Reward sensitivity modulates the brain reward pathway in stress resilience via the inherent neuroendocrine system
In the previous 10 years, researchers have suggested a critical role for the brain reward system in stress resilience. However, no study has provided an empirical link between activity in the mesostriatal reward regions during stress and the recovery of cortisol stress response. Moreover, although r...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
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| Series: | Neurobiology of Stress |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352289522000601 |
| _version_ | 1798000563629064192 |
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| author | Weiyu Hu Xiaolin Zhao Yadong Liu Yipeng Ren Zhenni Wei Zihan Tang Yun Tian Yadong Sun Juan Yang |
| author_facet | Weiyu Hu Xiaolin Zhao Yadong Liu Yipeng Ren Zhenni Wei Zihan Tang Yun Tian Yadong Sun Juan Yang |
| author_sort | Weiyu Hu |
| collection | DOAJ |
| description | In the previous 10 years, researchers have suggested a critical role for the brain reward system in stress resilience. However, no study has provided an empirical link between activity in the mesostriatal reward regions during stress and the recovery of cortisol stress response. Moreover, although reward sensitivity as a trait has been demonstrated to promote stress resilience, it remains unclear whether it modulates the brain reward system in stress resilience and how this effect is achieved by the inherent neuroendocrine system. To investigate these uncertainties, 70 young adults were recruited to participate in a ScanSTRESS task, and their brain imaging data and saliva samples (for cortisol assay) were collected during the task. In addition, we assessed reward sensitivity, cortisol awakening response, and intrinsic functional connectivity of the brain in all the participants. We found that left putamen activation during stress exposure positively predicted cortisol recovery. In addition, reward sensitivity was positively linked with activation of the left putamen, and this relationship was serially mediated by the cortisol awakening response and right hippocampus-left inferior frontal gyrus intrinsic connectivity. These findings suggest that reward sensitivity modulates reward pathways in stress resilience through the interplay of the diurnal stress response system and network of the hippocampus-prefrontal circuitry. Summarily, the current study built a model to highlight the dynamic and multifaceted interaction between pertinent allostatic factors in the reward-resilience pathway and uncovered new insight into the resilience function of the mesostriatal reward system during stress. |
| first_indexed | 2024-04-11T11:22:18Z |
| format | Article |
| id | doaj.art-11a1bb051aec4f97ac00c33900187b1b |
| institution | Directory Open Access Journal |
| issn | 2352-2895 |
| language | English |
| last_indexed | 2024-04-11T11:22:18Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Stress |
| spelling | doaj.art-11a1bb051aec4f97ac00c33900187b1b2022-12-22T04:26:37ZengElsevierNeurobiology of Stress2352-28952022-09-0120100485Reward sensitivity modulates the brain reward pathway in stress resilience via the inherent neuroendocrine systemWeiyu Hu0Xiaolin Zhao1Yadong Liu2Yipeng Ren3Zhenni Wei4Zihan Tang5Yun Tian6Yadong Sun7Juan Yang8Faculty of Psychology, Southwest University, Chongqing, 400715, China; Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, ChinaFaculty of Psychology, Southwest University, Chongqing, 400715, China; Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, ChinaFaculty of Psychology, Southwest University, Chongqing, 400715, China; Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, ChinaFaculty of Psychology, Southwest University, Chongqing, 400715, China; Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, ChinaFaculty of Psychology, Southwest University, Chongqing, 400715, China; Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, ChinaFaculty of Psychology, Southwest University, Chongqing, 400715, China; Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, ChinaFaculty of Psychology, Southwest University, Chongqing, 400715, China; Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, ChinaFaculty of Psychology, Southwest University, Chongqing, 400715, ChinaFaculty of Psychology, Southwest University, Chongqing, 400715, China; Key Laboratory of Cognition and Personality, Southwest University, Chongqing, 400715, China; Corresponding author. Faculty of Psychology, Southwest University, No. 1 Tiansheng Road, Beibei, Chongqing, 400715, China.In the previous 10 years, researchers have suggested a critical role for the brain reward system in stress resilience. However, no study has provided an empirical link between activity in the mesostriatal reward regions during stress and the recovery of cortisol stress response. Moreover, although reward sensitivity as a trait has been demonstrated to promote stress resilience, it remains unclear whether it modulates the brain reward system in stress resilience and how this effect is achieved by the inherent neuroendocrine system. To investigate these uncertainties, 70 young adults were recruited to participate in a ScanSTRESS task, and their brain imaging data and saliva samples (for cortisol assay) were collected during the task. In addition, we assessed reward sensitivity, cortisol awakening response, and intrinsic functional connectivity of the brain in all the participants. We found that left putamen activation during stress exposure positively predicted cortisol recovery. In addition, reward sensitivity was positively linked with activation of the left putamen, and this relationship was serially mediated by the cortisol awakening response and right hippocampus-left inferior frontal gyrus intrinsic connectivity. These findings suggest that reward sensitivity modulates reward pathways in stress resilience through the interplay of the diurnal stress response system and network of the hippocampus-prefrontal circuitry. Summarily, the current study built a model to highlight the dynamic and multifaceted interaction between pertinent allostatic factors in the reward-resilience pathway and uncovered new insight into the resilience function of the mesostriatal reward system during stress.http://www.sciencedirect.com/science/article/pii/S2352289522000601Reward sensitivityStress resilienceCortisolPutamenHippocampus |
| spellingShingle | Weiyu Hu Xiaolin Zhao Yadong Liu Yipeng Ren Zhenni Wei Zihan Tang Yun Tian Yadong Sun Juan Yang Reward sensitivity modulates the brain reward pathway in stress resilience via the inherent neuroendocrine system Neurobiology of Stress Reward sensitivity Stress resilience Cortisol Putamen Hippocampus |
| title | Reward sensitivity modulates the brain reward pathway in stress resilience via the inherent neuroendocrine system |
| title_full | Reward sensitivity modulates the brain reward pathway in stress resilience via the inherent neuroendocrine system |
| title_fullStr | Reward sensitivity modulates the brain reward pathway in stress resilience via the inherent neuroendocrine system |
| title_full_unstemmed | Reward sensitivity modulates the brain reward pathway in stress resilience via the inherent neuroendocrine system |
| title_short | Reward sensitivity modulates the brain reward pathway in stress resilience via the inherent neuroendocrine system |
| title_sort | reward sensitivity modulates the brain reward pathway in stress resilience via the inherent neuroendocrine system |
| topic | Reward sensitivity Stress resilience Cortisol Putamen Hippocampus |
| url | http://www.sciencedirect.com/science/article/pii/S2352289522000601 |
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