Carlos Sánchez-Moreno Arturo Orea-Tejeda Samantha Hernández-López Fernanda Salgado-Fernández Candace Keirns-Davis Susana Galicia-Amor Esperanza Trejo-Mellado Laura Gochicoa-Rangel Armando Castorena-Maldonado |
| author_sort | Dulce González-Islas |
| collection | DOAJ |
| description | Abstract Background Post-COVID-19 syndrome is characterized by diverse symptoms and abnormalities that persist beyond 12 weeks from the onset of acute COVID-19. Severity disease has been associated with more musculoskeletal alterations such as muscle weakness, dyspnea, and distance walking. The aim was to evaluate the impact of invasive mechanical ventilation (IMV) on body composition and investigate risk factors associated with sarcopenia in post-COVID-19 patients three months after moderate or severe COVID-19 infections. Methods Cross-sectional study. 530 patients with PCR-confirmed diagnoses of moderate to severe COVID-19, > 18 years old, oxygen saturation ≤ 93%, PaO2/FiO2 ratio < 300, who required hospitalization and were discharged were included. We excluded those who died before the follow-up visit, declined to participate, or could not be contacted. Results The mean age was 53.79 ± 12.90 years. IMV subjects had lower phase angle and handgrip strength and higher impedance index, frequency of low muscle mass, and low muscle strength than those without IMV. The risk factors of sarcopenia were > 60 years of age, diabetes, obesity, IMV, and prolonged hospital stay. The multivariate model showed that age > 60 years (OR: 4.91, 95% CI: 2.26–10.63), obesity (OR: 3.73, 95% CI: 1.21–11.54), and interaction between prolonged length of hospital stay and IMV (OR: 2.92; 95% CI: 1.21–7.02) were related to a higher risk of sarcopenia. Conclusion Obesity and the interaction between prolonged length of hospital stay and IMV are associated with a higher risk of sarcopenia at 3 months after severe or moderate COVID-19 infection. |
| first_indexed | 2024-12-12T16:32:50Z |
| format | Article |
| id | doaj.art-119ca62b8db745278108d9210cb152c3 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-12T16:32:50Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-119ca62b8db745278108d9210cb152c32022-12-22T00:18:44ZengBMCBMC Pulmonary Medicine1471-24662022-06-012211810.1186/s12890-022-02014-xBody composition and risk factors associated with sarcopenia in post-COVID patients after moderate or severe COVID-19 infectionsDulce González-Islas0Carlos Sánchez-Moreno1Arturo Orea-Tejeda2Samantha Hernández-López3Fernanda Salgado-Fernández4Candace Keirns-Davis5Susana Galicia-Amor6Esperanza Trejo-Mellado7Laura Gochicoa-Rangel8Armando Castorena-Maldonado9Heart Failure and Respiratory Distress Clinic, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”Heart Failure and Respiratory Distress Clinic, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”Heart Failure and Respiratory Distress Clinic, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”Heart Failure and Respiratory Distress Clinic, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”Heart Failure and Respiratory Distress Clinic, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”Heart Failure and Respiratory Distress Clinic, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”Pulmonary Rehabilitation Department, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”Pulmonary Rehabilitation Department, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”Department of Pulmonary Physiology, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”Otorhinolaryngology Department, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”Abstract Background Post-COVID-19 syndrome is characterized by diverse symptoms and abnormalities that persist beyond 12 weeks from the onset of acute COVID-19. Severity disease has been associated with more musculoskeletal alterations such as muscle weakness, dyspnea, and distance walking. The aim was to evaluate the impact of invasive mechanical ventilation (IMV) on body composition and investigate risk factors associated with sarcopenia in post-COVID-19 patients three months after moderate or severe COVID-19 infections. Methods Cross-sectional study. 530 patients with PCR-confirmed diagnoses of moderate to severe COVID-19, > 18 years old, oxygen saturation ≤ 93%, PaO2/FiO2 ratio < 300, who required hospitalization and were discharged were included. We excluded those who died before the follow-up visit, declined to participate, or could not be contacted. Results The mean age was 53.79 ± 12.90 years. IMV subjects had lower phase angle and handgrip strength and higher impedance index, frequency of low muscle mass, and low muscle strength than those without IMV. The risk factors of sarcopenia were > 60 years of age, diabetes, obesity, IMV, and prolonged hospital stay. The multivariate model showed that age > 60 years (OR: 4.91, 95% CI: 2.26–10.63), obesity (OR: 3.73, 95% CI: 1.21–11.54), and interaction between prolonged length of hospital stay and IMV (OR: 2.92; 95% CI: 1.21–7.02) were related to a higher risk of sarcopenia. Conclusion Obesity and the interaction between prolonged length of hospital stay and IMV are associated with a higher risk of sarcopenia at 3 months after severe or moderate COVID-19 infection.https://doi.org/10.1186/s12890-022-02014-xPost-COVID-19SarcopeniaBody compositionInvasive mechanical ventilation |
| spellingShingle | Dulce González-Islas Carlos Sánchez-Moreno Arturo Orea-Tejeda Samantha Hernández-López Fernanda Salgado-Fernández Candace Keirns-Davis Susana Galicia-Amor Esperanza Trejo-Mellado Laura Gochicoa-Rangel Armando Castorena-Maldonado Body composition and risk factors associated with sarcopenia in post-COVID patients after moderate or severe COVID-19 infections BMC Pulmonary Medicine Post-COVID-19 Sarcopenia Body composition Invasive mechanical ventilation |
| title | Body composition and risk factors associated with sarcopenia in post-COVID patients after moderate or severe COVID-19 infections |
| title_full | Body composition and risk factors associated with sarcopenia in post-COVID patients after moderate or severe COVID-19 infections |
| title_fullStr | Body composition and risk factors associated with sarcopenia in post-COVID patients after moderate or severe COVID-19 infections |
| title_full_unstemmed | Body composition and risk factors associated with sarcopenia in post-COVID patients after moderate or severe COVID-19 infections |
| title_short | Body composition and risk factors associated with sarcopenia in post-COVID patients after moderate or severe COVID-19 infections |
| title_sort | body composition and risk factors associated with sarcopenia in post covid patients after moderate or severe covid 19 infections |
| topic | Post-COVID-19 Sarcopenia Body composition Invasive mechanical ventilation |
| url | https://doi.org/10.1186/s12890-022-02014-x |
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