Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure
Objective To investigate the efficacy and safety of single or combined use of diltiazem and beprost on exercise endurance improvement after high altitude exposure in healthy young males. Methods A total of 200 non-Tibet health young men who have inhabited in plain areas for generations and were tran...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Army Medical University
2023-03-01
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| Series: | 陆军军医大学学报 |
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| Online Access: | http://aammt.tmmu.edu.cn/html/202208132.htm |
| _version_ | 1797854100671430656 |
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| author | LI Xiangjun WANG Xiuliang LIU Fangzhou ZHOU Liang ZHANG Lunwei |
| author_facet | LI Xiangjun WANG Xiuliang LIU Fangzhou ZHOU Liang ZHANG Lunwei |
| author_sort | LI Xiangjun |
| collection | DOAJ |
| description | Objective To investigate the efficacy and safety of single or combined use of diltiazem and beprost on exercise endurance improvement after high altitude exposure in healthy young males. Methods A total of 200 non-Tibet health young men who have inhabited in plain areas for generations and were transferred from plain to plateau (2 815 m) from July 2017 to August 2020 were recruited in the study. The participants were randomly assigned in group A (90 mg diltiazem sustained-release capsule placebo once a day and 40 μg beraprost placebo 3 times a day), B (90 mg diltiazem sustained-release capsule placebo once a day and 40 μg beraprost 3 times a day). C (90 mg diltiazem sustained-release capsules once a day and 40 μg beraprost placebo 3 times a day) and D (90 mg diltiazem sustained-release capsules once a day and 40 μg beraprost 3 times a day). After 5 days' continuous administration of drug and placebo, results of 6-minute walk distance (6MWD) test, pulse oxygen saturation (SpO2), blood pressure (BP) and pulmonary artery systolic pressure (PASP), and incidence of adverse reactions before and after intervention were collected and compared among the groups. Results There were 13 cases lost during follow-up, and finally 187 participants were included. After intervention, the results of 6MWD test were obviously improved (t=-9.048, -9.555, -12.903, 95%CI: -45.582~-28.984, -46.391~-30.262, -63.205~-46.128, P < 0.05), PASP values (t=10.219, 9.380, 11.069, 95%CI: 2.304~3.435, 2.277~3.519, 2.636~3.809, P < 0.05) were significantly decreased in group B, group C and group D, and the SpO2 values (t=-4.071, -4.655, 95%CI: -1.311~-0.444, -2.569~-1.031, P < 0.05) were greatly increased in groups C and D. In addition, the participants from the groups B, C and D obtained significantly prolonged 6MWD results (F=7.246, P < 0.05) and lower PASP value (F=10.421, P < 0.05) after the treatment when compared with those of group A. Moreover, SpO2 in group D was significantly higher than that in groups A, B and C (F=6.896, P < 0.05). There were no significant difference in BP value and incidence of adverse reactions. Conclusion Single or combined use of diltiazem and beprost can improve exercise endurance in healthy young males after high altitude exposure, with good safety.
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| first_indexed | 2024-04-09T20:01:34Z |
| format | Article |
| id | doaj.art-11aa3edceb494aa699cdf100ae0ccdd9 |
| institution | Directory Open Access Journal |
| issn | 2097-0927 |
| language | zho |
| last_indexed | 2024-04-09T20:01:34Z |
| publishDate | 2023-03-01 |
| publisher | Editorial Office of Journal of Army Medical University |
| record_format | Article |
| series | 陆军军医大学学报 |
| spelling | doaj.art-11aa3edceb494aa699cdf100ae0ccdd92023-04-03T03:35:37ZzhoEditorial Office of Journal of Army Medical University陆军军医大学学报2097-09272023-03-0145648048510.16016/j.2097-0927.202208132Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure LI Xiangjun0 WANG Xiuliang1LIU Fangzhou2ZHOU Liang3ZHANG Lunwei4Department of Cardiovascular and Respiratory Diseases, No.952 Hospital of Chinese PLA Army, Golmud, Qinghai Province, 816099, China Department of Cardiovascular and Respiratory Diseases, No.952 Hospital of Chinese PLA Army, Golmud, Qinghai Province, 816099, China Department of Cardiovascular and Respiratory Diseases, No.952 Hospital of Chinese PLA Army, Golmud, Qinghai Province, 816099, China Department of Cardiovascular and Respiratory Diseases, No.952 Hospital of Chinese PLA Army, Golmud, Qinghai Province, 816099, China Department of Cardiovascular and Respiratory Diseases, No.952 Hospital of Chinese PLA Army, Golmud, Qinghai Province, 816099, China Objective To investigate the efficacy and safety of single or combined use of diltiazem and beprost on exercise endurance improvement after high altitude exposure in healthy young males. Methods A total of 200 non-Tibet health young men who have inhabited in plain areas for generations and were transferred from plain to plateau (2 815 m) from July 2017 to August 2020 were recruited in the study. The participants were randomly assigned in group A (90 mg diltiazem sustained-release capsule placebo once a day and 40 μg beraprost placebo 3 times a day), B (90 mg diltiazem sustained-release capsule placebo once a day and 40 μg beraprost 3 times a day). C (90 mg diltiazem sustained-release capsules once a day and 40 μg beraprost placebo 3 times a day) and D (90 mg diltiazem sustained-release capsules once a day and 40 μg beraprost 3 times a day). After 5 days' continuous administration of drug and placebo, results of 6-minute walk distance (6MWD) test, pulse oxygen saturation (SpO2), blood pressure (BP) and pulmonary artery systolic pressure (PASP), and incidence of adverse reactions before and after intervention were collected and compared among the groups. Results There were 13 cases lost during follow-up, and finally 187 participants were included. After intervention, the results of 6MWD test were obviously improved (t=-9.048, -9.555, -12.903, 95%CI: -45.582~-28.984, -46.391~-30.262, -63.205~-46.128, P < 0.05), PASP values (t=10.219, 9.380, 11.069, 95%CI: 2.304~3.435, 2.277~3.519, 2.636~3.809, P < 0.05) were significantly decreased in group B, group C and group D, and the SpO2 values (t=-4.071, -4.655, 95%CI: -1.311~-0.444, -2.569~-1.031, P < 0.05) were greatly increased in groups C and D. In addition, the participants from the groups B, C and D obtained significantly prolonged 6MWD results (F=7.246, P < 0.05) and lower PASP value (F=10.421, P < 0.05) after the treatment when compared with those of group A. Moreover, SpO2 in group D was significantly higher than that in groups A, B and C (F=6.896, P < 0.05). There were no significant difference in BP value and incidence of adverse reactions. Conclusion Single or combined use of diltiazem and beprost can improve exercise endurance in healthy young males after high altitude exposure, with good safety. http://aammt.tmmu.edu.cn/html/202208132.htmdiltiazembeprostexercise enduranceimpacthigh altitude |
| spellingShingle | LI Xiangjun WANG Xiuliang LIU Fangzhou ZHOU Liang ZHANG Lunwei Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure 陆军军医大学学报 diltiazem beprost exercise endurance impact high altitude |
| title | Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure |
| title_full | Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure |
| title_fullStr | Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure |
| title_full_unstemmed | Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure |
| title_short | Impact of diltiazem/beprost on exercise endurance in healthy young males after high altitude exposure |
| title_sort | impact of diltiazem beprost on exercise endurance in healthy young males after high altitude exposure |
| topic | diltiazem beprost exercise endurance impact high altitude |
| url | http://aammt.tmmu.edu.cn/html/202208132.htm |
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