Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China
Atrial fibrillation (AF) is an important cardiovascular disease that causes a great burden of disease. However, there is limited evidence of a link between air pollution exposure and AF. This study aimed to explore the short-term association between air pollution and AF. We obtained daily hospitaliz...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-12-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651321010733 |
| _version_ | 1818402390556016640 |
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| author | Yan Fang Hongyi Cheng Xu Li Yifan Xu Hang Xu Zhichao Chen Weixin Cai Cong Liu Jingyan Cao |
| author_facet | Yan Fang Hongyi Cheng Xu Li Yifan Xu Hang Xu Zhichao Chen Weixin Cai Cong Liu Jingyan Cao |
| author_sort | Yan Fang |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is an important cardiovascular disease that causes a great burden of disease. However, there is limited evidence of a link between air pollution exposure and AF. This study aimed to explore the short-term association between air pollution and AF. We obtained daily hospitalization of AF in two major hospitals of Yancheng, China from May, 2015 to May, 2020. Generalized additive models with quasi-Poisson regression were used to assess the associations between six criteria air pollutants and AF hospitalization. We explored the lag patterns, and visualized the concentration-response relationships. The robustness of the association was tested by two-pollutant model, and we explored potential effect modification by age, sex and season. A total of 15,171 inpatients from two hospitals were collected in this study with an average daily count of eight patients. We observed consistent and significant associations between six air pollutants and AF on lag 0–4 days. A 10 ug/m3 increase in PM2.5 was associated with 2.81% (95%CI: 1.44%, 4.20%) changes in AF, and the effect estimate was 1.67% (95%CI: 0.77%, 2.59%) for PM10, 4.90% (95%CI: 1.69%, 8.22%) for NO2, 6.81% (95%CI: 0.46%, 13.57%) for SO2, 1.82% (95%CI: 0.60%, 3.06%) for O3; a 0.1 mg/m3 increase in CO was associated with 2.55% (95%CI: 0.91%, 4.21%) increments in AF. Associations of PM2.5 and PM10 were robust after adjusting for SO2, NO2, CO, and O3, but not vice versa. Female patients and those aged less 70 years had larger risk of AF associated with air pollution exposure. The concentration-response curves of the six pollutants were almost linear and increasing with no obvious thresholds. This time-series study in Yancheng demonstrated increased risk of AF and a delayed effect over lag 0–4 days. Our findings suggested need of prevention and protection against these environmental risk factors for AF in health departments. |
| first_indexed | 2024-12-14T08:07:36Z |
| format | Article |
| id | doaj.art-11a11b67d31e463996167c3b5db54dc1 |
| institution | Directory Open Access Journal |
| issn | 0147-6513 |
| language | English |
| last_indexed | 2024-12-14T08:07:36Z |
| publishDate | 2021-12-01 |
| publisher | Elsevier |
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| series | Ecotoxicology and Environmental Safety |
| spelling | doaj.art-11a11b67d31e463996167c3b5db54dc12022-12-21T23:10:07ZengElsevierEcotoxicology and Environmental Safety0147-65132021-12-01228112961Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, ChinaYan Fang0Hongyi Cheng1Xu Li2Yifan Xu3Hang Xu4Zhichao Chen5Weixin Cai6Cong Liu7Jingyan Cao8Department of Cardiology, the Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, China; Department of Cardiology, the First People’s Hospital of Yancheng, Yancheng 224006, ChinaDepartment of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaDepartment of Cardiology, the Yancheng School of Clinical Medicine of Nanjing Medical University and Yancheng Third People 's Hospital, Yancheng 224006, ChinaDepartment of Radiology, the Fourth Affiliated Hospital of Nantong University, Yancheng 224006, China; Department of Radiology, the First People’s Hospital of Yancheng, Yancheng 224006, ChinaDepartment of Neurology, the Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, China; Department of Neurology, the First People’s Hospital of Yancheng, Yancheng 224006, ChinaDepartment of Cardiology, the Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, China; Department of Cardiology, the First People’s Hospital of Yancheng, Yancheng 224006, ChinaDepartment of Hematology, the Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, China; Department of Hematology, the First People’s Hospital of Yancheng, Yancheng 224006, ChinaSchool of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai 200032, China; Correspondence to: No. 130 Dong-An Road, Shanghai 200032, China.Department of Cardiology, the Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, China; Department of Cardiology, the First People’s Hospital of Yancheng, Yancheng 224006, China; Correspondence to: No. 166 Yulong West Road, Yancheng 224006, China.Atrial fibrillation (AF) is an important cardiovascular disease that causes a great burden of disease. However, there is limited evidence of a link between air pollution exposure and AF. This study aimed to explore the short-term association between air pollution and AF. We obtained daily hospitalization of AF in two major hospitals of Yancheng, China from May, 2015 to May, 2020. Generalized additive models with quasi-Poisson regression were used to assess the associations between six criteria air pollutants and AF hospitalization. We explored the lag patterns, and visualized the concentration-response relationships. The robustness of the association was tested by two-pollutant model, and we explored potential effect modification by age, sex and season. A total of 15,171 inpatients from two hospitals were collected in this study with an average daily count of eight patients. We observed consistent and significant associations between six air pollutants and AF on lag 0–4 days. A 10 ug/m3 increase in PM2.5 was associated with 2.81% (95%CI: 1.44%, 4.20%) changes in AF, and the effect estimate was 1.67% (95%CI: 0.77%, 2.59%) for PM10, 4.90% (95%CI: 1.69%, 8.22%) for NO2, 6.81% (95%CI: 0.46%, 13.57%) for SO2, 1.82% (95%CI: 0.60%, 3.06%) for O3; a 0.1 mg/m3 increase in CO was associated with 2.55% (95%CI: 0.91%, 4.21%) increments in AF. Associations of PM2.5 and PM10 were robust after adjusting for SO2, NO2, CO, and O3, but not vice versa. Female patients and those aged less 70 years had larger risk of AF associated with air pollution exposure. The concentration-response curves of the six pollutants were almost linear and increasing with no obvious thresholds. This time-series study in Yancheng demonstrated increased risk of AF and a delayed effect over lag 0–4 days. Our findings suggested need of prevention and protection against these environmental risk factors for AF in health departments.http://www.sciencedirect.com/science/article/pii/S0147651321010733Air pollutionCriteria air pollutantsAtrial fibrillationTime-series study |
| spellingShingle | Yan Fang Hongyi Cheng Xu Li Yifan Xu Hang Xu Zhichao Chen Weixin Cai Cong Liu Jingyan Cao Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China Ecotoxicology and Environmental Safety Air pollution Criteria air pollutants Atrial fibrillation Time-series study |
| title | Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China |
| title_full | Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China |
| title_fullStr | Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China |
| title_full_unstemmed | Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China |
| title_short | Short-term exposure to ambient air pollution and atrial fibrillation hospitalization: A time-series study in Yancheng, China |
| title_sort | short term exposure to ambient air pollution and atrial fibrillation hospitalization a time series study in yancheng china |
| topic | Air pollution Criteria air pollutants Atrial fibrillation Time-series study |
| url | http://www.sciencedirect.com/science/article/pii/S0147651321010733 |
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