Effect of mindfulness-based cognitive therapy vs. psychoeducational intervention on plasma brain-derived neurotrophic factor and cognitive function in bipolar patients: a randomized controlled trial
IntroductionFew controlled trials have assessed the benefits of Mindfulness Based Cognitive Therapy (MBCT) on cognitive functions and brain-derived neurotrophic factor (BDNF) in bipolar disorder (BD). This study aims to evaluate the impact of MBCT adjunctive treatment on these variables. Main hypoth...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1279342/full |
| _version_ | 1797365490712051712 |
|---|---|
| author | Diego Carracedo-Sanchidrian Diego Carracedo-Sanchidrian Consuelo de Dios-Perrino Consuelo de Dios-Perrino Consuelo de Dios-Perrino Carmen Bayon-Perez Carmen Bayon-Perez Carmen Bayon-Perez Beatriz Rodriguez-Vega Beatriz Rodriguez-Vega Beatriz Rodriguez-Vega Maria-Fe Bravo-Ortiz Maria-Fe Bravo-Ortiz Maria-Fe Bravo-Ortiz Miguel Á. Ortega Miguel Á. Ortega Ana-Maria González-Pinto Guillermo Lahera Guillermo Lahera Guillermo Lahera |
| author_facet | Diego Carracedo-Sanchidrian Diego Carracedo-Sanchidrian Consuelo de Dios-Perrino Consuelo de Dios-Perrino Consuelo de Dios-Perrino Carmen Bayon-Perez Carmen Bayon-Perez Carmen Bayon-Perez Beatriz Rodriguez-Vega Beatriz Rodriguez-Vega Beatriz Rodriguez-Vega Maria-Fe Bravo-Ortiz Maria-Fe Bravo-Ortiz Maria-Fe Bravo-Ortiz Miguel Á. Ortega Miguel Á. Ortega Ana-Maria González-Pinto Guillermo Lahera Guillermo Lahera Guillermo Lahera |
| author_sort | Diego Carracedo-Sanchidrian |
| collection | DOAJ |
| description | IntroductionFew controlled trials have assessed the benefits of Mindfulness Based Cognitive Therapy (MBCT) on cognitive functions and brain-derived neurotrophic factor (BDNF) in bipolar disorder (BD). This study aims to evaluate the impact of MBCT adjunctive treatment on these variables. Main hypothesis was that MBCT would improve cognitive functioning and BDNF more than Psychoeducation and TAU.MethodsRandomized, multicenter, prospective and single-blinded trial. Included BD outpatients randomly assigned to three treatment arms: MBCT plus treatment as usual (TAU), Psychoeducation plus Tau and TAU. Cognitive functions were assessed with Continuous Performance Test-III, Stroop Test, Trail Making Test, Digit Span and Letter-Number Sequencing from Wechsler Adult Intelligence Scale III, Face Emotion Identification Task and Face Emotion Discrimination Task. BDNF serum level was measured with ELISA. Patients were assessed at baseline, 8 weeks and 6 months.ResultsEighty-four patients were recruited (TAU = 10, Psychoeducation = 34, MBCT = 40). No significant differences between treatment groups were found. MBCT does not achieve better results than Psychoeducation or TAU.DiscussionBeing Psychoeducation and TAU efficient interventions, as well as the scarce duration of a more complex intervention, such as MBCT, are suggested as explanatory variables of these results.Trial registrationClinicalTrials.gov: NCT02133170. Registered 04/30/2014. |
| first_indexed | 2024-03-08T16:50:42Z |
| format | Article |
| id | doaj.art-11a0cb6d55f1489ba3eb9dc6a615d0ea |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-03-08T16:50:42Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-11a0cb6d55f1489ba3eb9dc6a615d0ea2024-01-05T04:42:09ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402024-01-011410.3389/fpsyt.2023.12793421279342Effect of mindfulness-based cognitive therapy vs. psychoeducational intervention on plasma brain-derived neurotrophic factor and cognitive function in bipolar patients: a randomized controlled trialDiego Carracedo-Sanchidrian0Diego Carracedo-Sanchidrian1Consuelo de Dios-Perrino2Consuelo de Dios-Perrino3Consuelo de Dios-Perrino4Carmen Bayon-Perez5Carmen Bayon-Perez6Carmen Bayon-Perez7Beatriz Rodriguez-Vega8Beatriz Rodriguez-Vega9Beatriz Rodriguez-Vega10Maria-Fe Bravo-Ortiz11Maria-Fe Bravo-Ortiz12Maria-Fe Bravo-Ortiz13Miguel Á. Ortega14Miguel Á. Ortega15Ana-Maria González-Pinto16Guillermo Lahera17Guillermo Lahera18Guillermo Lahera19Department of Psychiatry, University Hospital La Paz, Madrid, SpainLa Paz Hospital Institute for Health Research (IdiPAZ), Madrid, SpainDepartment of Psychiatry, University Hospital La Paz, Madrid, SpainLa Paz Hospital Institute for Health Research (IdiPAZ), Madrid, SpainAutonomous University of Madrid (UAM), Madrid, SpainDepartment of Psychiatry, University Hospital La Paz, Madrid, SpainLa Paz Hospital Institute for Health Research (IdiPAZ), Madrid, SpainAutonomous University of Madrid (UAM), Madrid, SpainDepartment of Psychiatry, University Hospital La Paz, Madrid, SpainLa Paz Hospital Institute for Health Research (IdiPAZ), Madrid, SpainAutonomous University of Madrid (UAM), Madrid, SpainDepartment of Psychiatry, University Hospital La Paz, Madrid, SpainLa Paz Hospital Institute for Health Research (IdiPAZ), Madrid, SpainAutonomous University of Madrid (UAM), Madrid, SpainFaculty of Medicine and Health Sciences, University of Alcalá, Madrid, SpainCIBERSAM, Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, SpainBIOARABA, UPV/EHU, CIBERSAM, Department of Psychiatry, Hospital Santiago Apostol, Vitoria, SpainFaculty of Medicine and Health Sciences, University of Alcalá, Madrid, SpainCIBERSAM, Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, SpainPrincipe de Asturias University Hospital, Alcalá, SpainIntroductionFew controlled trials have assessed the benefits of Mindfulness Based Cognitive Therapy (MBCT) on cognitive functions and brain-derived neurotrophic factor (BDNF) in bipolar disorder (BD). This study aims to evaluate the impact of MBCT adjunctive treatment on these variables. Main hypothesis was that MBCT would improve cognitive functioning and BDNF more than Psychoeducation and TAU.MethodsRandomized, multicenter, prospective and single-blinded trial. Included BD outpatients randomly assigned to three treatment arms: MBCT plus treatment as usual (TAU), Psychoeducation plus Tau and TAU. Cognitive functions were assessed with Continuous Performance Test-III, Stroop Test, Trail Making Test, Digit Span and Letter-Number Sequencing from Wechsler Adult Intelligence Scale III, Face Emotion Identification Task and Face Emotion Discrimination Task. BDNF serum level was measured with ELISA. Patients were assessed at baseline, 8 weeks and 6 months.ResultsEighty-four patients were recruited (TAU = 10, Psychoeducation = 34, MBCT = 40). No significant differences between treatment groups were found. MBCT does not achieve better results than Psychoeducation or TAU.DiscussionBeing Psychoeducation and TAU efficient interventions, as well as the scarce duration of a more complex intervention, such as MBCT, are suggested as explanatory variables of these results.Trial registrationClinicalTrials.gov: NCT02133170. Registered 04/30/2014.https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1279342/fullbipolar disordermindfulness based cognitive therapypsychoeducationBrainderived neurotrophic factorcognitioncognitive impairment |
| spellingShingle | Diego Carracedo-Sanchidrian Diego Carracedo-Sanchidrian Consuelo de Dios-Perrino Consuelo de Dios-Perrino Consuelo de Dios-Perrino Carmen Bayon-Perez Carmen Bayon-Perez Carmen Bayon-Perez Beatriz Rodriguez-Vega Beatriz Rodriguez-Vega Beatriz Rodriguez-Vega Maria-Fe Bravo-Ortiz Maria-Fe Bravo-Ortiz Maria-Fe Bravo-Ortiz Miguel Á. Ortega Miguel Á. Ortega Ana-Maria González-Pinto Guillermo Lahera Guillermo Lahera Guillermo Lahera Effect of mindfulness-based cognitive therapy vs. psychoeducational intervention on plasma brain-derived neurotrophic factor and cognitive function in bipolar patients: a randomized controlled trial Frontiers in Psychiatry bipolar disorder mindfulness based cognitive therapy psychoeducation Brainderived neurotrophic factor cognition cognitive impairment |
| title | Effect of mindfulness-based cognitive therapy vs. psychoeducational intervention on plasma brain-derived neurotrophic factor and cognitive function in bipolar patients: a randomized controlled trial |
| title_full | Effect of mindfulness-based cognitive therapy vs. psychoeducational intervention on plasma brain-derived neurotrophic factor and cognitive function in bipolar patients: a randomized controlled trial |
| title_fullStr | Effect of mindfulness-based cognitive therapy vs. psychoeducational intervention on plasma brain-derived neurotrophic factor and cognitive function in bipolar patients: a randomized controlled trial |
| title_full_unstemmed | Effect of mindfulness-based cognitive therapy vs. psychoeducational intervention on plasma brain-derived neurotrophic factor and cognitive function in bipolar patients: a randomized controlled trial |
| title_short | Effect of mindfulness-based cognitive therapy vs. psychoeducational intervention on plasma brain-derived neurotrophic factor and cognitive function in bipolar patients: a randomized controlled trial |
| title_sort | effect of mindfulness based cognitive therapy vs psychoeducational intervention on plasma brain derived neurotrophic factor and cognitive function in bipolar patients a randomized controlled trial |
| topic | bipolar disorder mindfulness based cognitive therapy psychoeducation Brainderived neurotrophic factor cognition cognitive impairment |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1279342/full |
| work_keys_str_mv | AT diegocarracedosanchidrian effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT diegocarracedosanchidrian effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT consuelodediosperrino effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT consuelodediosperrino effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT consuelodediosperrino effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT carmenbayonperez effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT carmenbayonperez effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT carmenbayonperez effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT beatrizrodriguezvega effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT beatrizrodriguezvega effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT beatrizrodriguezvega effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT mariafebravoortiz effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT mariafebravoortiz effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT mariafebravoortiz effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT miguelaortega effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT miguelaortega effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT anamariagonzalezpinto effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT guillermolahera effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT guillermolahera effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial AT guillermolahera effectofmindfulnessbasedcognitivetherapyvspsychoeducationalinterventiononplasmabrainderivedneurotrophicfactorandcognitivefunctioninbipolarpatientsarandomizedcontrolledtrial |