Sonic Hedgehog Induces Mesenchymal Stromal Cell Senescence-Associated Secretory Phenotype and Chondrocyte Apoptosis in Human Osteoarthritic Cartilage

Sonic Hedgehog Induces Mesenchymal Stromal Cell Senescence-Associated Secretory Phenotype and Chondrocyte Apoptosis in Human Osteoarthritic Cartilage

Hedgehog (HH) signaling plays a critical role in osteoarthritis (OA) pathogenesis, but the molecular mechanism remains to be elucidated. We show here that Sonic Hedgehog (SHH) gene expression is initiated in human normal cartilage stromal cells (NCSC) and increased in OA cartilage mesenchymal stroma...

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Bibliographic Details
Main Authors: Meng Feng, Wenguang Liu, Jing Ding, Yusheng Qiu, Qian Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
osteoarthritis
sonic hedgehog (SHH)
mesenchymal stromal (stem) cell (MSC)
chondrocyte
senescence associated secretory phenotype (SASP)
cartilage
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.716610/full

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