Low L3 skeletal muscle index associated with the clinicopathological characteristics and prognosis of ovarian cancer: a meta‐analysis
Abstract Sarcopenia is a syndrome characterized by progressive loss of skeletal muscle mass, strength and function, which is one of the most important clinical features of cancer malnutrition, representing a poor prognostic indicator in oncology. Sarcopenia is commonly assessed by measuring the skel...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-04-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.13175 |
| _version_ | 1797854100447035392 |
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| author | Yue Jin Xiaowei Ma Zhiyou Yang Nan Zhang |
| author_facet | Yue Jin Xiaowei Ma Zhiyou Yang Nan Zhang |
| author_sort | Yue Jin |
| collection | DOAJ |
| description | Abstract Sarcopenia is a syndrome characterized by progressive loss of skeletal muscle mass, strength and function, which is one of the most important clinical features of cancer malnutrition, representing a poor prognostic indicator in oncology. Sarcopenia is commonly assessed by measuring the skeletal muscle index (SMI) of the third lumbar spine (L3) using computed tomography (CT). The primary aim of this meta‐analysis was to study the association between low SMI and comprehensive clinicopathological characteristics as well as prognosis in patients with ovarian cancer. Data were searched in PubMed, EMBASE and Cochrane databases from inception to 10 June 2022. Studies evaluating the prognostic effect of SMI on ovarian cancer survival or chemotherapy‐related side effects were included. The risk of bias and study quality were assessed via the Newcastle–Ottawa Scale (NOS). The search strategy yielded 1286 hits in all three databases combined. Thirteen studies were included for qualitative and quantitative analysis, comprising 1814 patients. Our meta‐analysis revealed the significant association between low SMI and progression‐free survival (PFS) [P = 0.02; hazard ratio (HR): 1.40, 95% confidence interval (CI): 1.06–1.85], as well as 5‐year overall survival (OS) [P = 0.02; odds ratio (OR): 1.35, 95% CI: 1.05–1.74]. Low SMI was also obviously associated with body mass index (BMI) < 25 (P < 0.00001; OR: 5.08, 95% CI: 3.54–7.30), FIGO stage (P = 0.02; OR: 1.62, 95% CI: 1.06–2.45) and R0 cytoreduction (P = 0.04;OR: 1.34, 95% CI: 1.01–1.79). There was no correlation between low SMI and histological types, pathological grades and chemotherapy‐related toxicity. The quality of the evidence was relatively high according to NOS. Our meta‐analysis indicated that sarcopenia assessed by SMI was associated with poor clinical characteristics and adverse prognosis in patients with ovarian cancer. Consensus should be reached on standardized cut‐off values for defining sarcopenia in patients with ovarian cancer. |
| first_indexed | 2024-04-09T20:01:34Z |
| format | Article |
| id | doaj.art-11a818f9a94c4b65861ac3afeca8d7d7 |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-04-09T20:01:34Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-11a818f9a94c4b65861ac3afeca8d7d72023-04-03T02:38:50ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092023-04-0114269770510.1002/jcsm.13175Low L3 skeletal muscle index associated with the clinicopathological characteristics and prognosis of ovarian cancer: a meta‐analysisYue Jin0Xiaowei Ma1Zhiyou Yang2Nan Zhang3Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai ChinaDepartment of Laboratory Medicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai ChinaDepartment of Histoembryology, Genetics and Developmental Biology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Key Laboratory of Reproductive Medicine Shanghai Jiao Tong University School of Medicine Shanghai ChinaDepartment of Obstetrics and Gynecology, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai ChinaAbstract Sarcopenia is a syndrome characterized by progressive loss of skeletal muscle mass, strength and function, which is one of the most important clinical features of cancer malnutrition, representing a poor prognostic indicator in oncology. Sarcopenia is commonly assessed by measuring the skeletal muscle index (SMI) of the third lumbar spine (L3) using computed tomography (CT). The primary aim of this meta‐analysis was to study the association between low SMI and comprehensive clinicopathological characteristics as well as prognosis in patients with ovarian cancer. Data were searched in PubMed, EMBASE and Cochrane databases from inception to 10 June 2022. Studies evaluating the prognostic effect of SMI on ovarian cancer survival or chemotherapy‐related side effects were included. The risk of bias and study quality were assessed via the Newcastle–Ottawa Scale (NOS). The search strategy yielded 1286 hits in all three databases combined. Thirteen studies were included for qualitative and quantitative analysis, comprising 1814 patients. Our meta‐analysis revealed the significant association between low SMI and progression‐free survival (PFS) [P = 0.02; hazard ratio (HR): 1.40, 95% confidence interval (CI): 1.06–1.85], as well as 5‐year overall survival (OS) [P = 0.02; odds ratio (OR): 1.35, 95% CI: 1.05–1.74]. Low SMI was also obviously associated with body mass index (BMI) < 25 (P < 0.00001; OR: 5.08, 95% CI: 3.54–7.30), FIGO stage (P = 0.02; OR: 1.62, 95% CI: 1.06–2.45) and R0 cytoreduction (P = 0.04;OR: 1.34, 95% CI: 1.01–1.79). There was no correlation between low SMI and histological types, pathological grades and chemotherapy‐related toxicity. The quality of the evidence was relatively high according to NOS. Our meta‐analysis indicated that sarcopenia assessed by SMI was associated with poor clinical characteristics and adverse prognosis in patients with ovarian cancer. Consensus should be reached on standardized cut‐off values for defining sarcopenia in patients with ovarian cancer.https://doi.org/10.1002/jcsm.13175skeletal muscle indexovarian cancerclinical characteristicprognosismeta‐analysis |
| spellingShingle | Yue Jin Xiaowei Ma Zhiyou Yang Nan Zhang Low L3 skeletal muscle index associated with the clinicopathological characteristics and prognosis of ovarian cancer: a meta‐analysis Journal of Cachexia, Sarcopenia and Muscle skeletal muscle index ovarian cancer clinical characteristic prognosis meta‐analysis |
| title | Low L3 skeletal muscle index associated with the clinicopathological characteristics and prognosis of ovarian cancer: a meta‐analysis |
| title_full | Low L3 skeletal muscle index associated with the clinicopathological characteristics and prognosis of ovarian cancer: a meta‐analysis |
| title_fullStr | Low L3 skeletal muscle index associated with the clinicopathological characteristics and prognosis of ovarian cancer: a meta‐analysis |
| title_full_unstemmed | Low L3 skeletal muscle index associated with the clinicopathological characteristics and prognosis of ovarian cancer: a meta‐analysis |
| title_short | Low L3 skeletal muscle index associated with the clinicopathological characteristics and prognosis of ovarian cancer: a meta‐analysis |
| title_sort | low l3 skeletal muscle index associated with the clinicopathological characteristics and prognosis of ovarian cancer a meta analysis |
| topic | skeletal muscle index ovarian cancer clinical characteristic prognosis meta‐analysis |
| url | https://doi.org/10.1002/jcsm.13175 |
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