Mathematical modeling of interleukin-27 induction of anti-tumor T cells response.

Interleukin-12 is a pro-inflammatory cytokine which promotes Th1 and cytotoxic T lymphocyte activities, such as Interferon-[Formula: see text] secretion. For this reason Interleukin-12 could be a powerful therapeutic agent for cancer treatment. However, Interleukin-12 is also excessively toxic. Inte...

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Bibliographic Details
Main Authors: Kang-Ling Liao, Xue-Feng Bai, Avner Friedman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3954918?pdf=render