Collagen II-primed Foxp3 Transduced T Cells Ameliorate Collagen-induced Arthritis in Rats: The Effect of Antigenic Priming on T Regulatory Cell Function

Collagen II-primed Foxp3 Transduced T Cells Ameliorate Collagen-induced Arthritis in Rats: The Effect of Antigenic Priming on T Regulatory Cell Function

Regulatory T cells (Tregs) play a major role in the prevention of autoimmune diseases. Transfer of Foxp3 gene into conventional T cells converts their phenotype to regulatory T cells. Therefore, the question arises as to whether adoptively transferred in vitro differentiated Treg cells specific for...

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Bibliographic Details
Main Authors: Mahdi Zavvar, Mohsen Abdolmaleki, Hamid Farajifard, Farshid Noorbakhsh, kayhan Azadmanesh, Mohammad Vojgani, Mohammad Hossein Nikcnam
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2018-08-01
Series:Iranian Journal of Allergy, Asthma and Immunology
Subjects:
Collagen-induced arthritis
Retroviral vectors
Rheumatoid arthritis
T regulatory cells
Online Access:https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1609

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